ES329024A1 - Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES329024A1
ES329024A1 ES0329024A ES329024A ES329024A1 ES 329024 A1 ES329024 A1 ES 329024A1 ES 0329024 A ES0329024 A ES 0329024A ES 329024 A ES329024 A ES 329024A ES 329024 A1 ES329024 A1 ES 329024A1
Authority
ES
Spain
Prior art keywords
formula
acepine
translation
preparation
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0329024A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES329024A1 publication Critical patent/ES329024A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11

Abstract

Process for the preparation of new derivatives of acepine, of the general formula I ** (See formula) ** in which R1 means a lower alkyl radical, R2 means hydrogen or the methyl radical, R3 and R4 mean lower alkyl radicals or NR3 (R4) optionally means with a lower alkylimino or alkanoyloxyalkylimino group as a ring member, a saturated heterocyclic radical of 5-7 ring members, as well as their addition salts with inorganic or organic acids, characterized in that compounds of the general formula II ** (See formula) ** in which R2 has the significance indicated in formula I, R3 'or R4' or mean hydrogen or lower alkyl radicals, or [NR3 (R4)] 'optionally means with the imino group, an alkilimino or lower alkanoyloxyalkylimino group as a ring member, a saturated heterocyclic radical of 5-7 ring members, it is preferably alkylated in the presence of solvents and basic condensation agents with the aid of an ester suitable for the reaction of alkanols of the general formula III, R1 - OH (III) where R1 has the significance indicated in formula I, and the compounds obtained are optionally converted into their addition salts with inorganic or organic acids. (Machine-translation by Google Translate, not legally binding)
ES0329024A 1965-07-13 1966-07-12 Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding) Expired ES329024A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH979965A CH454873A (en) 1965-07-13 1965-07-13 Process for the production of new azepine derivatives
CH1044665A CH457446A (en) 1965-07-13 1965-07-26 Process for the production of new azepine derivatives

Publications (1)

Publication Number Publication Date
ES329024A1 true ES329024A1 (en) 1967-05-01

Family

ID=25705349

Family Applications (2)

Application Number Title Priority Date Filing Date
ES0329024A Expired ES329024A1 (en) 1965-07-13 1966-07-12 Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)
ES0329025A Expired ES329025A1 (en) 1965-07-13 1966-07-12 Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES0329025A Expired ES329025A1 (en) 1965-07-13 1966-07-12 Procedure for the preparation of new derivatives of acepine. (Machine-translation by Google Translate, not legally binding)

Country Status (14)

Country Link
BE (1) BE684036A (en)
BR (1) BR6681206D0 (en)
CH (2) CH454873A (en)
DE (1) DE1695082A1 (en)
DK (2) DK113431B (en)
ES (2) ES329024A1 (en)
FI (1) FI43987C (en)
FR (2) FR1489912A (en)
GB (1) GB1099749A (en)
IL (1) IL26127A (en)
MY (1) MY7100125A (en)
NL (2) NL6609781A (en)
NO (1) NO120268B (en)
SE (1) SE324777B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505826A (en) * 1968-12-19 1971-04-15 Ciba Geigy Ag Dibenzo-azepines
FR2201884B1 (en) * 1972-10-09 1975-11-28 Roussel Uclaf

Also Published As

Publication number Publication date
DK113431B (en) 1969-03-24
CH454873A (en) 1968-04-30
CH457446A (en) 1968-06-15
BR6681206D0 (en) 1973-12-26
BE684036A (en) 1967-01-12
FR6398M (en) 1968-10-21
FI43987B (en) 1971-04-30
SE324777B (en) 1970-06-15
MY7100125A (en) 1971-12-31
DE1695082A1 (en) 1970-08-13
IL26127A (en) 1970-07-19
FR1489912A (en) 1967-07-28
DK113587B (en) 1969-04-08
ES329025A1 (en) 1967-05-01
NL6609781A (en) 1967-01-16
NL133323C (en)
FI43987C (en) 1971-08-10
GB1099749A (en) 1968-01-17
NO120268B (en) 1970-09-28

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