ES442762A1 - N-benzylpiperazines - Google Patents
N-benzylpiperazinesInfo
- Publication number
- ES442762A1 ES442762A1 ES442762A ES442762A ES442762A1 ES 442762 A1 ES442762 A1 ES 442762A1 ES 442762 A ES442762 A ES 442762A ES 442762 A ES442762 A ES 442762A ES 442762 A1 ES442762 A1 ES 442762A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- hydrogen atom
- morpholino
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure to obtain new N-benzylpiperazine derivatives of the general formula **(See formula)** wherein R1 and R2 are the same or different and each represents a hydrogen atom or an acyl group; R3 represents a hydrogen atom, a carbamoyl group, an acyl group that is unsubstituted or substituted by mercapto or morpholino, or an alcohol group that is unsubstituted or substituted by hydroxyl, aryl or aminocarbonyl represented by the formula (see formula) in which R4 and R5 are each a hydrogen atom, a lower alcohol group having 1 to 3 carbon atoms or a cyclohexyl group, or R4 and R5 form a morpholino or piperidino ring together with the nitrogen atom adjacent thereto, and X represents a halogen atom, comprising reacting a compound of the general formula **(See formula)** wherein R1, R2 and R3 have the same meanings as defined above, with a halogenating agent. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP49133281A JPS6028826B2 (en) | 1974-11-19 | 1974-11-19 | Method for producing benzylamine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES442762A1 true ES442762A1 (en) | 1977-04-16 |
Family
ID=15100960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES442762A Expired ES442762A1 (en) | 1974-11-19 | 1975-11-18 | N-benzylpiperazines |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS6028826B2 (en) |
BE (1) | BE835689A (en) |
CA (1) | CA1074311A (en) |
DE (1) | DE2551355A1 (en) |
ES (1) | ES442762A1 (en) |
FR (1) | FR2291757A1 (en) |
GB (1) | GB1477088A (en) |
NL (1) | NL7513425A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4618677A (en) * | 1984-05-31 | 1986-10-21 | Boehringer Ingelheim Limited | Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl-thiols and -thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders |
US4722926A (en) * | 1984-11-05 | 1988-02-02 | Boehringer Ingelheim Limited | Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl thiols and thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders |
EP0968200A1 (en) | 1997-02-24 | 2000-01-05 | ZymoGenetics, Inc. | Calcitonin mimetics |
US6268367B1 (en) * | 1998-02-23 | 2001-07-31 | Zymogenetics, Inc. | Piperazine derivatives for treating bone deficit conditions |
-
1974
- 1974-11-19 JP JP49133281A patent/JPS6028826B2/en not_active Expired
-
1975
- 1975-11-15 DE DE19752551355 patent/DE2551355A1/en active Pending
- 1975-11-17 GB GB4724075A patent/GB1477088A/en not_active Expired
- 1975-11-17 NL NL7513425A patent/NL7513425A/en not_active Application Discontinuation
- 1975-11-18 BE BE161968A patent/BE835689A/en unknown
- 1975-11-18 ES ES442762A patent/ES442762A1/en not_active Expired
- 1975-11-18 FR FR7535204A patent/FR2291757A1/en active Granted
- 1975-11-18 CA CA239,892A patent/CA1074311A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE835689A (en) | 1976-05-18 |
FR2291757A1 (en) | 1976-06-18 |
FR2291757B1 (en) | 1979-09-21 |
NL7513425A (en) | 1976-05-21 |
CA1074311A (en) | 1980-03-25 |
JPS5159884A (en) | 1976-05-25 |
JPS6028826B2 (en) | 1985-07-06 |
DE2551355A1 (en) | 1976-05-20 |
GB1477088A (en) | 1977-06-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES442845A2 (en) | Novel derivatives of N-(3,4,5-trimethoxy cinnamoyl)piperazine and the process for preparing them | |
ES385627A2 (en) | Procedure for the preparation of morpholine derivatives. (Machine-translation by Google Translate, not legally binding) | |
ES442762A1 (en) | N-benzylpiperazines | |
ES409104A1 (en) | 7-(imidazolinyl-(2)-amino)-indazoles | |
ES395380A1 (en) | N-phenylthiocarbamoylthio-hydroximate pesticides | |
ES384182A1 (en) | 1-(m-halo-p-amino-phenyl)-4-aminotert.butanols-(1)and salts thereof | |
ES443421A1 (en) | 11-deoxy-15-substituted-16,17,18,19,20-pentanorprostaglandins | |
ES391180A1 (en) | Anthraquinone compounds | |
ES435351A1 (en) | 1-(3-phenylpropyl)-4-furoylpiperazine derivatives | |
ES404315A1 (en) | Nitrosourea derivatives | |
ES318461A1 (en) | Procedure for the production of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) | |
ES390057A1 (en) | A procedure for the preparation of a 1,4-benzodiazepin-2-ona. (Machine-translation by Google Translate, not legally binding) | |
ES387840A1 (en) | 2-(2-imidazolin-2-ylthio)-acetanilides | |
ES453121A1 (en) | Substituted aminoalkylaminopyridine compounds | |
ES382246A1 (en) | Procedure for the preparation of furiltiazoles. (Machine-translation by Google Translate, not legally binding) | |
ES396489A1 (en) | Benzodiazepine derivatives | |
ES442988A1 (en) | Preparation of salicylamide derivatives | |
ES437041A1 (en) | A procedure for preparing 1-ftalazone derivatives. (Machine-translation by Google Translate, not legally binding) | |
ES409555A1 (en) | A procedure for the obtaining of new derivatives of cefalosporine. (Machine-translation by Google Translate, not legally binding) | |
ES433593A1 (en) | Antibacterial cyanoquinoxaline 1,4-dioxides | |
ES369204A1 (en) | A procedure to produce a pirazol derivative. (Machine-translation by Google Translate, not legally binding) | |
ES423560A1 (en) | Peroxydicarbonates | |
ES420004A1 (en) | Nitrosourea derivatives | |
ES292847A1 (en) | A procedure for manufacturing pyridine sulfonamids (Machine-translation by Google Translate, not legally binding) | |
ES444998A1 (en) | Procedure for preparing piperazine derivatives. (Machine-translation by Google Translate, not legally binding) |