ES481119A1 - Procedimiento para preparar compuestos nitro. - Google Patents

Procedimiento para preparar compuestos nitro.

Info

Publication number
ES481119A1
ES481119A1 ES481119A ES481119A ES481119A1 ES 481119 A1 ES481119 A1 ES 481119A1 ES 481119 A ES481119 A ES 481119A ES 481119 A ES481119 A ES 481119A ES 481119 A1 ES481119 A1 ES 481119A1
Authority
ES
Spain
Prior art keywords
preparing
processes
pharmaceutical compositions
compositions containing
pyrrole compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES481119A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES481119A1 publication Critical patent/ES481119A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1. Procedimiento para preparar compuestos nitro, de fórmula: **(Fórmula)** en la que Het es un heterociclo de 5 o 6 miembros, totalmente insaturado, que contiene al menos un átomo de nitrógeno y está opcionalmente sustituído por alquilo inferior, trifluormetilo, hidroximetilo, halógeno, hidroxi, alcoxi inferior o amino, o un heterociclo de 5 miembros totalmente insaturado que contiene un átomo de oxígeno o azufre como único heteroátomo y está sustituído por un grupo R1R2N-A- en donde R1 y R2, que pueden ser iguales o diferentes, son cada uno hidrógeno, alquilo inferior, cicloalquilo C3-C6, alquenilo inferior, arilalquilo, alquilo inferior sustituído por alcoxi inferior, (alquilo inferior) amino o di (alquilo inferior) amino o R1 y R2 junto con el átomo de nitrógeno al cual están unidos forman un heterociclo de 5 o 6 miembros saturado, y A es un grupo alcanodiilo C1-6 recto o ramificado; Z es azufre, metileno u oxígeno; m es 0, 1 o 2 y n es 2 o 3,con la condición de que m + n es 3 o 4; R3 eshidrógeno, alquilo inferior, arilo, arilalquilo o heteroarilalquilo; y R4 es hidrógeno o alquilo inferior.
ES481119A 1978-05-30 1979-05-30 Procedimiento para preparar compuestos nitro. Expired ES481119A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2411778 1978-05-30
GB7832313 1978-08-04

Publications (1)

Publication Number Publication Date
ES481119A1 true ES481119A1 (es) 1980-09-01

Family

ID=26256929

Family Applications (1)

Application Number Title Priority Date Filing Date
ES481119A Expired ES481119A1 (es) 1978-05-30 1979-05-30 Procedimiento para preparar compuestos nitro.

Country Status (19)

Country Link
US (4) US4238494A (es)
EP (1) EP0005985B1 (es)
AR (1) AR225285A1 (es)
AU (1) AU521405B2 (es)
CA (1) CA1124719A (es)
DD (1) DD144056A5 (es)
DE (1) DE2965270D1 (es)
DK (1) DK224079A (es)
ES (1) ES481119A1 (es)
FI (1) FI68399C (es)
GR (1) GR68026B (es)
IE (1) IE48756B1 (es)
IL (1) IL57415A (es)
NO (1) NO151008C (es)
PH (1) PH18500A (es)
PL (1) PL115380B1 (es)
PT (1) PT69687A (es)
RO (1) RO77448A (es)
YU (1) YU127279A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL57415A (en) * 1978-05-30 1984-08-31 Smith Kline French Lab Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them
US4359466A (en) * 1979-10-24 1982-11-16 Smith Kline & French Laboratories Limited Guanidine compounds
EP0089765A3 (en) * 1982-03-17 1984-05-23 Smith Kline & French Laboratories Limited Pyridine derivatives
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
EP0134225B1 (en) * 1983-01-21 1988-08-17 ALKALOIDA VEGYéSZETI GYáR New alkyl diamine derivatives
US4624958A (en) * 1983-04-14 1986-11-25 Pfizer Inc. Antiprotozoal 1,4-di(p-amidinophenyl)imidazoles
ES2196163T3 (es) * 1995-07-31 2003-12-16 Shionogi & Co Derivados de pirrolidina con una actividad de inhibicion de la fosfolipasa a2.
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3518251A (en) * 1967-06-07 1970-06-30 Geigy Ag J R Certain aminoalkylamino substituted azacycloalkenes
GB1305550A (es) * 1969-10-29 1973-02-07
US3734924A (en) * 1970-10-14 1973-05-22 Smith Kline French Lab Carboxamidines
GB1400319A (en) * 1972-04-20 1975-07-16 Smith Kline French Lab Pharmaceutical compositions
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1496787A (en) * 1974-03-12 1978-01-05 Smith Kline French Lab Heteroalkylthioalkyl amidine derivatives
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
GB1563090A (en) * 1975-07-31 1980-03-19 Smith Kline French Lab Cyclobutene-diones
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
GB1574214A (en) * 1976-03-11 1980-09-03 Smith Kline French Lab Amidines
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
DE2645172C2 (de) * 1976-10-07 1982-02-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 4-Nitroimidazolen
DK168277A (da) * 1977-02-22 1978-08-23 Smithkline Corp Fremgangsmaade til fremstilling af 4-substituerede imidazolforbindelser
IN151188B (es) * 1978-02-13 1983-03-05 Smith Kline French Lab
IL57415A (en) * 1978-05-30 1984-08-31 Smith Kline French Lab Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IE48756B1 (en) 1985-05-15
AU4758179A (en) 1979-12-06
FI68399B (fi) 1985-05-31
PT69687A (en) 1979-06-01
US4331668A (en) 1982-05-25
FI791738A (fi) 1979-12-01
AU521405B2 (en) 1982-04-01
YU127279A (en) 1983-04-30
FI68399C (fi) 1985-09-10
US4407808A (en) 1983-10-04
DE2965270D1 (en) 1983-06-01
PH18500A (en) 1985-08-02
IL57415A0 (en) 1979-09-30
AR225285A1 (es) 1982-03-15
EP0005985A1 (en) 1979-12-12
DD144056A5 (de) 1980-09-24
GR68026B (es) 1981-10-27
CA1124719A (en) 1982-06-01
IL57415A (en) 1984-08-31
US4482563A (en) 1984-11-13
PL215971A1 (es) 1980-02-11
RO77448A (ro) 1981-11-04
IE791101L (en) 1979-11-30
EP0005985B1 (en) 1983-04-27
NO151008B (no) 1984-10-15
PL115380B1 (en) 1981-03-31
US4238494A (en) 1980-12-09
NO791764L (no) 1979-12-03
DK224079A (da) 1979-12-01
NO151008C (no) 1985-01-23

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