GB1283887A - Acid amides - Google Patents

Acid amides

Info

Publication number
GB1283887A
GB1283887A GB20880/71A GB2088071A GB1283887A GB 1283887 A GB1283887 A GB 1283887A GB 20880/71 A GB20880/71 A GB 20880/71A GB 2088071 A GB2088071 A GB 2088071A GB 1283887 A GB1283887 A GB 1283887A
Authority
GB
United Kingdom
Prior art keywords
amide
vitamin
acid
acid amides
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20880/71A
Inventor
W Bollag
R Ruegg
G Ryser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1283887A publication Critical patent/GB1283887A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1283887 Vitamin A acid amides F HOFFMANN-LA ROCHE & CO AG 19 April 1971 [2 Feb 1970] 20880/71 Heading C2V Vitamin A acid amides of formula where R and R<SP>1</SP> are alkyl, alkyl substituted by alkoxy, alkyl substituted by dialkyl amino, hydroxy alkyl, phenyl or benzyl groups, are obtained by reacting Vitamin A acid or functional derivative thereof (e.g. an acid halide) with an amine of formula In examples there are prepared Vitamin A acid ethyl amide, methyl amide, isopropyl amide, butyl amide, methyl propyl amide, n-decyl amide, ethanol amide, phenyl amide, diphenyl amide, benzyl amide, 2-diethylamino-ethyl amide, 2-methoxy-ethyl amide, diethyl amide, di-(n-butyl) amide and di-(n-decyl) amide. The above-described Vitamin A acid amides may be formed into pharmaceutical preparations with the usual compatible carrier materials.
GB20880/71A 1970-02-02 1971-04-19 Acid amides Expired GB1283887A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH142870A CH529742A (en) 1970-02-02 1970-02-02 Process for the production of vitamin A acid amides

Publications (1)

Publication Number Publication Date
GB1283887A true GB1283887A (en) 1972-08-02

Family

ID=4210229

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20880/71A Expired GB1283887A (en) 1970-02-02 1971-04-19 Acid amides

Country Status (18)

Country Link
JP (1) JPS544948B1 (en)
AT (1) AT303274B (en)
BE (1) BE762345A (en)
CA (1) CA963910A (en)
CH (1) CH529742A (en)
DE (1) DE2102586C2 (en)
DK (1) DK136311B (en)
ES (1) ES387834A1 (en)
FI (1) FI52715C (en)
FR (1) FR2081477B1 (en)
GB (1) GB1283887A (en)
IE (1) IE35133B1 (en)
IL (1) IL35987A (en)
NL (1) NL168415C (en)
NO (1) NO133802C (en)
SE (1) SE373133B (en)
YU (1) YU34355B (en)
ZA (1) ZA71142B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007019503A2 (en) * 2005-08-08 2007-02-15 President And Fellows Of Harvard College Management of ophthalmologic disorders, including macular degeneration
KR100837186B1 (en) * 2006-09-29 2008-06-13 (주)아모레퍼시픽 Retinoic acid derivative having anti-aging activity and preparation method thereof
WO2018217873A1 (en) 2017-05-23 2018-11-29 The Regents Of The University Of Michigan Dimethyl-nonatetraenyl-trimethyl-cyclohexyl compounds and uses thereof

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2300107C2 (en) * 1973-01-03 1982-03-11 Basf Ag, 6700 Ludwigshafen Vitamin A acid anilide-4-carboxylic acid ethyl ester, process for its production and preparations containing it
US4310546A (en) * 1978-07-31 1982-01-12 Johnson & Johnson Novel retinoids and their use in preventing carcinogenesis
DE2843915A1 (en) * 1978-10-07 1980-04-24 Basf Ag N-BENZOYL RETINYLAMINE
DE2843870A1 (en) * 1978-10-07 1980-04-24 Basf Ag N-HYDROXYPROPYLAMIDES OF ALL-E AND 13-Z RETINIC ACID
DE3002545A1 (en) * 1980-01-25 1981-07-30 Basf Ag, 6700 Ludwigshafen 5-AMINO-TETRAZOLE DERIVATIVES OF RETINIC ACIDS, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
CH651007A5 (en) * 1982-06-24 1985-08-30 Hoffmann La Roche POLYEN CONNECTIONS.
WO1997009307A1 (en) * 1995-09-01 1997-03-13 Gist-Brocades B.V. Retinoylamide based derivatives of sphingoid bases
KR20070038509A (en) * 2004-07-09 2007-04-10 디에스엠 아이피 어셋츠 비.브이. Amino, amino acid or peptide conjugates of retinoic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH195065A (en) * 1936-11-23 1938-01-15 Int Suiker En Alcohol Compagni Installation on vacuum apparatus to facilitate the replacement of individual tubes.
FR1297730A (en) * 1960-11-04 1962-07-06 Hoffmann La Roche Cosmetic preparation
NL257621A (en) * 1959-11-23
FR1320153A (en) * 1962-01-22 1963-03-08 Sumitomo Chemical Co Process for the production of compounds derived from vitamin a 2-trans acid

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7566808B2 (en) 2004-02-17 2009-07-28 President And Fellows Of Harvard College Management of ophthalmologic disorders, including macular degeneration
WO2007019503A2 (en) * 2005-08-08 2007-02-15 President And Fellows Of Harvard College Management of ophthalmologic disorders, including macular degeneration
WO2007019503A3 (en) * 2005-08-08 2007-04-26 Harvard College Management of ophthalmologic disorders, including macular degeneration
KR100837186B1 (en) * 2006-09-29 2008-06-13 (주)아모레퍼시픽 Retinoic acid derivative having anti-aging activity and preparation method thereof
WO2018217873A1 (en) 2017-05-23 2018-11-29 The Regents Of The University Of Michigan Dimethyl-nonatetraenyl-trimethyl-cyclohexyl compounds and uses thereof
CN110831586A (en) * 2017-05-23 2020-02-21 密执安大学评议会 Dimethyl-nonatetraenyl-trimethyl-cyclohexyl compound and application thereof
EP3630083A4 (en) * 2017-05-23 2021-03-10 The Regents of The University of Michigan Dimethyl-nonatetraenyl-trimethyl-cyclohexyl compounds and uses thereof
US11148998B2 (en) 2017-05-23 2021-10-19 The Regents Of The University Of Michigan Dimethyl-nonatetraenyl-trimethyl-cyclohexyl compounds and uses thereof
CN110831586B (en) * 2017-05-23 2023-06-13 密执安大学评议会 Dimethyl-nonyltetraalkenyl-trimethyl-cyclohexyl compounds and uses thereof

Also Published As

Publication number Publication date
FI52715C (en) 1977-11-10
AT303274B (en) 1972-11-27
DE2102586C2 (en) 1985-03-14
FI52715B (en) 1977-08-01
IL35987A (en) 1974-01-14
JPS544948B1 (en) 1979-03-12
NO133802C (en) 1976-06-30
YU318470A (en) 1978-12-31
BE762345A (en) 1971-08-02
ZA71142B (en) 1971-10-27
FR2081477A1 (en) 1971-12-03
DK136311C (en) 1978-02-20
DE2102586A1 (en) 1971-08-12
FR2081477B1 (en) 1974-03-22
NL7018260A (en) 1971-08-04
SE373133B (en) 1975-01-27
IE35133B1 (en) 1975-11-26
ES387834A1 (en) 1973-06-01
NL168415C (en) 1982-04-16
DK136311B (en) 1977-09-26
NO133802B (en) 1976-03-22
CA963910A (en) 1975-03-04
YU34355B (en) 1979-07-10
IE35133L (en) 1971-08-02
CH529742A (en) 1972-10-31
IL35987A0 (en) 1971-03-24
NL168415B (en) 1981-11-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee