ES407851A1 - Penicillins their production and their medicinal use - Google Patents
Penicillins their production and their medicinal useInfo
- Publication number
- ES407851A1 ES407851A1 ES407851A ES407851A ES407851A1 ES 407851 A1 ES407851 A1 ES 407851A1 ES 407851 A ES407851 A ES 407851A ES 407851 A ES407851 A ES 407851A ES 407851 A1 ES407851 A1 ES 407851A1
- Authority
- ES
- Spain
- Prior art keywords
- see formula
- carbon atoms
- formula
- group
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 3
- 150000002960 penicillins Chemical class 0.000 title abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 10
- 150000001875 compounds Chemical class 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
- 229920002554 vinyl polymer Polymers 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- -1 acetone Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003609 aryl vinyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Abstract
Procedure for obtaining penicillins, of general formula I **(See formula)** in which A represents a group **(See formula)** X represents a group (see formula), And a group (see formula), Z a group (see formula), Q1 a group (see formula) and Q2 a group **(See formula)** in which formulas represent: R a linear or branched alkyl radical with up to 5 carbon atoms, hydrogen, provided that X is not at the same time -CO-, alkyl with up to 10 carbon atoms, cycloalkenyl with up to 10 carbon atoms, cycloalkenyl with up to 10 carbon atoms, vinyl, aryl vinyl, monohalogeno lower alkyl, dihalogeno lower alkyl, trihalogeno lower alkyl H2N-, R-NH-, (see formula), aryl-NH-, arylalkyl (lower) -amino, alkoxy with up to 8 carbon atoms, provided that X is not at the same time -SO2-, aralkoxy with up to 8 carbon atoms, provided that X is not at the same time -SO2-, cycloalkoxy with up to 7 carbon atoms, provided that X is not at the same time -SO2-, aryloxy, provided that X is not at the same time -SO2-, one of the groups ROV-, RSV-, N = CV-, RO-CO-V-, H2N-CO-V-, R-NH-CO-V-, (see formula), **(See formula)** V a bivalent organic radical with 1 to 3 carbon atoms, n an integer from 0 to 2 inclusive, R2 and R3 each represent hydrogen, alkyl and alkenyl each with up to 8 carbon, vinyl, ring, propenyl, cycloalkyl atoms And cycloalkenyl each having up to 6 carbon atoms, mono-, di- and trihalogenoalkyl or aryl, R4, R5 and R6 each represent hydrogen, nitro, nitrile, (see formula), (see formula), R-CO-NH-, RO-CO-, R-CO-O-, R-, RO-, H2N-SO2-, chlorine, bromine, iodine, fluorine or trifluoromethyl, and G represents hydrogen or R, meaning the arrow on the divalent intermediate piece (see formula) that the ligation of two atoms caused by the two free valences of this intermediate piece is not arbitrary, but must proceed in the way characterized by the arrow, B is a group of the formula **(See formula)** R7, R8 and R9 represent hydrogen, halogen, R-, R-O-, R-S-, R-SO-, R-SO2-, nitro, (see formula), R-CO-NH-, HO, R-CO-O-, having R the meaning indicated above, and its non-toxic pharmaceutically acceptable salts, the penicillins of the general formula I and their non-toxic pharmaceutically tolerable salts being able to present, regarding the chirality center (see formula), in the two possible configurations R and S and as mixtures of the resulting diastereomers; characterized in that a compound chosen from compounds of general formula II is reacted **(See formula)** and the condensation products of compounds of the general formula II with carbonyl compounds, such as acetone, chosen from compounds of the general formula III **(See formula)** and compounds of general formulas IV and V **(See formula)** in which formulas B and G have the meanings indicated above and R10, R11 and R12 represent alkyl with up to 6 carbon atoms, with compounds chosen from the general formulas VI, VII, VIII, IX and X **(See formula)** in which A, Q1, Q2, R1, R2, X, Y and Z have the meanings indicated above, and W represents halogen, azide or a group (see formula), the reaction being carried out, in the case of the application of the compounds of the general formulas II and III, in anhydrous or aqueous solvents, in the presence of a base, and in the case of the application of compounds of the formulas General IV and V, in anhydrous and hydroxyl group-free solvents with or without the addition of a base, at temperatures in the range of about -50º to + 50ºC. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2152967A DE2152967C3 (en) | 1971-10-23 | 1971-10-23 | Acylureidopenicillins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES407851A1 true ES407851A1 (en) | 1975-10-01 |
Family
ID=5823251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES407851A Expired ES407851A1 (en) | 1971-10-23 | 1972-10-21 | Penicillins their production and their medicinal use |
Country Status (31)
| Country | Link |
|---|---|
| JP (2) | JPS55391B2 (en) |
| AR (1) | AR195805A1 (en) |
| AT (1) | AT320152B (en) |
| BE (1) | BE790440A (en) |
| BG (2) | BG21609A3 (en) |
| CA (1) | CA1019323A (en) |
| CH (1) | CH579089A5 (en) |
| CS (1) | CS188883B2 (en) |
| CY (1) | CY947A (en) |
| DD (1) | DD106044B3 (en) |
| DE (1) | DE2152967C3 (en) |
| DK (1) | DK134992C (en) |
| EG (1) | EG10826A (en) |
| ES (1) | ES407851A1 (en) |
| FI (1) | FI56839C (en) |
| FR (1) | FR2157908B1 (en) |
| GB (1) | GB1392849A (en) |
| HK (1) | HK18578A (en) |
| HU (1) | HU167986B (en) |
| IE (1) | IE37123B1 (en) |
| IL (1) | IL40628A (en) |
| KE (1) | KE2824A (en) |
| LU (1) | LU66332A1 (en) |
| NO (1) | NO143909C (en) |
| PH (1) | PH9893A (en) |
| PL (2) | PL89056B1 (en) |
| RO (2) | RO63066A (en) |
| SE (1) | SE412236B (en) |
| SU (1) | SU527139A3 (en) |
| YU (1) | YU264072A (en) |
| ZA (1) | ZA727473B (en) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3978056A (en) * | 1971-10-23 | 1976-08-31 | Bayer Aktiengesellschaft | Penicillins |
| US3972869A (en) * | 1971-10-23 | 1976-08-03 | Bayer Aktiengesellschaft | Penicillins |
| US3983105A (en) * | 1971-10-23 | 1976-09-28 | Bayer Aktiengesellschaft | Penicillins |
| US3972870A (en) * | 1971-10-23 | 1976-08-03 | Bayer Aktiengesellschaft | Penicillins |
| NL175419C (en) * | 1971-10-23 | 1984-11-01 | Bayer Ag | METHOD FOR PREPARING OR MANUFACTURING ANTIBIOTIC ACTIVE PHARMACEUTICAL PREPARATIONS AND METHOD FOR PREPARING ANTIBIOTIC ACTIVE ALPHA-SUBSTITUTED 6- (ALFA- (3-ACYLUREIDO) -PETYL-ACIDYL-ACIDYL-ACIDYL) |
| US3974141A (en) * | 1971-10-23 | 1976-08-10 | Bayer Aktiengesellschaft | Penicillins |
| US3974142A (en) * | 1971-10-23 | 1976-08-10 | Bayer Aktiengesellschaft | Penicillins |
| US4009272A (en) * | 1971-10-23 | 1977-02-22 | Bayer Aktiengesellschaft | Penicillins |
| DE2258973A1 (en) * | 1972-12-01 | 1974-06-06 | Bayer Ag | PENICILLIN, THE METHOD FOR MANUFACTURING IT AND THEIR USE AS A MEDICINAL PRODUCT |
| JPS587637B2 (en) * | 1973-12-27 | 1983-02-10 | 住友化学工業株式会社 | Shinkipenicillin no Seihou |
| DE2407715C2 (en) * | 1974-02-18 | 1982-12-02 | Bayer Ag, 5090 Leverkusen | Cephalosporins, processes for their production, as well as pharmaceuticals |
| IL47168A (en) * | 1974-05-09 | 1979-07-25 | Toyama Chemical Co Ltd | Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same |
| DE2525541C2 (en) * | 1975-06-07 | 1984-01-12 | Bayer Ag, 5090 Leverkusen | β-lactam antibiotics, processes for their preparation and pharmaceuticals containing them |
| DE2810083A1 (en) | 1978-03-08 | 1979-09-20 | Bayer Ag | BETA-LACTAM COMPOUNDS |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| EP1780213A1 (en) * | 2005-10-27 | 2007-05-02 | 3M Innovative Properties Company | Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups |
| TWI417095B (en) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mglur2-receptors |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| CN101801951B (en) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones |
| AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
| EP2200985B1 (en) | 2007-09-14 | 2011-07-13 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
| CN101861316B (en) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
| ES2439291T3 (en) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | 3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors |
| JP5656848B2 (en) | 2008-10-16 | 2015-01-21 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | Indole and benzomorpholine derivatives as metabotropic glutamate receptor modulators |
| US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| MX2011011962A (en) | 2009-05-12 | 2012-02-28 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors. |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ME01573B (en) | 2009-05-12 | 2014-09-20 | Addex Pharma Sa | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| RU2016115906A (en) * | 2009-06-10 | 2018-11-28 | Текфилдз Байокем Ко., Лтд. | COMPOSITIONS OR MEDICATIONS OF ANTIMO-MICROBIAL AND RELATIVE ANTIMO-MICROBIAL COMPOUNDS Possessing a High Penetrating Ability |
| US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| JP5852666B2 (en) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor |
| AU2011328195B2 (en) | 2010-11-08 | 2015-04-02 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| JO3368B1 (en) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| JO3367B1 (en) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| PL3096790T3 (en) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| KR20200036063A (en) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1770620A1 (en) * | 1968-06-12 | 1971-11-11 | Bayer Ag | New penicillins |
-
0
- BE BE790440D patent/BE790440A/xx not_active IP Right Cessation
-
1971
- 1971-10-23 DE DE2152967A patent/DE2152967C3/en not_active Expired
-
1972
- 1972-10-12 SU SU1839113A patent/SU527139A3/en active
- 1972-10-17 RO RO197285500A patent/RO63066A/en unknown
- 1972-10-17 PH PH14018A patent/PH9893A/en unknown
- 1972-10-17 RO RO197272544A patent/RO60670A/ro unknown
- 1972-10-19 DD DD72166352A patent/DD106044B3/en unknown
- 1972-10-19 FI FI2897/72A patent/FI56839C/en active
- 1972-10-19 CS CS727048A patent/CS188883B2/en unknown
- 1972-10-19 HU HUBA2815A patent/HU167986B/hu not_active IP Right Cessation
- 1972-10-19 BG BG21665A patent/BG21609A3/xx unknown
- 1972-10-19 BG BG24757A patent/BG20813A3/xx unknown
- 1972-10-20 ZA ZA727473A patent/ZA727473B/en unknown
- 1972-10-20 CH CH1531272A patent/CH579089A5/xx not_active IP Right Cessation
- 1972-10-20 SE SE7213592A patent/SE412236B/en unknown
- 1972-10-20 DK DK522172A patent/DK134992C/en active
- 1972-10-20 AT AT901072A patent/AT320152B/en not_active IP Right Cessation
- 1972-10-20 CA CA154,338A patent/CA1019323A/en not_active Expired
- 1972-10-20 IL IL7240628A patent/IL40628A/en unknown
- 1972-10-20 LU LU66332A patent/LU66332A1/xx unknown
- 1972-10-20 IE IE1422/72A patent/IE37123B1/en unknown
- 1972-10-21 PL PL1972158392A patent/PL89056B1/pl unknown
- 1972-10-21 PL PL1972183057A patent/PL93574B1/pl unknown
- 1972-10-21 EG EG437/72A patent/EG10826A/en active
- 1972-10-21 JP JP10490172A patent/JPS55391B2/ja not_active Expired
- 1972-10-21 ES ES407851A patent/ES407851A1/en not_active Expired
- 1972-10-21 JP JP10490272A patent/JPS57843B2/ja not_active Expired
- 1972-10-23 FR FR7237482A patent/FR2157908B1/fr not_active Expired
- 1972-10-23 NO NO723810A patent/NO143909C/en unknown
- 1972-10-23 CY CY947A patent/CY947A/en unknown
- 1972-10-23 AR AR244770A patent/AR195805A1/en active
- 1972-10-23 GB GB4869972A patent/GB1392849A/en not_active Expired
- 1972-10-23 YU YU02640/72A patent/YU264072A/en unknown
-
1978
- 1978-03-14 KE KE2824A patent/KE2824A/en unknown
- 1978-04-04 HK HK185/78A patent/HK18578A/en unknown
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