ES385627A2 - Procedure for the preparation of morpholine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of morpholine derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES385627A2
ES385627A2 ES385627A ES385627A ES385627A2 ES 385627 A2 ES385627 A2 ES 385627A2 ES 385627 A ES385627 A ES 385627A ES 385627 A ES385627 A ES 385627A ES 385627 A2 ES385627 A2 ES 385627A2
Authority
ES
Spain
Prior art keywords
hydrogen
formula
morpholine derivatives
alkyl
signifies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES385627A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES385627A2 publication Critical patent/ES385627A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

Abstract

Improvements introduced in the object of the main patent nº 348.087, granted on October 17, 1968, by: PROCEDURE FOR THE PREPARATION OF MORPHOLINE DERIVATIVES, of the formula **(See formula)** in which R1 signifies hydrogen and the radicals alkyl, alkenyl and cycloalkyl, R2, R3 and R4 which may be the same or different, mean both hydrogen and alkyl radicals, provided that R2, R3 and R4 do not all signify hydrogen, and when R2 and R3 are joined together with the two adjacent carbon atoms, to form a cycloalkyl ring and R4 signifies both hydrogen and an alkyl radical and X signifies an aryl radical that can be substituted, and the acid addition salts thereof, characterized by comprising the reduction of a compound of the formula **(See formula)** in which R1, R2, R3, R4 and X have the expressed meanings, with a complex metal hydride, as well as for the manufacture of those morpholine derivatives where R1 represents hydrogen, the elimination of the radial both alpha-arylalkyl and alkyl of a compound of the formula: **(See formula)** in which R2, R3, R4 and X have the aforementioned meanings and where R5 is an alpha-arylalkyl and removable alkyl radical, after which to obtain the acid addition salt, the morpholine derivatives are reacted with an acid in the form of a free base. (Machine-translation by Google Translate, not legally binding)
ES385627A 1969-11-17 1970-11-17 Procedure for the preparation of morpholine derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES385627A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5608669 1969-11-17

Publications (1)

Publication Number Publication Date
ES385627A2 true ES385627A2 (en) 1973-05-01

Family

ID=10475688

Family Applications (1)

Application Number Title Priority Date Filing Date
ES385627A Expired ES385627A2 (en) 1969-11-17 1970-11-17 Procedure for the preparation of morpholine derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
AT (1) AT302341B (en)
BE (1) BE759013R (en)
CA (1) CA927831A (en)
DE (1) DE2056589A1 (en)
ES (1) ES385627A2 (en)
FR (1) FR2073375B2 (en)
GB (1) GB1295447A (en)
IE (1) IE34714B1 (en)
NL (1) NL7016833A (en)
SU (2) SU422159A3 (en)
ZA (1) ZA707662B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2346340A2 (en) * 1975-01-29 1977-10-28 Yamanouchi Pharma Co Ltd Antidepressant (2)-indenyloxymethyl-morpholine derivs. - prepd. e.g. by acid-catalysed isomerisation of (4)-indenyloxy isomers
DE2530860A1 (en) * 1975-07-10 1977-01-20 Yoshitomi Pharmaceutical Morpholine derivs. prepn. - by reduction of corresponding halogen deriv. with metal hydride complexes
IL56369A (en) * 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
GB8824672D0 (en) * 1988-10-21 1988-11-30 Ici Plc Process
GB0219687D0 (en) 2002-08-23 2002-10-02 Lilly Co Eli Benzyl morpholine derivatives
EP1546123B1 (en) 2002-08-23 2006-05-31 Eli Lilly And Company Benzyl morpholine derivatives
WO2004017977A2 (en) * 2002-08-23 2004-03-04 Eli Lilly And Company 2- (phenoxymethyl)- and 2- (phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors
GEP20084550B (en) 2004-04-30 2008-11-25 Warner Lambert Co Substituted morpholine compounds for the treatment of central nervous system disorders
FR2880887B1 (en) * 2005-01-14 2009-01-30 Merck Sante Soc Par Actions Si HYDROXYPHENOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND THERAPEUTIC APPLICATIONS
DK2076508T3 (en) 2006-10-18 2011-02-21 Pfizer Prod Inc The biaryl ether urea compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138405A (en) * 1966-12-28 1969-01-01 Ici Ltd Morpholine derivatives

Also Published As

Publication number Publication date
FR2073375B2 (en) 1974-10-11
SU422159A3 (en) 1974-03-30
DE2056589A1 (en) 1971-05-27
IE34714L (en) 1971-05-17
FR2073375A2 (en) 1971-10-01
GB1295447A (en) 1972-11-08
BE759013R (en) 1971-05-17
NL7016833A (en) 1971-05-19
CA927831A (en) 1973-06-05
AT302341B (en) 1972-10-10
SU373945A3 (en) 1973-03-12
IE34714B1 (en) 1975-07-23
ZA707662B (en) 1971-08-25

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