ES398511A1 - Substituted gem-diaryl ethylene derivatives and therapeutic compositions thereof - Google Patents

Substituted gem-diaryl ethylene derivatives and therapeutic compositions thereof

Info

Publication number
ES398511A1
ES398511A1 ES398511A ES398511A ES398511A1 ES 398511 A1 ES398511 A1 ES 398511A1 ES 398511 A ES398511 A ES 398511A ES 398511 A ES398511 A ES 398511A ES 398511 A1 ES398511 A1 ES 398511A1
Authority
ES
Spain
Prior art keywords
group
formula
carbon atoms
see formula
alq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES398511A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of ES398511A1 publication Critical patent/ES398511A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for the preparation of substituted derivatives of gem-diaryl-ethylene, of general formula: **(See formula)** wherein R represents a phenyl group or a 2-thienyl group; R1 represents **(See formula)** wherein R2 represents an alkyl, cycloalkyl or cycloalkylalkyl group containing from 3 to 6 carbon atoms; and Y represents: (A) an aminoalkylidene group of the formula = CR5-alq-NR3R4 in which it represents a hydrogen atom or a methyl group, "alq" represents an ethylene, 1- or 2-methylethylene or tri-methylene group, with the proviso that = CR5-alq- does not contain more than 4 carbon atoms, and R3 and R4 each represent a lower alkyl group or, together with the nitrogen atom to which they are attached, form a saturated heterocyclic group; or (B) an amino-cyclic group of the formula **(See formula)** where n is 0 to 2, R5 is hydrogen, methyl or ethyl, provided that = CR5-CnH2n- does not contain more than 3 carbon atoms, and Z is a divalent group that completes a saturated heterocyclic ring containing as at least one nitrogen atom and at least 4 carbon atoms, any nitrogen atom of the aforementioned being separated from the carbon atom to which the amino-cyclic group is attached, by a chain of 3 or 4 carbon atoms; characterized by comprising reacting a ketone compound of the formula: **(See formula)** with a Grignard reagent chosen from the formulas: **(See formula)** where X represents a chlorine, bromine or iodine atom, dehydrate the resulting carbinol product and recover a compound of formula (I) as product. (Machine-translation by Google Translate, not legally binding)
ES398511A 1971-01-11 1971-12-31 Substituted gem-diaryl ethylene derivatives and therapeutic compositions thereof Expired ES398511A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB125271 1971-01-11

Publications (1)

Publication Number Publication Date
ES398511A1 true ES398511A1 (en) 1974-08-16

Family

ID=9718769

Family Applications (2)

Application Number Title Priority Date Filing Date
ES398510A Expired ES398510A1 (en) 1971-01-11 1971-12-31 Substituted gem-diaryl ethylene derivatives and therapeutic compositions thereof
ES398511A Expired ES398511A1 (en) 1971-01-11 1971-12-31 Substituted gem-diaryl ethylene derivatives and therapeutic compositions thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES398510A Expired ES398510A1 (en) 1971-01-11 1971-12-31 Substituted gem-diaryl ethylene derivatives and therapeutic compositions thereof

Country Status (7)

Country Link
AU (1) AU465190B2 (en)
BE (1) BE777849A (en)
CH (3) CH543476A (en)
DE (1) DE2162802A1 (en)
ES (2) ES398510A1 (en)
FR (1) FR2121719B1 (en)
GB (1) GB1320481A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046337A3 (en) * 1980-08-20 1982-09-15 Imperial Chemical Industries Plc Triazole compounds, a process for preparing them, their use as plant and pharmaceutical fungicides and as plant growth regulators and compositions containing them
ZA979781B (en) * 1996-11-14 1998-06-08 Akzo Nobel Nv Piperidine derivatives.
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) * 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE640572A (en) *
GB657301A (en) * 1948-02-25 1951-09-19 Wellcome Found Improvements in and relating to the preparation of substituted amino-alcohols and derivatives thereof

Also Published As

Publication number Publication date
FR2121719B1 (en) 1975-08-01
BE777849A (en) 1972-07-07
CH540880A (en) 1973-10-15
DE2162802A1 (en) 1972-09-21
AU465190B2 (en) 1975-09-18
CH543476A (en) 1973-12-14
FR2121719A1 (en) 1972-08-25
ES398510A1 (en) 1974-08-16
GB1320481A (en) 1973-06-13
CH555357A (en) 1974-10-31
AU3761772A (en) 1973-07-12

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