ES329024A1 - Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES329024A1 ES329024A1 ES0329024A ES329024A ES329024A1 ES 329024 A1 ES329024 A1 ES 329024A1 ES 0329024 A ES0329024 A ES 0329024A ES 329024 A ES329024 A ES 329024A ES 329024 A1 ES329024 A1 ES 329024A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- acepine
- translation
- preparation
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Process for the preparation of new derivatives of acepine, of the general formula I ** (See formula) ** in which R1 means a lower alkyl radical, R2 means hydrogen or the methyl radical, R3 and R4 mean lower alkyl radicals or NR3 (R4) optionally means with a lower alkylimino or alkanoyloxyalkylimino group as a ring member, a saturated heterocyclic radical of 5-7 ring members, as well as their addition salts with inorganic or organic acids, characterized in that compounds of the general formula II ** (See formula) ** in which R2 has the significance indicated in formula I, R3 'or R4' or mean hydrogen or lower alkyl radicals, or [NR3 (R4)] 'optionally means with the imino group, an alkilimino or lower alkanoyloxyalkylimino group as a ring member, a saturated heterocyclic radical of 5-7 ring members, it is preferably alkylated in the presence of solvents and basic condensation agents with the aid of an ester suitable for the reaction of alkanols of the general formula III, R1 - OH (III) where R1 has the significance indicated in formula I, and the compounds obtained are optionally converted into their addition salts with inorganic or organic acids. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH979965A CH454873A (en) | 1965-07-13 | 1965-07-13 | Process for the production of new azepine derivatives |
CH1044665A CH457446A (en) | 1965-07-13 | 1965-07-26 | Process for the production of new azepine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES329024A1 true ES329024A1 (en) | 1967-05-01 |
Family
ID=25705349
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0329025A Expired ES329025A1 (en) | 1965-07-13 | 1966-07-12 | Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding) |
ES0329024A Expired ES329024A1 (en) | 1965-07-13 | 1966-07-12 | Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0329025A Expired ES329025A1 (en) | 1965-07-13 | 1966-07-12 | Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding) |
Country Status (14)
Country | Link |
---|---|
BE (1) | BE684036A (en) |
BR (1) | BR6681206D0 (en) |
CH (2) | CH454873A (en) |
DE (1) | DE1695082A1 (en) |
DK (2) | DK113431B (en) |
ES (2) | ES329025A1 (en) |
FI (1) | FI43987C (en) |
FR (2) | FR1489912A (en) |
GB (1) | GB1099749A (en) |
IL (1) | IL26127A (en) |
MY (1) | MY7100125A (en) |
NL (2) | NL6609781A (en) |
NO (1) | NO120268B (en) |
SE (1) | SE324777B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH505826A (en) * | 1968-12-19 | 1971-04-15 | Ciba Geigy Ag | Dibenzo-azepines |
FR2201884B1 (en) * | 1972-10-09 | 1975-11-28 | Roussel Uclaf |
-
0
- NL NL133323D patent/NL133323C/xx active
-
1965
- 1965-07-13 CH CH979965A patent/CH454873A/en unknown
- 1965-07-26 CH CH1044665A patent/CH457446A/en unknown
-
1966
- 1966-07-08 FI FI183166A patent/FI43987C/en active
- 1966-07-12 BE BE684036D patent/BE684036A/xx unknown
- 1966-07-12 NL NL6609781A patent/NL6609781A/xx unknown
- 1966-07-12 ES ES0329025A patent/ES329025A1/en not_active Expired
- 1966-07-12 DE DE19661695082 patent/DE1695082A1/en active Pending
- 1966-07-12 SE SE952966A patent/SE324777B/xx unknown
- 1966-07-12 GB GB31134/66A patent/GB1099749A/en not_active Expired
- 1966-07-12 NO NO16389166A patent/NO120268B/no unknown
- 1966-07-12 DK DK360666A patent/DK113431B/en unknown
- 1966-07-12 BR BR18120666A patent/BR6681206D0/en unknown
- 1966-07-12 ES ES0329024A patent/ES329024A1/en not_active Expired
- 1966-07-12 IL IL2612766A patent/IL26127A/en unknown
- 1966-07-13 FR FR69367A patent/FR1489912A/en not_active Expired
- 1966-10-11 FR FR79500A patent/FR6398M/fr not_active Expired
-
1967
- 1967-02-09 DK DK71767A patent/DK113587B/en unknown
-
1971
- 1971-12-31 MY MY7100125A patent/MY7100125A/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES329025A1 (en) | 1967-05-01 |
FR6398M (en) | 1968-10-21 |
NL6609781A (en) | 1967-01-16 |
NO120268B (en) | 1970-09-28 |
FR1489912A (en) | 1967-07-28 |
GB1099749A (en) | 1968-01-17 |
NL133323C (en) | |
BR6681206D0 (en) | 1973-12-26 |
FI43987C (en) | 1971-08-10 |
DK113431B (en) | 1969-03-24 |
IL26127A (en) | 1970-07-19 |
CH454873A (en) | 1968-04-30 |
MY7100125A (en) | 1971-12-31 |
FI43987B (en) | 1971-04-30 |
SE324777B (en) | 1970-06-15 |
DK113587B (en) | 1969-04-08 |
DE1695082A1 (en) | 1970-08-13 |
CH457446A (en) | 1968-06-15 |
BE684036A (en) | 1967-01-12 |
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