GB1465355A - Penicillanic acids their production and their medicinal use - Google Patents
Penicillanic acids their production and their medicinal useInfo
- Publication number
- GB1465355A GB1465355A GB1612374A GB1612374A GB1465355A GB 1465355 A GB1465355 A GB 1465355A GB 1612374 A GB1612374 A GB 1612374A GB 1612374 A GB1612374 A GB 1612374A GB 1465355 A GB1465355 A GB 1465355A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- carbon atoms
- group
- formula
- acetamido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1465355 Heterocyclic amido-acetamido penicillanic acids BAYER AG 11 April 1974 [14 April 1973 6 Oct 1973] 16123/74 Heading C2C Novel compounds of the Formula (I) in which A is a group and X is an -SO 2 - or -CO- group; Y is a -CO-, -CS-, group (R being a straight-chain or branched alkyl radical with 1-5 carbon atoms); (G being a hydrogen atom or a straight or branched chain alkyl radical with 1-5 carbon atoms); R 1 is an alkyl radical with 1-6 carbon atoms, or an alkenyl radical with 1-6 carbon atoms, or a cycloalkyl or cycloalkenyl radical with 1-7 carbon atoms, or an optionally substituted phenyl radical, or an -NH 2 , -NHR, -NR 2 , or -NH Aryl radical, or an alkoxy* or cycloalkoxy* radical with 1-6 carbon atoms, or an aryloxy*, thienyl, pyridyl, furyl or hydrogen* radical (R being as defined above, and provided that R 1 can only have the meaning marked * when X is a -CO- group; B is a group of the formula [in which R 2 , R 3 and R 4 are identical or different radicals selected from hydrogen, halogen, R-, RO-, RS-, R.SO-, R.SO 2 -, nitro, hydroxyl, -NR 2 , -NH.CO.R or -O.CO.R groups (R being as defined above]; Z is a -CO- or -CS- group; and C* denotes a centre of chirality, which can be in either the R- or the S- configuration ; the said acetamido-penicillanic acids being either optically pure or a mixture of diastereomers resulting from C* are obtained by reacting a compound of the formula with A-Z-W (III) (in which W is halogen, azide or -N(NO)-C 1-6 alkyl) in water in the absence of an organic solvent, at a pH 1-9 and temperature 0-50 C., and adjusting the pH if necessary to a value in the range 1-5 to precipitate the desired acetamido-penicillanic acid. Pharmaceutical compositions having antibacterial activity comprise compounds of Formula I above in admixture with a solid or liquefied gaseous diluent, or in admixture with a liquid diluent other than a solvent of a molecular weight less than 200 except in the presence of a surface active agent. The compositions may be in forms for administration perorally, parenterally, rectally or locally. The active ingedient (I) may also be used in fodder for animals for promoting feed utilization and growth.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2318955A DE2318955C2 (en) | 1973-04-14 | 1973-04-14 | Process for the preparation of acylureidopenicillins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1465355A true GB1465355A (en) | 1977-02-23 |
Family
ID=5878127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1612374A Expired GB1465355A (en) | 1973-04-14 | 1974-04-11 | Penicillanic acids their production and their medicinal use |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS606956B2 (en) |
| AR (1) | AR200919A1 (en) |
| AT (1) | AT331973B (en) |
| BE (1) | BE813647A (en) |
| BG (1) | BG25095A3 (en) |
| CA (1) | CA1032159A (en) |
| CH (1) | CH592672A5 (en) |
| CS (1) | CS188919B2 (en) |
| DD (1) | DD111080A5 (en) |
| DE (1) | DE2318955C2 (en) |
| DK (1) | DK157684B (en) |
| EG (1) | EG11471A (en) |
| ES (1) | ES425197A1 (en) |
| FI (1) | FI63412C (en) |
| FR (1) | FR2225151B1 (en) |
| GB (1) | GB1465355A (en) |
| HU (1) | HU168589B (en) |
| IE (1) | IE39363B1 (en) |
| IL (1) | IL44605A (en) |
| LU (1) | LU69852A1 (en) |
| NL (1) | NL7405027A (en) |
| PL (1) | PL90407B1 (en) |
| RO (1) | RO67263A (en) |
| SE (1) | SE416052B (en) |
| SU (1) | SU568368A3 (en) |
| YU (1) | YU36030B (en) |
| ZA (1) | ZA742334B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101585845B (en) * | 2009-05-08 | 2011-06-22 | 浙江金华康恩贝生物制药有限公司 | Preparation process of Mezlocillin |
| CN111471057A (en) * | 2020-04-28 | 2020-07-31 | 江苏海宏制药有限公司 | Process for preparing mezlocillin sodium by solvent crystallization |
-
1973
- 1973-04-14 DE DE2318955A patent/DE2318955C2/en not_active Expired
-
1974
- 1974-03-29 FR FR7411451A patent/FR2225151B1/fr not_active Expired
- 1974-04-08 YU YU970/74A patent/YU36030B/en unknown
- 1974-04-08 CS CS742519A patent/CS188919B2/en unknown
- 1974-04-08 HU HUBA3057A patent/HU168589B/hu not_active IP Right Cessation
- 1974-04-09 RO RO7478361A patent/RO67263A/en unknown
- 1974-04-10 SE SE7404889A patent/SE416052B/en not_active IP Right Cessation
- 1974-04-10 JP JP49040042A patent/JPS606956B2/en not_active Expired
- 1974-04-10 ES ES425197A patent/ES425197A1/en not_active Expired
- 1974-04-10 FI FI1090/74A patent/FI63412C/en active
- 1974-04-10 BG BG7400026358A patent/BG25095A3/en unknown
- 1974-04-10 AR AR253239A patent/AR200919A1/en active
- 1974-04-11 CA CA197,469A patent/CA1032159A/en not_active Expired
- 1974-04-11 IE IE777/74A patent/IE39363B1/en unknown
- 1974-04-11 IL IL7444605A patent/IL44605A/en unknown
- 1974-04-11 DD DD177841A patent/DD111080A5/xx unknown
- 1974-04-11 CH CH510374A patent/CH592672A5/xx not_active IP Right Cessation
- 1974-04-11 SU SU7402013854A patent/SU568368A3/en active
- 1974-04-11 NL NL7405027A patent/NL7405027A/xx not_active Application Discontinuation
- 1974-04-11 ZA ZA00742334A patent/ZA742334B/en unknown
- 1974-04-11 GB GB1612374A patent/GB1465355A/en not_active Expired
- 1974-04-12 LU LU69852A patent/LU69852A1/xx unknown
- 1974-04-12 BE BE143137A patent/BE813647A/en unknown
- 1974-04-12 AT AT309774A patent/AT331973B/en not_active IP Right Cessation
- 1974-04-13 PL PL1974170376A patent/PL90407B1/pl unknown
- 1974-04-13 EG EG74114A patent/EG11471A/en active
-
1979
- 1979-10-17 DK DK437579A patent/DK157684B/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101585845B (en) * | 2009-05-08 | 2011-06-22 | 浙江金华康恩贝生物制药有限公司 | Preparation process of Mezlocillin |
| CN111471057A (en) * | 2020-04-28 | 2020-07-31 | 江苏海宏制药有限公司 | Process for preparing mezlocillin sodium by solvent crystallization |
Also Published As
| Publication number | Publication date |
|---|---|
| DK437579A (en) | 1979-10-17 |
| YU97074A (en) | 1981-04-30 |
| DE2318955C2 (en) | 1982-12-23 |
| ES425197A1 (en) | 1976-07-01 |
| IL44605A0 (en) | 1974-06-30 |
| AT331973B (en) | 1976-09-10 |
| IE39363B1 (en) | 1978-09-27 |
| JPS606956B2 (en) | 1985-02-21 |
| FI63412B (en) | 1983-02-28 |
| RO67263A (en) | 1980-03-15 |
| AU6784874A (en) | 1975-10-16 |
| CA1032159A (en) | 1978-05-30 |
| ZA742334B (en) | 1975-04-30 |
| ATA309774A (en) | 1975-12-15 |
| BG25095A3 (en) | 1978-07-12 |
| AR200919A1 (en) | 1974-12-27 |
| SE416052B (en) | 1980-11-24 |
| DD111080A5 (en) | 1975-01-20 |
| IL44605A (en) | 1977-06-30 |
| BE813647A (en) | 1974-10-14 |
| LU69852A1 (en) | 1974-11-21 |
| CH592672A5 (en) | 1977-10-31 |
| JPS49135990A (en) | 1974-12-27 |
| FI63412C (en) | 1983-06-10 |
| NL7405027A (en) | 1974-10-16 |
| IE39363L (en) | 1974-10-14 |
| FR2225151A1 (en) | 1974-11-08 |
| YU36030B (en) | 1981-11-13 |
| DE2318955A1 (en) | 1974-10-24 |
| HU168589B (en) | 1976-06-28 |
| SU568368A3 (en) | 1977-08-05 |
| PL90407B1 (en) | 1977-01-31 |
| EG11471A (en) | 1978-12-31 |
| CS188919B2 (en) | 1979-03-30 |
| FR2225151B1 (en) | 1978-02-03 |
| DK157684B (en) | 1990-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |