ES314738A1 - Procedure for the preparation of new derivatives of oxepine. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of new oxepine derivatives of the general formula I, ** (See formula) ** in which X1, X3, Y1 and Y2 mean hydrogen, chlorine or bromine atoms, lower alkyl radicals or lower alkoxy radicals, R1 means hydrogen or the metal radical and R2 and R3 signify hydrogen or lower alkyl radicals or R2 and R3 form a heterocyclic radical saturated with 5-7 ring members, together with the adjacent nitrogen and optionally under inclusion of well-bonded oxygen, the imino group or an alkylimino group, hydroxyalkylimino or lower alkanoyloxyalkylimino as ring member, and salts thereof with inorganic and organic acids, characterized in that an ester capable of reacting, of a hydroxylic compound of the general formula II, ** (See formula) ** in which R1, X1, X2, Y1 and Y2 have the significance indicated above, is reacted with a compound of the general formula III, ** (See formula) ** in which R2 and R3 have the significance indicated above, or with a metal compound of an N-acyl derivative of a lower alkylamine, and in a desired manner the reaction product is subjected to hydrolysis to split an acyl radical linked at most to the Nitrogen of the side chain, and if desired a compound of the general formula I with the imino group as ring member is treated with a lower alkylene oxide, with a monoester capable of reacting a lower alkanoiol or with an ester capable of reaction of a lower alkanoyloxyalkyl, and if desired a compound of the general formula I with a lower hydroxyalkylimino group as a ring member is acylated with a lower alkanoyloxyalkylimino group to reach one such compound and, if desired, a compound of the general formula I It is transformed with an inorganic or organic acid in a salt. (Machine-translation by Google Translate, not legally binding)