ES376788A1 - Procedure for the preparation of alcanolamine derivation. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of alcanolamine derivation. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES376788A1
ES376788A1 ES376788A ES376788A ES376788A1 ES 376788 A1 ES376788 A1 ES 376788A1 ES 376788 A ES376788 A ES 376788A ES 376788 A ES376788 A ES 376788A ES 376788 A1 ES376788 A1 ES 376788A1
Authority
ES
Spain
Prior art keywords
radical
formula
chosen
compound
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES376788A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB47048/69A external-priority patent/GB1285038A/en
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES376788A1 publication Critical patent/ES376788A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/30—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C243/32—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedure for the preparation of alkanolamine derivatives, of general formula: **(See formula)** wherein R1 represents a radical chosen from the group consisting of the alkyl and hydroxyalkyl radicals; A represents an alkylene radical and R2 represents a radical chosen from acyl, carbamoyl, alkylcarbamoyl, alkenylcarbamoyl and carbazoyl, or A is an alkenylene radical and R2 is chosen from acyl, cyano, alkoxycarbonyl, carbamoyl, alkylcarbamoyl, alkenylcarbamoyl and carbazoyl radicals; n represents an integer between 1 and 2; and R3, whose values can be both the same and different when n represents 2, is chosen from the group consisting of hydrogen and halogen atoms and the radicals alkyl, cycloalkyl, alkenyl, nitro, hydroxy, alkylthio, alkoxy, alkenyloxy, aryl, aryloxy, aralkyl, aralkoxy, hydroxyalkyl, alkoxyalkyl, halogenoalkyl, acyl, alkoxycarbonyl and cyano; and the esters thereof; and the aldehyde condensation products thereof, and the acid addition salts thereof, characterized in that it comprises: (a) the reaction of a member chosen from compounds of the formula: **(See formula)** in which X represents a member chosen from the group (see formula) and the group -CHOH.CH2Y, where Y represents a halogen atom, and mixtures of such compounds in which X has both meanings just manifested, with an amine of the formula NH2R1; like (b) the reaction of a member chosen from compounds of the formula: **(See formula)** and an alkali metal derivative thereof, with a compound chosen from among the formulas: (see formula) and (see formula) as well as (c) the reaction, in the presence of a base, of a compound of formula: **(See formula)** with a compound chosen from among the formulas: R2.CH2.R5 and R2.CH2-PO (OR6) 2 wherein R5 represents a member chosen from hydrogen and the carboxy radical, and R6 represents an alkyl radical of up to 6 carbon atoms, with A in the reaction product being the vinylene radical; like (d) the hydrogenolysis of a member chosen from compounds of the formula: **(See formula)** wherein R7 represents a hydrogenolizable radical, and acid addition salts thereof; like (e) the reaction under reducing conditions of a member chosen from compounds of the formula: **(See formula)** and the acid addition salts thereof, with a carbonyl compound of the formula R8.COR9, wherein R8 represents an alkyl radical and R9 represents a radical chosen from alkyl and hydroxyalkyl such that the radical R8 R9CH- has the meaning expressed for R1; after which, if desired; (f) a compound in which R2 represents a functional derivative of the carboxy radical is converted to a different compound in which R2 represents a functional derivative different from the carboxy radical; like (g) a compound in which A represents an alkenylene radical is reduced to the corresponding compound in which A represents an alkylene radical; Like (h) an alkanolamine derivative is converted to an ester thereof by reaction of an acid addition salt of the alkanolamine derivative with an acylating agent; Like (i) an alkanolamine derivative is converted to the corresponding oxazolidine derivative by reaction with an aldehyde; and after which if the alkanolamine derivative as well as its ester and its aldehyde condensation product in free base form is desired, it is converted into an acid addition salt thereof by interaction with an acid by conventional means. (Machine-translation by Google Translate, not legally binding)
ES376788A 1969-02-21 1970-02-21 Procedure for the preparation of alcanolamine derivation. (Machine-translation by Google Translate, not legally binding) Expired ES376788A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB47048/69A GB1285038A (en) 1969-02-21 1969-02-21 Alkanolamine derivatives
GB944569 1969-02-21

Publications (1)

Publication Number Publication Date
ES376788A1 true ES376788A1 (en) 1972-09-16

Family

ID=26242944

Family Applications (1)

Application Number Title Priority Date Filing Date
ES376788A Expired ES376788A1 (en) 1969-02-21 1970-02-21 Procedure for the preparation of alcanolamine derivation. (Machine-translation by Google Translate, not legally binding)

Country Status (20)

Country Link
JP (2) JPS535287B1 (en)
AT (3) AT303005B (en)
BE (1) BE746107A (en)
CA (1) CA945172A (en)
CH (3) CH547257A (en)
CS (3) CS153064B2 (en)
DE (1) DE2007751C2 (en)
DK (1) DK135278B (en)
ES (1) ES376788A1 (en)
FI (1) FI53120C (en)
FR (1) FR2034561A1 (en)
IE (1) IE34003B1 (en)
IL (1) IL33931A (en)
KE (1) KE2582A (en)
NL (1) NL162363C (en)
NO (1) NO128653B (en)
PL (3) PL87019B1 (en)
SE (1) SE391517B (en)
SU (3) SU482943A3 (en)
YU (4) YU34275B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1311521A (en) * 1970-02-13 1973-03-28 Ici Ltd Alkanolamine derivatives
DE2048838A1 (en) * 1970-10-05 1972-04-06 C H Boehnnger Sohn, 6507 Ingel heim New 1 phenoxy 2 hydroxy 3 hydroxyal kylaminopropane and process for their manufacture
FR2132570B1 (en) * 1971-04-09 1974-08-02 Lipha
GB1387630A (en) * 1971-05-07 1975-03-19 Ici Ltd Phenoxyalkanolamine derivatives
GB1433595A (en) * 1972-07-06 1976-04-28 Ici Ltd Alkanolamine derivatives
DE2623314C2 (en) * 1976-05-25 1984-08-02 Hoechst Ag, 6230 Frankfurt 1-aryloxy-2-hydroxy-3-aminopropanes, processes for their preparation and pharmaceuticals containing them
DE2818999A1 (en) * 1978-04-29 1979-11-15 Basf Ag AMINO DERIVATIVES OF 3-ALKYL-5- (2-HYDROXYSTYRYL) -ISOXAZOLES
DE2943405A1 (en) 1979-10-26 1981-05-07 Basf Ag, 6700 Ludwigshafen NEW AMINO DERIVATIVES OF 5- (2-HYDROXYSTYRYL) -ISOXAZOLE
US4593119A (en) * 1980-11-28 1986-06-03 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
JPS57105206U (en) * 1980-12-16 1982-06-29
DE3407695A1 (en) * 1984-03-02 1985-09-12 Röhm Pharma GmbH, 6108 Weiterstadt PTERIDINE COMPOUNDS WITH PHARMACEUTICAL EFFECTIVENESS
DE3500761A1 (en) * 1985-01-11 1986-09-04 SOUR "PODRAVKA" OOUR "BELUPO 2", Proizvodnja kozmetičkih preparata i lijekova, Koprivnica Process for the production of atenolol and its derivatives
US4971959A (en) * 1987-04-14 1990-11-20 Warner-Lambert Company Trisubstituted phenyl analogs having activity for congestive heart failure
EP0673924A4 (en) * 1992-12-10 1996-04-24 Teikoku Chem Ind Co Ltd Propionic acid derivative.
JP2001524114A (en) * 1997-04-30 2001-11-27 イーライ・リリー・アンド・カンパニー Intermediates and methods in the production of benzo [b] thiophenes
JP5225574B2 (en) * 2006-11-09 2013-07-03 エムキュア ファーマシューティカルズ リミテッド Improved process for the preparation of beta-blocker compounds
US8552036B2 (en) 2009-01-12 2013-10-08 Hetero Research Foundation Polymorph of atazanavir sulfate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593762A1 (en) * 1967-02-06 1972-06-08 Boehringer Sohn Ingelheim Process for the preparation of new substituted 1-phenoxy-2-hydroxy-3-alkylaminopropanes

Also Published As

Publication number Publication date
SE391517B (en) 1977-02-21
CS153062B2 (en) 1974-02-22
NO128653B (en) 1973-12-27
DE2007751C2 (en) 1983-12-15
YU193675A (en) 1978-10-31
FI53120C (en) 1978-02-10
NL162363B (en) 1979-12-17
DK135278C (en) 1977-09-12
NL162363C (en) 1980-05-16
YU41070A (en) 1978-10-31
CS153064B2 (en) 1974-02-22
IE34003B1 (en) 1975-01-08
KE2582A (en) 1975-12-05
CH547257A (en) 1974-03-29
SU493062A3 (en) 1975-11-25
PL93998B1 (en) 1977-07-30
YU193475A (en) 1978-10-31
CS153069B2 (en) 1974-02-22
FI53120B (en) 1977-10-31
PL87019B1 (en) 1976-06-30
PL77781B1 (en) 1975-04-30
AT305249B (en) 1973-02-12
YU193375A (en) 1978-10-31
NL7002414A (en) 1970-08-25
IL33931A (en) 1974-01-14
JPS535287B1 (en) 1978-02-25
BE746107A (en) 1970-08-17
YU34281B (en) 1979-04-30
FR2034561B1 (en) 1974-05-24
JPS5037182B1 (en) 1975-12-01
AT303005B (en) 1972-11-10
YU34279B (en) 1979-04-30
FR2034561A1 (en) 1970-12-11
AT305244B (en) 1973-02-12
SU482943A3 (en) 1975-08-30
IE34003L (en) 1970-08-21
CA945172A (en) 1974-04-09
IL33931A0 (en) 1970-04-20
DK135278B (en) 1977-03-28
CH561175A5 (en) 1975-04-30
YU34278B (en) 1979-04-30
YU34275B (en) 1979-04-30
DE2007751A1 (en) 1970-09-10
CH553747A (en) 1974-09-13
SU537626A3 (en) 1976-11-30

Similar Documents

Publication Publication Date Title
ES376788A1 (en) Procedure for the preparation of alcanolamine derivation. (Machine-translation by Google Translate, not legally binding)
ES358534A2 (en) Procedure for the manufacture of alcanolamine derivatives (Machine-translation by Google Translate, not legally binding)
GB1398412A (en) Piperidine derivatives
ES307376A1 (en) Procedure for the manufacture of 1-glicosil-5-azacitosinas. (Machine-translation by Google Translate, not legally binding)
ES393496A1 (en) Cerivatives of 2-pyrrolidinone
GB925429A (en) Indole derivatives
ES347178A1 (en) N-aromatic substituted acid amides
ES469926A1 (en) Methylmethioninesulfonium compounds, process for their preparation, and pharmaceutical compositions containing them
GB966222A (en) Derivatives of cephalosporin c
ES431673A1 (en) 7-methoxycephalosporins
GB1408198A (en) Antiviral compositions
SE7608306L (en) NEW 5-FLUOROPYRIMIDIN-4-ON DERIVATIVES
ES388245A1 (en) Alkanolamine derivatives
GB1192862A (en) Alkoxymethylamide Derivatives of Esters and/or Amides of Acids of Phosphorus
ES328566A1 (en) A procedure for the preparation of compounds given of anti-inflammatory properties. (Machine-translation by Google Translate, not legally binding)
ES395766A1 (en) Procedure for the obtaining of derivatives of hidantoin. (Machine-translation by Google Translate, not legally binding)
ES325861A1 (en) Procedure for the synthesis of phenyl derivatives. (Machine-translation by Google Translate, not legally binding)
ES397453A1 (en) Imidazoline derivatives of benzonorbornane and tetrahydronaphthalene compounds
SE7503560L (en)
ES365218A1 (en) Beta-alkoxy-acrylic acid amides
ES412061A1 (en) Phenoxypropylamine derivatives and the preparation thereof
ES389882A1 (en) 3-benzazepines and salts thereof
ES393340A1 (en) Amines and a process for the manufacture thereof
ES329025A1 (en) Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)
ES417884A1 (en) Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them