ES438637A1 - Indolinone and fluorenone derivatives - Google Patents

Indolinone and fluorenone derivatives

Info

Publication number
ES438637A1
ES438637A1 ES438637A ES438637A ES438637A1 ES 438637 A1 ES438637 A1 ES 438637A1 ES 438637 A ES438637 A ES 438637A ES 438637 A ES438637 A ES 438637A ES 438637 A1 ES438637 A1 ES 438637A1
Authority
ES
Spain
Prior art keywords
formula
group
indolinone
see formula
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES438637A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH838174A external-priority patent/CH602710A5/en
Priority claimed from CH838074A external-priority patent/CH599160A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES438637A1 publication Critical patent/ES438637A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/10—Radicals substituted by singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedure for preparing fluorenone derivatives of formula I: ** (See formula) ** where Het is a radical formed by separating one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, and R is group A, B, C or D: ** (See formula) ** where n is the number 2 or 3, n'is the number 1, 2,3 or 4, and XX' is ethylene or vinylene, where in group D each of the two carbon atoms adjacent to the nitrogen atom they are identically substituted by hydrogen or by one or two alkyl groups of 1 to 4 carbon atoms; characterized by the fact that a compound chosen from formulas lIa and IIb is reacted: ** (See formula) ** where Y is a separating group, with a compound of formula III: H - R III where R has the previously indicated meaning. (Machine-translation by Google Translate, not legally binding)
ES438637A 1974-06-19 1975-06-17 Indolinone and fluorenone derivatives Expired ES438637A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH838174A CH602710A5 (en) 1974-06-19 1974-06-19 Substd. 9-fluorenone and 2-indolinone derivs
CH838074A CH599160A5 (en) 1974-06-19 1974-06-19 Substd. 9-fluorenone and 2-indolinone derivs

Publications (1)

Publication Number Publication Date
ES438637A1 true ES438637A1 (en) 1977-06-01

Family

ID=25703229

Family Applications (1)

Application Number Title Priority Date Filing Date
ES438637A Expired ES438637A1 (en) 1974-06-19 1975-06-17 Indolinone and fluorenone derivatives

Country Status (18)

Country Link
JP (1) JPS51125060A (en)
AT (1) ATA466375A (en)
AU (1) AU8216875A (en)
CA (1) CA1036163A (en)
DD (1) DD118086A5 (en)
DE (1) DE2525656A1 (en)
DK (1) DK259475A (en)
ES (1) ES438637A1 (en)
FI (1) FI751727A (en)
FR (1) FR2275200A1 (en)
GB (1) GB1500063A (en)
HU (1) HU169926B (en)
IE (1) IE41562B1 (en)
IL (1) IL47503A0 (en)
NL (1) NL7507131A (en)
NO (1) NO752078L (en)
SE (1) SE7506757L (en)
SU (1) SU583755A3 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
KR100711840B1 (en) 1999-01-22 2007-05-02 엘란 파마슈티칼스, 인크. Acyl derivatives which treat VLA-4 related disorders
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
ATE493405T1 (en) 2005-09-29 2011-01-15 Elan Pharm Inc PYRIMIDINYLAMIDE COMPOUNDS THAT INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
CA2851103A1 (en) 2005-09-29 2007-04-12 Elan Pharmaceuticals, Inc. Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4
JP5135235B2 (en) 2006-02-27 2013-02-06 エラン ファーマシューティカルズ，インコーポレイテッド Pyrimidinylsulfonamide compounds that inhibit leukocyte adhesion mediated by VAL-4
MX2011011326A (en) 2009-04-27 2012-02-13 Elan Pharm Inc Pyridinone antagonists of alpha-4 integrins.

Also Published As

Publication number Publication date
CA1036163A (en) 1978-08-08
IL47503A0 (en) 1975-08-31
ATA466375A (en) 1979-08-15
DE2525656A1 (en) 1976-01-15
NL7507131A (en) 1975-12-23
HU169926B (en) 1977-02-28
FR2275200A1 (en) 1976-01-16
JPS51125060A (en) 1976-11-01
FI751727A (en) 1975-12-20
GB1500063A (en) 1978-02-08
IE41562B1 (en) 1980-01-30
DK259475A (en) 1975-12-20
AU8216875A (en) 1976-12-23
NO752078L (en) 1975-12-22
DD118086A5 (en) 1976-02-12
SE7506757L (en) 1975-12-22
FR2275200B1 (en) 1979-06-08
IE41562L (en) 1975-12-19
SU583755A3 (en) 1977-12-05

Similar Documents

Publication Publication Date Title
ES304839A1 (en) A procedure for preparing quaternary ammonium sulphomonometers. (Machine-translation by Google Translate, not legally binding)
GB1416848A (en) N-3-hydroxyaryl-propyl-imides
ES402057A1 (en) Compounds tetracloroftalidos cromogenicos (Machine-translation by Google Translate, not legally binding)
ES8300699A1 (en) Heterocyclic compounds
ES438637A1 (en) Indolinone and fluorenone derivatives
ES330164A1 (en) A procedure for preparing a triamide of a phosphorus acid. (Machine-translation by Google Translate, not legally binding)
ES443563A1 (en) 2-methoxy-benzamide derivatives
ES423104A1 (en) Procedure for preparing heterociclic anilides. (Machine-translation by Google Translate, not legally binding)
ES404745A1 (en) Cephalosporin compounds
ES400841A1 (en) 2-hydroxybenzophenones
ES395701A1 (en) Halogen substituted pyrininealdehyde phenyl hydrazones
ES402180A1 (en) 1-(3-pyridyl)-2-benzylthio-3-loweralkyl-isothio ureas and derivatives thereof
ES398511A1 (en) Substituted gem-diaryl ethylene derivatives and therapeutic compositions thereof
ES407059A1 (en) Tris-organotin sulfolenes and sulfolanes
ES427776A1 (en) Poly-phosphine oxide- flame-retardants
ES381487A1 (en) 3-n-alkylcarbamyl-oximino-heterocyclic compounds and their use in pesticidal compositions
ES427448A3 (en) Procedure for the preparation of N-tritilimidazoles (Machine-translation by Google Translate, not legally binding)
ES403237A1 (en) Iminoisoindolinone dyestuffs and process for their manufacture
ES390339A1 (en) Procedure for the preparation of new non-heterociclic mononuclear diglicidyl compounds. (Machine-translation by Google Translate, not legally binding)
ES334297A1 (en) Process for preparing benzodiazepines
ES432289A1 (en) Heterocyclic compounds
ES441029A1 (en) Acetylsalicylic acid derivatives their preparation and compo sitions containing them
ES435620A1 (en) A procedure for the preparation of new derivatives of tolipomycinone. (Machine-translation by Google Translate, not legally binding)
ES403547A1 (en) Novel substituted oxazino(5,6,e)indoles
ES441429A2 (en) Trisazo compounds