ZA727473B - New penicillins,their production and their medicinal use - Google Patents

New penicillins,their production and their medicinal use

Info

Publication number
ZA727473B
ZA727473B ZA727473A ZA727473A ZA727473B ZA 727473 B ZA727473 B ZA 727473B ZA 727473 A ZA727473 A ZA 727473A ZA 727473 A ZA727473 A ZA 727473A ZA 727473 B ZA727473 B ZA 727473B
Authority
ZA
South Africa
Prior art keywords
production
medicinal use
new penicillins
penicillins
new
Prior art date
Application number
ZA727473A
Inventor
K Metzger
H Koenig
W Schroeck
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA727473B publication Critical patent/ZA727473B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
ZA727473A 1971-10-23 1972-10-20 New penicillins,their production and their medicinal use ZA727473B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2152967A DE2152967C3 (en) 1971-10-23 1971-10-23 Acylureidopenicillins

Publications (1)

Publication Number Publication Date
ZA727473B true ZA727473B (en) 1973-07-25

Family

ID=5823251

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA727473A ZA727473B (en) 1971-10-23 1972-10-20 New penicillins,their production and their medicinal use

Country Status (31)

Country Link
JP (2) JPS55391B2 (en)
AR (1) AR195805A1 (en)
AT (1) AT320152B (en)
BE (1) BE790440A (en)
BG (2) BG21609A3 (en)
CA (1) CA1019323A (en)
CH (1) CH579089A5 (en)
CS (1) CS188883B2 (en)
CY (1) CY947A (en)
DD (1) DD106044B3 (en)
DE (1) DE2152967C3 (en)
DK (1) DK134992C (en)
EG (1) EG10826A (en)
ES (1) ES407851A1 (en)
FI (1) FI56839C (en)
FR (1) FR2157908B1 (en)
GB (1) GB1392849A (en)
HK (1) HK18578A (en)
HU (1) HU167986B (en)
IE (1) IE37123B1 (en)
IL (1) IL40628A (en)
KE (1) KE2824A (en)
LU (1) LU66332A1 (en)
NO (1) NO143909C (en)
PH (1) PH9893A (en)
PL (2) PL93574B1 (en)
RO (2) RO63066A (en)
SE (1) SE412236B (en)
SU (1) SU527139A3 (en)
YU (1) YU264072A (en)
ZA (1) ZA727473B (en)

Families Citing this family (37)

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NL175419C (en) * 1971-10-23 1984-11-01 Bayer Ag METHOD FOR PREPARING OR MANUFACTURING ANTIBIOTIC ACTIVE PHARMACEUTICAL PREPARATIONS AND METHOD FOR PREPARING ANTIBIOTIC ACTIVE ALPHA-SUBSTITUTED 6- (ALFA- (3-ACYLUREIDO) -PETYL-ACIDYL-ACIDYL-ACIDYL)
US3983105A (en) * 1971-10-23 1976-09-28 Bayer Aktiengesellschaft Penicillins
US3974141A (en) * 1971-10-23 1976-08-10 Bayer Aktiengesellschaft Penicillins
US3972870A (en) * 1971-10-23 1976-08-03 Bayer Aktiengesellschaft Penicillins
US3974142A (en) * 1971-10-23 1976-08-10 Bayer Aktiengesellschaft Penicillins
US3978056A (en) * 1971-10-23 1976-08-31 Bayer Aktiengesellschaft Penicillins
US3972869A (en) * 1971-10-23 1976-08-03 Bayer Aktiengesellschaft Penicillins
US4009272A (en) * 1971-10-23 1977-02-22 Bayer Aktiengesellschaft Penicillins
DE2258973A1 (en) * 1972-12-01 1974-06-06 Bayer Ag PENICILLIN, THE METHOD FOR MANUFACTURING IT AND THEIR USE AS A MEDICINAL PRODUCT
JPS587637B2 (en) * 1973-12-27 1983-02-10 住友化学工業株式会社 Shinkipenicillin no Seihou
DE2407715C2 (en) * 1974-02-18 1982-12-02 Bayer Ag, 5090 Leverkusen Cephalosporins, processes for their production, as well as pharmaceuticals
IL47168A (en) * 1974-05-09 1979-07-25 Toyama Chemical Co Ltd Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same
DE2525541C2 (en) * 1975-06-07 1984-01-12 Bayer Ag, 5090 Leverkusen β-lactam antibiotics, processes for their preparation and pharmaceuticals containing them
DE2810083A1 (en) 1978-03-08 1979-09-20 Bayer Ag BETA-LACTAM COMPOUNDS
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
EP1780213A1 (en) 2005-10-27 2007-05-02 3M Innovative Properties Company Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups
TWI417095B (en) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mglur2-receptors
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
CN101801930B (en) 2007-09-14 2013-01-30 奥梅-杨森制药有限公司 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
BRPI0817101A2 (en) 2007-09-14 2017-05-09 Addex Pharmaceuticals Sa 1,3-disubstituted 4- (aryl-x-phenyl) -1h-pyridin-2-ones
ATE496906T1 (en) 2007-09-14 2011-02-15 Ortho Mcneil Janssen Pharm 1',3'-DISUBSTITUTED 4-PHENYL-3,4,5,6-TETRAHYDRO-2H,1'H-Ä1,4'ÜBIPYRI INYL-2'-ONE
WO2009062676A2 (en) 2007-11-14 2009-05-22 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2344470B1 (en) 2008-09-02 2013-11-06 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
RU2517181C2 (en) 2008-10-16 2014-05-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Indole and benzomorpholine derivatives as modulator of metabotropic glutamate receptors
BRPI0921333A2 (en) 2008-11-28 2015-12-29 Addex Pharmaceuticals Sa indole and benzoxazine derivatives as metabotropic glutamate receptor modulators
KR101753826B1 (en) 2009-05-12 2017-07-04 얀센 파마슈티칼즈, 인코포레이티드 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
BRPI1010831A2 (en) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa 1,2,4-triazolo [4,3-a] pyridine derivatives and their as positive allosteric modulators of mglur2 receptors
AU2010257905B2 (en) * 2009-06-10 2016-11-10 Techfields Biochem Co., Ltd. High penetration compositions or prodrugs of antimicrobials and antimicrobial-related compounds
PT2649069E (en) 2010-11-08 2015-11-20 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2643320B1 (en) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JP5852666B2 (en) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
NZ722385A (en) 2014-01-21 2019-11-29 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
CN109999025A (en) 2014-01-21 2019-07-12 詹森药业有限公司 Positive allosteric modulator or the combination of normotopia agonist including metabotropic glutamate energy receptor subtype 2 and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1770620A1 (en) * 1968-06-12 1971-11-11 Bayer Ag New penicillins

Also Published As

Publication number Publication date
DE2152967B2 (en) 1981-02-19
HK18578A (en) 1978-04-14
FI56839C (en) 1980-04-10
HU167986B (en) 1976-02-28
IL40628A0 (en) 1972-12-29
JPS57843B2 (en) 1982-01-08
BG20813A3 (en) 1975-12-20
KE2824A (en) 1978-04-07
SE412236B (en) 1980-02-25
EG10826A (en) 1976-12-31
PL93574B1 (en) 1977-06-30
NO143909B (en) 1981-01-26
AU4806472A (en) 1974-04-26
GB1392849A (en) 1975-04-30
CH579089A5 (en) 1976-08-31
JPS55391B2 (en) 1980-01-08
SU527139A3 (en) 1976-08-30
DD106044B3 (en) 1990-07-18
DE2152967A1 (en) 1973-05-03
DK134992B (en) 1977-02-21
ES407851A1 (en) 1975-10-01
BE790440A (en) 1973-04-24
IL40628A (en) 1976-08-31
DE2152967C3 (en) 1981-11-19
LU66332A1 (en) 1973-01-23
IE37123L (en) 1973-04-23
CA1019323A (en) 1977-10-18
DD106044A5 (en) 1974-05-20
PL89056B1 (en) 1976-10-30
AR195805A1 (en) 1973-11-09
AT320152B (en) 1975-01-27
FR2157908B1 (en) 1976-03-19
BG21609A3 (en) 1976-07-20
RO60670A (en) 1976-10-15
NO143909C (en) 1981-05-06
YU264072A (en) 1982-06-18
FR2157908A1 (en) 1973-06-08
DK134992C (en) 1977-07-18
PH9893A (en) 1976-06-08
CS188883B2 (en) 1979-03-30
JPS4849910A (en) 1973-07-14
IE37123B1 (en) 1977-05-11
RO63066A (en) 1978-06-15
CY947A (en) 1978-06-23
FI56839B (en) 1979-12-31
JPS4849787A (en) 1973-07-13

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