IE41562L - Indolinone and fluorenone derivatives - Google Patents
Indolinone and fluorenone derivativesInfo
- Publication number
- IE41562L IE41562L IE751359A IE135975A IE41562L IE 41562 L IE41562 L IE 41562L IE 751359 A IE751359 A IE 751359A IE 135975 A IE135975 A IE 135975A IE 41562 L IE41562 L IE 41562L
- Authority
- IE
- Ireland
- Prior art keywords
- indolinone
- fluorenone
- het
- fluorenone derivatives
- june
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
- C07D203/10—Radicals substituted by singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1500063 2-Indolinone and fluorenone derivatives SANDOZ Ltd 16 June 1975 [19 June 1974 (2)] 25530/75 Heading C2C Novel 2-indolinone and fluorenone derivatives of the general formula wherein Het is a radical formed by removing a hydrogen atom from the phenyl ring of 2-indolinone or fluorenone, and R is a group having one of the following Formulµ A, B, C and D in which n is 2 or 3, n<SP>1</SP> is 1-4, X-X<SP>1</SP> is ethylene or vinylene and in D the two C atoms adjacent to the N atom are identically unsubstituted or substituted by one or two C 1-4 alkyl groups and acid addition salts thereof are prepared by reacting Het-O-CH 2 -CH(OH)-CH 2 Y, in which Y is a leaving group, or an epoxy compound of the general Formula IIa with H-R, followed optionally by salification of the product. Pharmaceutical compositions having antiarrhythmic activity comprise, as active ingredient, a 2-indolinone or fluorenone derivative (I) or a pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutical carrier or diluent.
[GB1500063A]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH838074A CH599160A5 (en) | 1974-06-19 | 1974-06-19 | Substd. 9-fluorenone and 2-indolinone derivs |
CH838174A CH602710A5 (en) | 1974-06-19 | 1974-06-19 | Substd. 9-fluorenone and 2-indolinone derivs |
Publications (2)
Publication Number | Publication Date |
---|---|
IE41562L true IE41562L (en) | 1975-12-19 |
IE41562B1 IE41562B1 (en) | 1980-01-30 |
Family
ID=25703229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE1359/75A IE41562B1 (en) | 1974-06-19 | 1975-06-17 | Indolinone and fluorenone derivatives |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS51125060A (en) |
AT (1) | ATA466375A (en) |
AU (1) | AU8216875A (en) |
CA (1) | CA1036163A (en) |
DD (1) | DD118086A5 (en) |
DE (1) | DE2525656A1 (en) |
DK (1) | DK259475A (en) |
ES (1) | ES438637A1 (en) |
FI (1) | FI751727A (en) |
FR (1) | FR2275200A1 (en) |
GB (1) | GB1500063A (en) |
HU (1) | HU169926B (en) |
IE (1) | IE41562B1 (en) |
IL (1) | IL47503A0 (en) |
NL (1) | NL7507131A (en) |
NO (1) | NO752078L (en) |
SE (1) | SE7506757L (en) |
SU (1) | SU583755A3 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2960178D1 (en) * | 1978-06-06 | 1981-04-09 | Hoechst Ag | New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation |
JP4754693B2 (en) | 1999-01-22 | 2011-08-24 | エラン ファーマシューティカルズ,インコーポレイテッド | Acyl derivatives for treating VLA-4 related disorders |
TW200307671A (en) | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
TWI281470B (en) | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
BRPI0616687A2 (en) | 2005-09-29 | 2011-06-28 | Elan Pharm Inc | pyrimidinyl amide compounds that inhibit vla-4 mediated leukocyte adhesion |
EP1940827B1 (en) | 2005-09-29 | 2011-03-16 | Elan Pharmaceuticals Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 |
CA2643838A1 (en) | 2006-02-27 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4 |
BRPI1015259A2 (en) | 2009-04-27 | 2016-05-03 | Elan Pharm Inc | alpha-4 integrin pyridinone antagonists |
-
1975
- 1975-06-09 DE DE19752525656 patent/DE2525656A1/en active Pending
- 1975-06-10 DK DK259475A patent/DK259475A/en unknown
- 1975-06-10 FI FI751727A patent/FI751727A/fi unknown
- 1975-06-11 NO NO752078A patent/NO752078L/no unknown
- 1975-06-12 SE SE7506757A patent/SE7506757L/en unknown
- 1975-06-16 NL NL7507131A patent/NL7507131A/en not_active Application Discontinuation
- 1975-06-16 GB GB25530/75A patent/GB1500063A/en not_active Expired
- 1975-06-17 IL IL47503A patent/IL47503A0/en unknown
- 1975-06-17 DD DD186699A patent/DD118086A5/xx unknown
- 1975-06-17 AU AU82168/75A patent/AU8216875A/en not_active Expired
- 1975-06-17 IE IE1359/75A patent/IE41562B1/en unknown
- 1975-06-17 FR FR7518882A patent/FR2275200A1/en active Granted
- 1975-06-17 ES ES438637A patent/ES438637A1/en not_active Expired
- 1975-06-17 HU HUSA2805A patent/HU169926B/hu unknown
- 1975-06-18 JP JP50073280A patent/JPS51125060A/en active Pending
- 1975-06-18 AT AT466375A patent/ATA466375A/en not_active Application Discontinuation
- 1975-06-18 CA CA229,607A patent/CA1036163A/en not_active Expired
- 1975-06-19 SU SU7502145931A patent/SU583755A3/en active
Also Published As
Publication number | Publication date |
---|---|
SE7506757L (en) | 1975-12-22 |
DK259475A (en) | 1975-12-20 |
JPS51125060A (en) | 1976-11-01 |
FR2275200B1 (en) | 1979-06-08 |
ATA466375A (en) | 1979-08-15 |
CA1036163A (en) | 1978-08-08 |
FR2275200A1 (en) | 1976-01-16 |
ES438637A1 (en) | 1977-06-01 |
NO752078L (en) | 1975-12-22 |
DD118086A5 (en) | 1976-02-12 |
SU583755A3 (en) | 1977-12-05 |
NL7507131A (en) | 1975-12-23 |
AU8216875A (en) | 1976-12-23 |
FI751727A (en) | 1975-12-20 |
IL47503A0 (en) | 1975-08-31 |
DE2525656A1 (en) | 1976-01-15 |
HU169926B (en) | 1977-02-28 |
IE41562B1 (en) | 1980-01-30 |
GB1500063A (en) | 1978-02-08 |
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