ES425197A1 - Penicillanic acids their production and their medicinal use - Google Patents
Penicillanic acids their production and their medicinal useInfo
- Publication number
- ES425197A1 ES425197A1 ES425197A ES425197A ES425197A1 ES 425197 A1 ES425197 A1 ES 425197A1 ES 425197 A ES425197 A ES 425197A ES 425197 A ES425197 A ES 425197A ES 425197 A1 ES425197 A1 ES 425197A1
- Authority
- ES
- Spain
- Prior art keywords
- see formula
- group
- carbon atoms
- same time
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
Procedure for the production of crystalline penicillinic acids, of general formula I ** (See formula) ** in which they represent: A group ** (See formula) ** where they represent: X a group (see formula), And a group ** (See formula) ** in which last group R is a linear or branched alkyl radical with up to 5 carbon atoms, R a linear or branched alkyl radical with up to 5 carbon atoms, Z a group (see formula), Q a group (see formula), R1 alkyl with up to 6 carbon atoms (optionally substituted), alkenyl with up to 6 carbon atoms, cycloalkyl with up to 7 carbon atoms, cycloalkenyl with up to 7 carbon atoms, phenyl (optionally substituted), H2N-, R- NH-, (R) 2N-, aryl-NH-, alkoxy, when at the same time X is -CO-, and cycloalkoxy, when at the same time X is -CO-, with up to 6 carbon atoms, aryloxy, when at same time X is -CO-, thienyl, pyridyl, furyl or hydrogen, when at the same time X is -CO-, G hydrogen or R, with R having the meaning defined above, B a group of the formulas ** (See formula) ** R2, R3 and R4 hydrogen, halogen, R-, RO-, RS-, R-SO-, R-SO2-, nitro, hydroxy, (R) 2N-, R-CONH- or R-COO, where R has the meaning defined above, and whose penicillinic acids, in regarding the chirality center (see formula) can be presented in the two possible configurations R and S and as mixtures of the resulting diastereomers; characterized in that compounds of general formula II ** (See formula) ** in which B and (see formula) have the meanings indicated above, are reacted with compounds of general formula III A-Z-W III in which A has the meaning defined above and W represents halogen, azide or a group (see formula), in water within the pH range of 1 to 9 at a range temperature of approximately 0º to + 50ºC. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2318955A DE2318955C2 (en) | 1973-04-14 | 1973-04-14 | Process for the preparation of acylureidopenicillins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES425197A1 true ES425197A1 (en) | 1976-07-01 |
Family
ID=5878127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES425197A Expired ES425197A1 (en) | 1973-04-14 | 1974-04-10 | Penicillanic acids their production and their medicinal use |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS606956B2 (en) |
| AR (1) | AR200919A1 (en) |
| AT (1) | AT331973B (en) |
| BE (1) | BE813647A (en) |
| BG (1) | BG25095A3 (en) |
| CA (1) | CA1032159A (en) |
| CH (1) | CH592672A5 (en) |
| CS (1) | CS188919B2 (en) |
| DD (1) | DD111080A5 (en) |
| DE (1) | DE2318955C2 (en) |
| DK (1) | DK157684B (en) |
| EG (1) | EG11471A (en) |
| ES (1) | ES425197A1 (en) |
| FI (1) | FI63412C (en) |
| FR (1) | FR2225151B1 (en) |
| GB (1) | GB1465355A (en) |
| HU (1) | HU168589B (en) |
| IE (1) | IE39363B1 (en) |
| IL (1) | IL44605A (en) |
| LU (1) | LU69852A1 (en) |
| NL (1) | NL7405027A (en) |
| PL (1) | PL90407B1 (en) |
| RO (1) | RO67263A (en) |
| SE (1) | SE416052B (en) |
| SU (1) | SU568368A3 (en) |
| YU (1) | YU36030B (en) |
| ZA (1) | ZA742334B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101585845B (en) * | 2009-05-08 | 2011-06-22 | 浙江金华康恩贝生物制药有限公司 | Preparation process of Mezlocillin |
| CN111471057A (en) * | 2020-04-28 | 2020-07-31 | 江苏海宏制药有限公司 | Process for preparing mezlocillin sodium by solvent crystallization |
-
1973
- 1973-04-14 DE DE2318955A patent/DE2318955C2/en not_active Expired
-
1974
- 1974-03-29 FR FR7411451A patent/FR2225151B1/fr not_active Expired
- 1974-04-08 CS CS742519A patent/CS188919B2/en unknown
- 1974-04-08 HU HUBA3057A patent/HU168589B/hu not_active IP Right Cessation
- 1974-04-08 YU YU970/74A patent/YU36030B/en unknown
- 1974-04-09 RO RO7478361A patent/RO67263A/en unknown
- 1974-04-10 AR AR253239A patent/AR200919A1/en active
- 1974-04-10 SE SE7404889A patent/SE416052B/en not_active IP Right Cessation
- 1974-04-10 BG BG7400026358A patent/BG25095A3/en unknown
- 1974-04-10 ES ES425197A patent/ES425197A1/en not_active Expired
- 1974-04-10 FI FI1090/74A patent/FI63412C/en active
- 1974-04-10 JP JP49040042A patent/JPS606956B2/en not_active Expired
- 1974-04-11 CA CA197,469A patent/CA1032159A/en not_active Expired
- 1974-04-11 IL IL7444605A patent/IL44605A/en unknown
- 1974-04-11 CH CH510374A patent/CH592672A5/xx not_active IP Right Cessation
- 1974-04-11 NL NL7405027A patent/NL7405027A/xx not_active Application Discontinuation
- 1974-04-11 SU SU7402013854A patent/SU568368A3/en active
- 1974-04-11 IE IE777/74A patent/IE39363B1/en unknown
- 1974-04-11 GB GB1612374A patent/GB1465355A/en not_active Expired
- 1974-04-11 DD DD177841A patent/DD111080A5/xx unknown
- 1974-04-11 ZA ZA00742334A patent/ZA742334B/en unknown
- 1974-04-12 AT AT309774A patent/AT331973B/en not_active IP Right Cessation
- 1974-04-12 LU LU69852A patent/LU69852A1/xx unknown
- 1974-04-12 BE BE143137A patent/BE813647A/en unknown
- 1974-04-13 PL PL1974170376A patent/PL90407B1/pl unknown
- 1974-04-13 EG EG74114A patent/EG11471A/en active
-
1979
- 1979-10-17 DK DK437579A patent/DK157684B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR200919A1 (en) | 1974-12-27 |
| DK437579A (en) | 1979-10-17 |
| JPS606956B2 (en) | 1985-02-21 |
| DE2318955A1 (en) | 1974-10-24 |
| AU6784874A (en) | 1975-10-16 |
| ATA309774A (en) | 1975-12-15 |
| DD111080A5 (en) | 1975-01-20 |
| GB1465355A (en) | 1977-02-23 |
| IL44605A0 (en) | 1974-06-30 |
| DK157684B (en) | 1990-02-05 |
| CA1032159A (en) | 1978-05-30 |
| IE39363B1 (en) | 1978-09-27 |
| IE39363L (en) | 1974-10-14 |
| HU168589B (en) | 1976-06-28 |
| IL44605A (en) | 1977-06-30 |
| DE2318955C2 (en) | 1982-12-23 |
| BE813647A (en) | 1974-10-14 |
| FR2225151B1 (en) | 1978-02-03 |
| LU69852A1 (en) | 1974-11-21 |
| ZA742334B (en) | 1975-04-30 |
| CH592672A5 (en) | 1977-10-31 |
| NL7405027A (en) | 1974-10-16 |
| SE416052B (en) | 1980-11-24 |
| SU568368A3 (en) | 1977-08-05 |
| YU97074A (en) | 1981-04-30 |
| FI63412B (en) | 1983-02-28 |
| FI63412C (en) | 1983-06-10 |
| JPS49135990A (en) | 1974-12-27 |
| CS188919B2 (en) | 1979-03-30 |
| FR2225151A1 (en) | 1974-11-08 |
| AT331973B (en) | 1976-09-10 |
| PL90407B1 (en) | 1977-01-31 |
| BG25095A3 (en) | 1978-07-12 |
| EG11471A (en) | 1978-12-31 |
| YU36030B (en) | 1981-11-13 |
| RO67263A (en) | 1980-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19910114 |