ES424882A1 - Un procedimiento para la preparacion de derivados de vin- blastina, leurosidina y leurocristina. - Google Patents

Un procedimiento para la preparacion de derivados de vin- blastina, leurosidina y leurocristina.

Info

Publication number
ES424882A1
ES424882A1 ES424882A ES424882A ES424882A1 ES 424882 A1 ES424882 A1 ES 424882A1 ES 424882 A ES424882 A ES 424882A ES 424882 A ES424882 A ES 424882A ES 424882 A1 ES424882 A1 ES 424882A1
Authority
ES
Spain
Prior art keywords
hydrogen
formula
acetyl
compound
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424882A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES424882A1 publication Critical patent/ES424882A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES424882A 1973-04-02 1974-04-02 Un procedimiento para la preparacion de derivados de vin- blastina, leurosidina y leurocristina. Expired ES424882A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (1)

Publication Number Publication Date
ES424882A1 true ES424882A1 (es) 1976-12-16

Family

ID=23363051

Family Applications (2)

Application Number Title Priority Date Filing Date
ES424882A Expired ES424882A1 (es) 1973-04-02 1974-04-02 Un procedimiento para la preparacion de derivados de vin- blastina, leurosidina y leurocristina.
ES446571A Expired ES446571A1 (es) 1973-04-02 1976-03-31 Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES446571A Expired ES446571A1 (es) 1973-04-02 1976-03-31 Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina.

Country Status (28)

Country Link
JP (2) JPS5919117B2 (ja)
AR (2) AR204004A1 (ja)
AT (1) AT340605B (ja)
BE (1) BE813168A (ja)
BG (3) BG21235A3 (ja)
CA (1) CA1042428A (ja)
CH (1) CH603669A5 (ja)
CS (1) CS185223B2 (ja)
CY (1) CY1044A (ja)
DD (1) DD113538A5 (ja)
DE (1) DE2415980A1 (ja)
DK (1) DK141511B (ja)
ES (2) ES424882A1 (ja)
FR (1) FR2223044B1 (ja)
GB (1) GB1463575A (ja)
HK (1) HK20180A (ja)
HU (1) HU171572B (ja)
IE (1) IE39071B1 (ja)
IL (1) IL44415A (ja)
KE (1) KE3028A (ja)
MY (1) MY8100025A (ja)
NL (1) NL181079C (ja)
PH (1) PH13623A (ja)
RO (2) RO73524B (ja)
SE (1) SE416206B (ja)
SU (4) SU731900A3 (ja)
YU (3) YU39719B (ja)
ZA (1) ZA741674B (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (ja) * 1976-09-08 1982-07-07 Lilly Co Eli
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
WO2006077424A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
SG164368A1 (en) 2005-07-18 2010-09-29 Bipar Sciences Inc Treatment of cancer
WO2008030891A2 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
CA2662517A1 (en) 2006-09-05 2008-03-13 Jerome Moore Treatment of cancer
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US7732491B2 (en) 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
AU2014253584B2 (en) * 2013-04-19 2017-02-02 Jinan University Vinca Alkaloid Derivatives, Preparation Method therefor and Application thereof
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
HK20180A (en) 1980-04-25
RO73524A (ro) 1984-10-31
ZA741674B (en) 1975-10-29
AT340605B (de) 1977-12-27
IL44415A (en) 1978-08-31
IE39071B1 (en) 1978-08-02
FR2223044B1 (ja) 1978-06-30
YU39876B (en) 1985-04-30
DE2415980A1 (de) 1974-10-10
MY8100025A (en) 1981-12-31
NL181079C (nl) 1987-06-16
DK141511B (da) 1980-04-08
HU171572B (hu) 1978-02-28
CH603669A5 (ja) 1978-08-31
ES446571A1 (es) 1977-06-16
JPS6033837B2 (ja) 1985-08-05
RO77533A (ro) 1982-02-01
FR2223044A1 (ja) 1974-10-25
KE3028A (en) 1980-03-28
NL181079B (nl) 1987-01-16
BG21235A3 (bg) 1976-03-20
AR203882A1 (es) 1975-10-31
BG22831A3 (bg) 1977-04-20
SU623522A3 (ru) 1978-09-05
YU113980A (en) 1982-05-31
YU39719B (en) 1985-04-30
BG21612A3 (bg) 1976-07-20
BE813168A (fr) 1974-10-02
IL44415A0 (en) 1974-06-30
RO73524B (ro) 1984-11-30
SU652896A3 (ru) 1979-03-15
SE416206B (sv) 1980-12-08
CS185223B2 (en) 1978-09-15
YU81774A (en) 1982-05-31
JPS59193895A (ja) 1984-11-02
GB1463575A (en) 1977-02-02
IE39071L (en) 1974-10-02
DK141511C (ja) 1980-09-29
SU731900A3 (ru) 1980-04-30
DD113538A5 (ja) 1975-06-12
SU784783A3 (ru) 1980-11-30
AR204004A1 (es) 1975-11-12
NL7404423A (ja) 1974-10-04
PH13623A (en) 1980-08-07
YU39875B (en) 1985-04-30
YU113880A (en) 1982-05-31
DE2415980C2 (ja) 1989-11-09
ATA267974A (de) 1977-04-15
CY1044A (en) 1980-08-01
CA1042428A (en) 1978-11-14
JPS49128000A (ja) 1974-12-07
AU6671974A (en) 1975-09-18
JPS5919117B2 (ja) 1984-05-02

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