ES412061A1 - Phenoxypropylamine derivatives and the preparation thereof - Google Patents
Phenoxypropylamine derivatives and the preparation thereofInfo
- Publication number
- ES412061A1 ES412061A1 ES73412061A ES412061A ES412061A1 ES 412061 A1 ES412061 A1 ES 412061A1 ES 73412061 A ES73412061 A ES 73412061A ES 412061 A ES412061 A ES 412061A ES 412061 A1 ES412061 A1 ES 412061A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- moiety
- alkyl
- signifies
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedure for obtaining phenoxypropyl amine derivatives, of general formula **(See formula)** wherein X signifies an alkylene moiety, possibly branched, R1 and R2, which may be the same or different, each signify a hydrogen atom, an alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, haloalkyl group, or aminoalkyl, a mono- or dialkylaminoalkyl group, an acylaminoalkyl or cyanoalkyl group or an aryl or aralkyl group, optionally substituted, R3 signifies an alkyl, alkenyl, alkenyloxy, alkoxy, acyl, cyano, nitro, amino or acylamino group, or a halogen atom, means an alkyl, preferably branched, residue, a hydroxyalkyl or cycloalkyl residue, and n is defined as 0 or as an integer from 1 to 3, as well as its pharmaceutically compatible acid addition salts, characterized in that a phenoxypropane derivative of general formula **(See formula)** where Y means the group (see graph), where Hal represents chlorine, bromine or iodine and R1, R2, R3, X and n have the definitions as in formula I, or a mixture of these compounds, in which Y has more than one of the indicated meanings, is reacted, at room temperature, or at a higher temperature, with ammonia or amines of general formula III H2n-R5 (III) in which R5 means hydrogen or the R4 moiety and the R5 moieties, possibly existing with the meaning of hydrogen, by reaction of the reaction product with a carbonyl compound of general formula IV **(See formula)** wherein R6 signifies a hydrogen atom or an alkyl moiety and R7 signifies an alkyl moiety, optionally substituted by hydroxy, or R6 and R7, together represent an alkylene moiety, by simultaneous reduction, or further, are transformed into the moiety R4 and the ketone groups, if any existing on the propoxy side chain, are simultaneously or subsequently reduced to the hydroxyl group and the bases obtained as reaction products are isolated as such or in the form of salts, or from The salts obtained are liberated from the bases and, if desired, transformed into pharmaceutically compatible salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT157372A AT321315B (en) | 1972-02-28 | 1972-02-28 | Process for the preparation of new ureidophenoxypropylamine derivatives and their salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES412061A1 true ES412061A1 (en) | 1976-01-01 |
Family
ID=3516334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES73412061A Expired ES412061A1 (en) | 1972-02-28 | 1973-02-26 | Phenoxypropylamine derivatives and the preparation thereof |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5626654B2 (en) |
| AT (1) | AT321315B (en) |
| BE (1) | BE796029A (en) |
| CH (1) | CH577956A5 (en) |
| CS (1) | CS168625B2 (en) |
| DD (1) | DD105214A1 (en) |
| DE (1) | DE2264182C3 (en) |
| DK (1) | DK136185B (en) |
| ES (1) | ES412061A1 (en) |
| FI (1) | FI59582C (en) |
| FR (1) | FR2173990B1 (en) |
| GB (1) | GB1397663A (en) |
| HU (1) | HU165235B (en) |
| IE (1) | IE37271B1 (en) |
| LU (1) | LU66869A1 (en) |
| NL (1) | NL7300688A (en) |
| PL (1) | PL82613B1 (en) |
| RO (1) | RO62862A (en) |
| SU (1) | SU530639A3 (en) |
| YU (1) | YU36158B (en) |
| ZA (1) | ZA73949B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1149819A (en) * | 1970-01-08 | 1983-07-12 | Max Wilhelm | Process for the manufacture of new amines |
-
1972
- 1972-02-28 AT AT157372A patent/AT321315B/en not_active IP Right Cessation
- 1972-12-29 PL PL1972159973A patent/PL82613B1/pl unknown
- 1972-12-29 DE DE2264182A patent/DE2264182C3/en not_active Expired
-
1973
- 1973-01-10 FI FI60/73A patent/FI59582C/en active
- 1973-01-17 CS CS388A patent/CS168625B2/cs unknown
- 1973-01-17 RO RO7300073527A patent/RO62862A/en unknown
- 1973-01-17 NL NL7300688A patent/NL7300688A/xx not_active Application Discontinuation
- 1973-01-19 LU LU66869A patent/LU66869A1/xx unknown
- 1973-02-02 YU YU260/73A patent/YU36158B/en unknown
- 1973-02-05 SU SU1879539A patent/SU530639A3/en active
- 1973-02-05 FR FR7303913A patent/FR2173990B1/fr not_active Expired
- 1973-02-05 GB GB568173A patent/GB1397663A/en not_active Expired
- 1973-02-06 DK DK60373AA patent/DK136185B/en unknown
- 1973-02-08 IE IE198/73A patent/IE37271B1/en unknown
- 1973-02-09 ZA ZA730949A patent/ZA73949B/en unknown
- 1973-02-13 HU HUOE189A patent/HU165235B/hu unknown
- 1973-02-26 DD DD169049A patent/DD105214A1/xx unknown
- 1973-02-26 JP JP2229773A patent/JPS5626654B2/ja not_active Expired
- 1973-02-26 CH CH275373A patent/CH577956A5/xx not_active IP Right Cessation
- 1973-02-26 ES ES73412061A patent/ES412061A1/en not_active Expired
- 1973-02-27 BE BE128160A patent/BE796029A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5205273A (en) | 1974-08-15 |
| DD105214A1 (en) | 1974-04-12 |
| FI59582B (en) | 1981-05-29 |
| FI59582C (en) | 1981-09-10 |
| LU66869A1 (en) | 1973-03-19 |
| JPS5626654B2 (en) | 1981-06-19 |
| CS168625B2 (en) | 1976-06-29 |
| DK136185C (en) | 1978-02-13 |
| DE2264182A1 (en) | 1973-12-20 |
| IE37271B1 (en) | 1977-06-08 |
| NL7300688A (en) | 1973-08-30 |
| ZA73949B (en) | 1973-11-28 |
| AT321315B (en) | 1975-03-25 |
| YU26073A (en) | 1981-06-30 |
| DE2264182B2 (en) | 1981-06-25 |
| DE2264182C3 (en) | 1982-03-18 |
| JPS4897838A (en) | 1973-12-13 |
| YU36158B (en) | 1982-02-25 |
| HU165235B (en) | 1974-07-27 |
| PL82613B1 (en) | 1975-10-31 |
| CH577956A5 (en) | 1976-07-30 |
| SU530639A3 (en) | 1976-09-30 |
| FR2173990B1 (en) | 1976-09-03 |
| IE37271L (en) | 1973-08-28 |
| RO62862A (en) | 1978-02-15 |
| BE796029A (en) | 1973-08-27 |
| DK136185B (en) | 1977-08-29 |
| FR2173990A1 (en) | 1973-10-12 |
| GB1397663A (en) | 1975-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19840409 |