GB1311521A - Alkanolamine derivatives - Google Patents
Alkanolamine derivativesInfo
- Publication number
- GB1311521A GB1311521A GB710470A GB1311521DA GB1311521A GB 1311521 A GB1311521 A GB 1311521A GB 710470 A GB710470 A GB 710470A GB 1311521D A GB1311521D A GB 1311521DA GB 1311521 A GB1311521 A GB 1311521A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- reacting
- alkyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1311521 Alkanolamine derivatives IMPERIAL CHEMICAL INDUSTRIES Ltd 19 April 1971 [13 Feb 1970] 7104/70 Heading C2C [Also in Division A5] Compounds of the general formula (I) (R<SP>1</SP> = alkyl, hydroxyalkyl, aralkyl, cycloalkyl; R<SP>2</SP> = acyl; R<SP>3</SP> = H, halogen, alkyl, alkenyl, NO 2 , OH, alkylthio, alkoxy, alkenyloxy, aralkoxy, acyl, amino, acylamino, CN; A = alkylene), esters and aldehyde condensation products thereof, and their acid addition salts are prepared by (a) reacting a compound of the Formula (II) (X = oxiranyl and/or CHOHCH 2 Y, wherein Y stands for a displaceable radical) with R<SP>1</SP>NH 2 , (b) reacting a compound of the Formula (III) with R<SP>1</SP>NHCH 2 X, (c) hydrogenolysing a compound of the Formula (IV) (R<SP>6</SP> = hydrogenolysable radical) or acid addition salt thereof, (d) reacting a compound of the Formula (V) or acid addition salt thereof with a reactive ester of R<SP>1</SP>OH or with R<SP>7</SP>COR<SP>8</SP> (R<SP>7</SP> = alkyl; R<SP>8</SP> = alkyl, aralkyl, hydroxyalkyl; or CHR<SP>7</SP>R<SP>8</SP> = cycloalkyl) under reducing conditions, (e) acylating a compound of the Formula (VI) (f) hydrolysing a compound of the Formula (VII) (R<SP>9+10</SP> = O; or R<SP>9</SP> = H; R<SP>10</SP> = H, alkyl, aryl), (g) esterifying an acid addition salt of the corresponding alkanolamine, (h) reacting the corresponding alkanolamine or acid addition salt thereof with an aldehyde, (i) reacting a compound of the Formula (II), X = oxiranyl, with R<SP>1</SP>N = CHR<SP>10</SP> or (j) reacting a compound of the Formula (III) with a compound of the Formula (VIII) (R<SP>4</SP> = R<SP>10</SP>), optionally followed in each case by salt formation. The preparation of starting materials for processes (a), (b) and (c) and 3-methoxy-, ethoxy- and chloro-4-hydroxybenzaldehyde oxime, 2-hydroxybenzaldehyde oxime hydrochloride, 3- aminomethylphenol, 2 - chloro - 4 - aminomethylphenol and its hydrochloride and allyl 4 - acetamido - and propionamido - methylphenyl ether is described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB710470 | 1970-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1311521A true GB1311521A (en) | 1973-03-28 |
Family
ID=9826694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB710470A Expired GB1311521A (en) | 1970-02-13 | 1970-02-13 | Alkanolamine derivatives |
Country Status (16)
| Country | Link |
|---|---|
| AT (3) | AT310142B (en) |
| BE (1) | BE762902A (en) |
| CA (1) | CA979010A (en) |
| CH (3) | CH547260A (en) |
| DE (1) | DE2106816A1 (en) |
| DK (1) | DK130288B (en) |
| ES (1) | ES388245A1 (en) |
| FR (1) | FR2081513B1 (en) |
| GB (1) | GB1311521A (en) |
| HU (1) | HU162812B (en) |
| IE (1) | IE34929B1 (en) |
| IL (1) | IL36155A (en) |
| NL (1) | NL7101817A (en) |
| NO (1) | NO131984C (en) |
| SU (2) | SU431668A3 (en) |
| ZA (1) | ZA71711B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1005334A1 (en) * | 1997-04-23 | 2000-06-07 | Cornell Research Foundation, Inc. | Neuroprotective compounds and uses thereof |
| CN107266341A (en) * | 2017-06-23 | 2017-10-20 | 华东师范大学 | The derivative of the hydramine of aryloxy group substitution the third 2 is used as beta 3 adrenoreceptor antagonist, preparation method and purposes |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989004297A1 (en) * | 1986-08-19 | 1989-05-18 | Warner-Lambert Company | 4'-hydroxybenzylamine derivatives having anti-inflammatory and analgesic activity |
| US4980366A (en) * | 1986-08-19 | 1990-12-25 | Warner-Lambert Co. | Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1199037A (en) * | 1967-09-27 | 1970-07-15 | Ici Ltd | Alkanolamine Derivatives |
| CA945172A (en) * | 1969-02-21 | 1974-04-09 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
-
1970
- 1970-02-13 GB GB710470A patent/GB1311521A/en not_active Expired
-
1971
- 1971-02-03 IE IE130/71A patent/IE34929B1/en unknown
- 1971-02-04 CA CA104,508A patent/CA979010A/en not_active Expired
- 1971-02-04 ZA ZA710711A patent/ZA71711B/en unknown
- 1971-02-08 IL IL36155A patent/IL36155A/en unknown
- 1971-02-11 NL NL7101817A patent/NL7101817A/xx unknown
- 1971-02-12 HU HUIE430A patent/HU162812B/hu unknown
- 1971-02-12 NO NO523/71A patent/NO131984C/no unknown
- 1971-02-12 CH CH1499973A patent/CH547260A/en not_active IP Right Cessation
- 1971-02-12 CH CH1500073A patent/CH547261A/en not_active IP Right Cessation
- 1971-02-12 FR FR7104799A patent/FR2081513B1/fr not_active Expired
- 1971-02-12 BE BE762902A patent/BE762902A/en unknown
- 1971-02-12 SU SU1798742A patent/SU431668A3/ru active
- 1971-02-12 DE DE19712106816 patent/DE2106816A1/en active Pending
- 1971-02-12 DK DK64471AA patent/DK130288B/en unknown
- 1971-02-12 SU SU1618205A patent/SU400079A3/ru active
- 1971-02-12 CH CH209171A patent/CH544067A/en not_active IP Right Cessation
- 1971-02-13 ES ES388245A patent/ES388245A1/en not_active Expired
- 1971-02-15 AT AT355272A patent/AT310142B/en not_active IP Right Cessation
- 1971-02-15 AT AT129071A patent/AT307385B/en not_active IP Right Cessation
- 1971-02-15 AT AT355372A patent/AT310143B/en not_active IP Right Cessation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1005334A1 (en) * | 1997-04-23 | 2000-06-07 | Cornell Research Foundation, Inc. | Neuroprotective compounds and uses thereof |
| EP1005334A4 (en) * | 1997-04-23 | 2001-09-19 | Cornell Res Foundation Inc | Neuroprotective compounds and uses thereof |
| CN107266341A (en) * | 2017-06-23 | 2017-10-20 | 华东师范大学 | The derivative of the hydramine of aryloxy group substitution the third 2 is used as beta 3 adrenoreceptor antagonist, preparation method and purposes |
| CN107266341B (en) * | 2017-06-23 | 2020-01-07 | 华东师范大学 | Aryloxy substituted propan-2-ol amine derivative as beta3 adrenergic receptor antagonist, preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2081513B1 (en) | 1974-08-02 |
| IE34929L (en) | 1971-08-13 |
| CH544067A (en) | 1973-11-15 |
| AT310143B (en) | 1973-09-25 |
| AT307385B (en) | 1973-05-25 |
| DK130288C (en) | 1975-06-30 |
| IL36155A0 (en) | 1971-04-28 |
| ZA71711B (en) | 1971-10-27 |
| AT310142B (en) | 1973-09-25 |
| CH547260A (en) | 1974-03-29 |
| BE762902A (en) | 1971-08-12 |
| IL36155A (en) | 1974-06-30 |
| DE2106816A1 (en) | 1971-08-19 |
| SU400079A3 (en) | 1973-10-03 |
| SU431668A3 (en) | 1974-06-05 |
| ES388245A1 (en) | 1973-05-01 |
| IE34929B1 (en) | 1975-10-01 |
| CH547261A (en) | 1974-03-29 |
| NL7101817A (en) | 1971-08-17 |
| CA979010A (en) | 1975-12-02 |
| NO131984C (en) | 1975-09-03 |
| NO131984B (en) | 1975-05-26 |
| FR2081513A1 (en) | 1971-12-03 |
| HU162812B (en) | 1973-04-28 |
| DK130288B (en) | 1975-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |