ES329218A1 - A procedure for the preparation of tetrahydro-isoquinoline derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of tetrahydro-isoquinoline derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES329218A1
ES329218A1 ES0329218A ES329218A ES329218A1 ES 329218 A1 ES329218 A1 ES 329218A1 ES 0329218 A ES0329218 A ES 0329218A ES 329218 A ES329218 A ES 329218A ES 329218 A1 ES329218 A1 ES 329218A1
Authority
ES
Spain
Prior art keywords
group
formula
tetrahydro
translation
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0329218A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES329218A1 publication Critical patent/ES329218A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A process for the preparation of tetrahydro-isoquinoline derivatives of the general formula ** (See formula) ** wherein R represents hydrogen or a lower alkyl group, R1 and R2 each represent a lower alkyl group or, together, the methylene group, R3 and R4 each represent a lower alkyl group or, together, a trimethylenic, tetramethylene or butadiene- (1,3) -ylenic- (1,4) and A represents the carbonyl group or the hydroxymethylene group, and their acid addition salts, characterized in that it consists in reacting an amine of the formula ** (See formula) ** wherein R, R1 and R2 have the meaning set forth above, or a salt of acid addition, with formaldehyde and a ketone of the formula ** (See formula) ** wherein R3 and R4 have the meaning set forth above, by means of a MANNICH reaction and, if desired, in reducing the carbonyl group of the product resulting from the reaction, in a known manner, to hydroxymethylene group and, if desired, converting the product of the reaction or reduction into the free base or in an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES0329218A 1965-07-19 1966-07-16 A procedure for the preparation of tetrahydro-isoquinoline derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES329218A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB30549/65A GB1079520A (en) 1965-07-19 1965-07-19 Novel tetrahydro-isoquinoline derivatives and a process for the manufacture thereof

Publications (1)

Publication Number Publication Date
ES329218A1 true ES329218A1 (en) 1967-08-16

Family

ID=10309382

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0329218A Expired ES329218A1 (en) 1965-07-19 1966-07-16 A procedure for the preparation of tetrahydro-isoquinoline derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
US (1) US3450704A (en)
BE (1) BE684185A (en)
BR (1) BR6681255D0 (en)
CH (1) CH464922A (en)
DE (1) DE1695147A1 (en)
DK (1) DK117704B (en)
ES (1) ES329218A1 (en)
FR (1) FR5796M (en)
GB (1) GB1079520A (en)
IL (1) IL26040A (en)
NL (1) NL6610093A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903091A (en) * 1970-02-06 1975-09-02 Sumitomo Chemical Co 1,2,3,4-Tetrahydroisoquinoline derivatives
EP2865381A1 (en) * 2006-05-18 2015-04-29 Pharmacyclics, Inc. ITK inhibitors for treating blood cell malignancies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT190517B (en) * 1954-06-22 1957-07-10 Wander Ag Dr A Process for the preparation of new, substituted tetrahydroisoquinoline compounds
GB1032054A (en) * 1963-07-19 1966-06-08 Roche Products Ltd Substituted isoquinoline and piperazine derivatives and a process for the manufacture thereof

Also Published As

Publication number Publication date
BE684185A (en) 1967-01-16
BR6681255D0 (en) 1973-12-26
DK117704B (en) 1970-05-25
FR5796M (en) 1968-02-12
GB1079520A (en) 1967-08-16
US3450704A (en) 1969-06-17
NL6610093A (en) 1967-01-20
CH464922A (en) 1968-11-15
DE1695147A1 (en) 1970-12-17
IL26040A (en) 1970-04-20

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