ES442867A1 - Production of phenoxy propylamine and salt - Google Patents
Production of phenoxy propylamine and saltInfo
- Publication number
- ES442867A1 ES442867A1 ES442867A ES442867A ES442867A1 ES 442867 A1 ES442867 A1 ES 442867A1 ES 442867 A ES442867 A ES 442867A ES 442867 A ES442867 A ES 442867A ES 442867 A1 ES442867 A1 ES 442867A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- general formula
- moiety
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Procedure for obtaining phenoxypropylamine derivatives of general formula **(See formula)** where R is hydrogen or an alkyl moiety and R7 is hydrogen, an alkyl, cycloalkyl, aralkyl, or aryl moiety, or R and R1 together are a bivalent hydrocarbon moiety, optionally branched with 4-7 carbon atoms in the main chain, where one or two of these carbon atoms may be substituted by oxygen, sulfur or nitrogen, R2 is defined as a hydrogen atom, an alkyl, aralkyl or aryl residue, R3 as a preferably branched alkyl residue, a hydroxyalkyl, cycloalkyl or cyanoalkyl and R4 as a hydrogen atom, a lower alkyl moiety or aralkyl moiety, as well as their dales, characterized in that p-aminophenol derivatives of general formula **(See formula)** where R2 and R4 have the meaning defined in formula I, R5 means hydrogen or the group (see formula) and X means the group (see formula), where Hal is defined as chlorine, bromine or iodine and R and R1 have the definition above, or mixtures of compounds of formula II, where X has both definitions indicated, are reacted with compounds of general formula H2N - R3 where R3 has the meaning defined in formula I, at room temperature or higher temperature, in the compounds obtained from the general formula **(See formula)** where R2, R3 and R4 have the meaning defined above, if necessary, it is introduced, either by means of a carbamidic acid halide of general formula **(See formula)** where R and R1 have the meaning indicated above and Hal means halogen, or by means of an isocyanate of the general formula O = C = N -R1 where R1 has the meaning defined above, the ureido group and the obtained bases, of formula I, are transformed into their pharmaceutically compatible acid addition salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT939174A AT335466B (en) | 1974-11-22 | 1974-11-22 | PROCESS FOR THE PREPARATION OF NEW 3- (P-UREIDOPHENOXY) -2-HYDROXY-AMINOPROPANES AND THEIR ACID ADDITION SALTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES442867A1 true ES442867A1 (en) | 1977-04-01 |
Family
ID=3613746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES442867A Expired ES442867A1 (en) | 1974-11-22 | 1975-11-21 | Production of phenoxy propylamine and salt |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS51125249A (en) |
| AT (1) | AT335466B (en) |
| CA (1) | CA1060450A (en) |
| CH (1) | CH616657A5 (en) |
| CS (1) | CS181690B2 (en) |
| DD (1) | DD123522A1 (en) |
| ES (1) | ES442867A1 (en) |
| LU (1) | LU73840A1 (en) |
| PL (1) | PL96542B1 (en) |
| RO (1) | RO73530B (en) |
| SU (1) | SU612621A3 (en) |
-
1974
- 1974-11-22 AT AT939174A patent/AT335466B/en not_active IP Right Cessation
-
1975
- 1975-10-09 CS CS7500006845A patent/CS181690B2/en unknown
- 1975-10-14 CH CH1331375A patent/CH616657A5/en not_active IP Right Cessation
- 1975-11-12 CA CA239,424A patent/CA1060450A/en not_active Expired
- 1975-11-12 RO RO83897A patent/RO73530B/en unknown
- 1975-11-18 SU SU752189804A patent/SU612621A3/en active
- 1975-11-20 PL PL1975184866A patent/PL96542B1/en unknown
- 1975-11-20 DD DD189592A patent/DD123522A1/xx unknown
- 1975-11-20 LU LU73840A patent/LU73840A1/xx unknown
- 1975-11-21 ES ES442867A patent/ES442867A1/en not_active Expired
- 1975-11-21 JP JP50139370A patent/JPS51125249A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SU612621A3 (en) | 1978-06-25 |
| RO73530A (en) | 1984-06-21 |
| CH616657A5 (en) | 1980-04-15 |
| CA1060450A (en) | 1979-08-14 |
| RO73530B (en) | 1984-08-30 |
| AT335466B (en) | 1977-03-10 |
| PL96542B1 (en) | 1977-12-31 |
| JPS51125249A (en) | 1976-11-01 |
| LU73840A1 (en) | 1976-09-06 |
| DD123522A1 (en) | 1977-01-05 |
| JPS549196B2 (en) | 1979-04-21 |
| ATA939174A (en) | 1976-07-15 |
| CS181690B2 (en) | 1978-03-31 |
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