ES447717A1 - Un procedimiento para la preparacion de alcanosulfonatos de 5-mercaptopiridoxina. - Google Patents
Un procedimiento para la preparacion de alcanosulfonatos de 5-mercaptopiridoxina.Info
- Publication number
- ES447717A1 ES447717A1 ES447717A ES447717A ES447717A1 ES 447717 A1 ES447717 A1 ES 447717A1 ES 447717 A ES447717 A ES 447717A ES 447717 A ES447717 A ES 447717A ES 447717 A1 ES447717 A1 ES 447717A1
- Authority
- ES
- Spain
- Prior art keywords
- mercaptopyridoxine
- disulphide
- acetal
- sulphide
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
- C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un procedimiento para la preparación de alcanosulfonatos de 5-mercaptopiridoxina. Los alcano(C1-4)sulfonatos de 5-mercaptopiridoxina, especialmente el etano-1,2-disulfonato, constituye una forma superior, farmacéuticamente aceptable, del hidrocloruro y del hidrobromuro de 5-mercaptopiridoxina. Esta invención se refiere a sales de adición de ácidos alcanosulfónicos farmacéuticamente aceptables de 2-metil-3-hidroxi-4-hidroximetil-5-mercaptometilpiridina, una forma física, química y farmacéuticamente mejorada de la conocida 2-metil-3-hidroxi-4-hidroximetil-5-mercaptometilpiridina farmacológicamente activa (5-mercaptopiridoxina o 5-MP).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57605575A | 1975-05-09 | 1975-05-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES447717A1 true ES447717A1 (es) | 1978-04-01 |
Family
ID=24302783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES447717A Expired ES447717A1 (es) | 1975-05-09 | 1976-05-07 | Un procedimiento para la preparacion de alcanosulfonatos de 5-mercaptopiridoxina. |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS51138684A (es) |
| AR (1) | AR210883A1 (es) |
| AT (1) | AT348691B (es) |
| AU (1) | AU1342876A (es) |
| BE (1) | BE841593A (es) |
| BG (1) | BG25218A3 (es) |
| CA (1) | CA1088542A (es) |
| CH (1) | CH625222A5 (es) |
| CS (1) | CS189003B2 (es) |
| DD (1) | DD125482A5 (es) |
| DE (1) | DE2620325C3 (es) |
| DK (1) | DK143335C (es) |
| ES (1) | ES447717A1 (es) |
| FI (1) | FI61881C (es) |
| FR (1) | FR2310130A1 (es) |
| GB (1) | GB1490688A (es) |
| GR (1) | GR59817B (es) |
| HU (1) | HU172048B (es) |
| IE (1) | IE43030B1 (es) |
| IL (1) | IL49466A (es) |
| LU (1) | LU74892A1 (es) |
| NL (1) | NL7604285A (es) |
| NO (1) | NO144925C (es) |
| NZ (1) | NZ180691A (es) |
| PL (1) | PL100306B1 (es) |
| PT (1) | PT65061B (es) |
| RO (1) | RO68526A (es) |
| SE (1) | SE427033B (es) |
| ZA (1) | ZA762750B (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1695428C3 (de) * | 1967-06-08 | 1978-10-05 | Merck Patent Gmbh, 6100 Darmstadt | Derivate des 5-Mercaptopyridoxins und Verfahren zu deren Herstellung |
| US3852454A (en) * | 1973-06-15 | 1974-12-03 | Merck & Co Inc | Treatment of rheumatoid arthritis |
-
1976
- 1976-04-21 FI FI761084A patent/FI61881C/fi not_active IP Right Cessation
- 1976-04-21 DK DK179376A patent/DK143335C/da not_active IP Right Cessation
- 1976-04-21 SE SE7604580A patent/SE427033B/xx not_active IP Right Cessation
- 1976-04-22 NL NL7604285A patent/NL7604285A/xx not_active Application Discontinuation
- 1976-04-22 NO NO761367A patent/NO144925C/no unknown
- 1976-04-24 RO RO7685792A patent/RO68526A/ro unknown
- 1976-04-26 IL IL49466A patent/IL49466A/xx unknown
- 1976-04-26 CH CH521976A patent/CH625222A5/de not_active IP Right Cessation
- 1976-04-26 NZ NZ180691A patent/NZ180691A/xx unknown
- 1976-04-27 AR AR263046A patent/AR210883A1/es active
- 1976-04-28 AU AU13428/76A patent/AU1342876A/en not_active Expired
- 1976-04-29 GR GR50620A patent/GR59817B/el unknown
- 1976-04-30 PT PT65061A patent/PT65061B/pt unknown
- 1976-05-04 BG BG7600033100A patent/BG25218A3/xx unknown
- 1976-05-04 CA CA251,741A patent/CA1088542A/en not_active Expired
- 1976-05-04 GB GB18196/76A patent/GB1490688A/en not_active Expired
- 1976-05-05 FR FR7613351A patent/FR2310130A1/fr active Granted
- 1976-05-06 PL PL1976189342A patent/PL100306B1/pl unknown
- 1976-05-06 LU LU74892A patent/LU74892A1/xx unknown
- 1976-05-06 DD DD192709A patent/DD125482A5/xx unknown
- 1976-05-07 HU HU76ME00001974A patent/HU172048B/hu unknown
- 1976-05-07 DE DE2620325A patent/DE2620325C3/de not_active Expired
- 1976-05-07 IE IE990/76A patent/IE43030B1/en unknown
- 1976-05-07 CS CS763063A patent/CS189003B2/cs unknown
- 1976-05-07 ES ES447717A patent/ES447717A1/es not_active Expired
- 1976-05-07 ZA ZA762750A patent/ZA762750B/xx unknown
- 1976-05-07 BE BE166849A patent/BE841593A/xx unknown
- 1976-05-07 AT AT335676A patent/AT348691B/de not_active IP Right Cessation
- 1976-05-08 JP JP51051720A patent/JPS51138684A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991209 |