ES329025A1 - Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES329025A1
ES329025A1 ES0329025A ES329025A ES329025A1 ES 329025 A1 ES329025 A1 ES 329025A1 ES 0329025 A ES0329025 A ES 0329025A ES 329025 A ES329025 A ES 329025A ES 329025 A1 ES329025 A1 ES 329025A1
Authority
ES
Spain
Prior art keywords
general formula
compound
group
reaction
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0329025A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
J R GEYGI AG
Original Assignee
J R GEYGI AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J R GEYGI AG filed Critical J R GEYGI AG
Publication of ES329025A1 publication Critical patent/ES329025A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of new derivatives of acepine, of the general formula ** (See formula) ** in which R1 means a lower alkyl radical, R2 means hydrogen or the methyl radical, R3 and R4 mean hydrogen or lower alkyl radicals, or NR3 (R4) optionally means with the imino group, an alkilimino, hydroxyalkylimino or lower alkanoyloxyalkylimino group as a ring member, a 5-7 membered saturated heterocyclic radical, as well as its addition salts with inorganic or organic acids, characterized by that a stearate for reaction of a compound of the general formula II ** (See formula) ** wherein R1 and R2 have the same meaning indicated in Figure I, is reacted with a compound of the general formula III ** (See formula) ** in which R3 and R4 or NR3 (R4) have the same significance indicated in formula I, or with an N-acyl derivative of piperazine or hexahydro-1H-1,4-diazepine, or with a metal compound of an N-acyl derivative of a lower alkylamine; if necessary, the reaction product is subjected to hydrolysis for cleavage of an acyl radical, if desired, linked to a nitrogen atom of the side chain; if necessary, a compound of the general formula I with the imino group as ring member is treated with a lower alkylene oxide, with a monoester suitable for reaction of a lower alkanoiol or with an ester suitable for reaction of a lower alkanoyloxyalkanol; If desired, a compound of the general formula I with a lower hydroxyalkylimine group as the ring member is acylated to reach one of such compounds with a lower alkanoyloxyalkylimino group and, if desired, a compound of the general formula I is converted into a salt of Addition with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)
ES0329025A 1965-07-13 1966-07-12 Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding) Expired ES329025A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH979965A CH454873A (en) 1965-07-13 1965-07-13 Process for the production of new azepine derivatives
CH1044665A CH457446A (en) 1965-07-13 1965-07-26 Process for the production of new azepine derivatives

Publications (1)

Publication Number Publication Date
ES329025A1 true ES329025A1 (en) 1967-05-01

Family

ID=25705349

Family Applications (2)

Application Number Title Priority Date Filing Date
ES0329024A Expired ES329024A1 (en) 1965-07-13 1966-07-12 Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)
ES0329025A Expired ES329025A1 (en) 1965-07-13 1966-07-12 Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES0329024A Expired ES329024A1 (en) 1965-07-13 1966-07-12 Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)

Country Status (14)

Country Link
BE (1) BE684036A (en)
BR (1) BR6681206D0 (en)
CH (2) CH454873A (en)
DE (1) DE1695082A1 (en)
DK (2) DK113431B (en)
ES (2) ES329024A1 (en)
FI (1) FI43987C (en)
FR (2) FR1489912A (en)
GB (1) GB1099749A (en)
IL (1) IL26127A (en)
MY (1) MY7100125A (en)
NL (2) NL6609781A (en)
NO (1) NO120268B (en)
SE (1) SE324777B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH501650A (en) * 1968-12-19 1971-01-15 Ciba Geigy Ag Process for the production of new azepine derivatives
FR2201884B1 (en) * 1972-10-09 1975-11-28 Roussel Uclaf

Also Published As

Publication number Publication date
ES329024A1 (en) 1967-05-01
CH454873A (en) 1968-04-30
BR6681206D0 (en) 1973-12-26
NL133323C (en)
FI43987B (en) 1971-04-30
IL26127A (en) 1970-07-19
NO120268B (en) 1970-09-28
DK113587B (en) 1969-04-08
BE684036A (en) 1967-01-12
FI43987C (en) 1971-08-10
CH457446A (en) 1968-06-15
MY7100125A (en) 1971-12-31
FR6398M (en) 1968-10-21
NL6609781A (en) 1967-01-16
FR1489912A (en) 1967-07-28
SE324777B (en) 1970-06-15
GB1099749A (en) 1968-01-17
DE1695082A1 (en) 1970-08-13
DK113431B (en) 1969-03-24

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