ES442895A1 - Production of phenoxy propylamine derivatives and salt - Google Patents

Production of phenoxy propylamine derivatives and salt

Info

Publication number
ES442895A1
ES442895A1 ES442895A ES442895A ES442895A1 ES 442895 A1 ES442895 A1 ES 442895A1 ES 442895 A ES442895 A ES 442895A ES 442895 A ES442895 A ES 442895A ES 442895 A1 ES442895 A1 ES 442895A1
Authority
ES
Spain
Prior art keywords
formula
moiety
alkyl
aralkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES442895A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Patheon Austria GmbH and Co KG
Original Assignee
Chemie Linz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz AG filed Critical Chemie Linz AG
Publication of ES442895A1 publication Critical patent/ES442895A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for obtaining phenoxypropyl amine derivatives of general formula, **(See formula)** where R is hydrogen or an alkyl moiety and R1 is an alkyl, cycloalkyl, aralkyl, or aryl moiety, or R and R1 together are a bivalent hydrocarbon moiety, optionally branched with 4-7 carbon atoms in the main chain, and may one or two of these carbon atoms are substituted by oxygen, sulfur or nitrogen, R2 is defined as hydrogen, an alkyl, aralkyl or aryl residue, R3 as a preferably branched alkyl residue, a hydroxyalkyl, cycloalkyl or cyanoalkyl residue and X has the definition of an oxygen atom or means the group -NOR4, where in the case that X means oxygen R2 does not have the meaning of hydrogen, a lower alkyl moiety or an aralkyl moiety, as well as its salts, characterized in that derivatives of the formula area general II, **(See formula)** where R2, R3 and X have the meaning defined in formula I, they are reacted with amines of formula III **(See formula)** where R and R1 have the above meaning, at higher temperature, and the reaction products are isolated as free bases or salts. (Machine-translation by Google Translate, not legally binding)
ES442895A 1974-11-25 1975-11-24 Production of phenoxy propylamine derivatives and salt Expired ES442895A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT943674A AT335467B (en) 1974-11-25 1974-11-25 A PROCESS FOR THE PREPARATION OF NEW 3- (P-UREIDOPHENOXY) -2-HYDROXY-AMINOPROPANES AND THEIR ACID ADDITION SALTS

Publications (1)

Publication Number Publication Date
ES442895A1 true ES442895A1 (en) 1977-04-16

Family

ID=3614119

Family Applications (1)

Application Number Title Priority Date Filing Date
ES442895A Expired ES442895A1 (en) 1974-11-25 1975-11-24 Production of phenoxy propylamine derivatives and salt

Country Status (11)

Country Link
JP (1) JPS5231046A (en)
AT (1) AT335467B (en)
CA (1) CA1044236A (en)
CH (1) CH615906A5 (en)
CS (1) CS181692B2 (en)
DD (1) DD122081A1 (en)
ES (1) ES442895A1 (en)
LU (1) LU73858A1 (en)
PL (1) PL96061B1 (en)
RO (1) RO72484A (en)
YU (1) YU39538B (en)

Also Published As

Publication number Publication date
JPS5312508B2 (en) 1978-05-01
LU73858A1 (en) 1976-09-06
ATA943674A (en) 1976-07-15
YU258175A (en) 1982-05-31
PL96061B1 (en) 1977-12-31
CH615906A5 (en) 1980-02-29
DD122081A1 (en) 1976-09-12
JPS5231046A (en) 1977-03-09
CS181692B2 (en) 1978-03-31
YU39538B (en) 1984-12-31
RO72484A (en) 1981-11-24
CA1044236A (en) 1978-12-12
AT335467B (en) 1977-03-10

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