NO143909B - ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PENICILLIN COMPOUNDS - Google Patents
ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PENICILLIN COMPOUNDS Download PDFInfo
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- NO143909B NO143909B NO723810A NO381072A NO143909B NO 143909 B NO143909 B NO 143909B NO 723810 A NO723810 A NO 723810A NO 381072 A NO381072 A NO 381072A NO 143909 B NO143909 B NO 143909B
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- 150000002960 penicillins Chemical class 0.000 title 1
- 238000006073 displacement reaction Methods 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 3
- 238000010276 construction Methods 0.000 description 2
- 239000012809 cooling fluid Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 239000004567 concrete Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011513 prestressed concrete Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Description
Bæregulv for stabel av vertikale faste moderatorlegemer i en kjernereaktor. Support floor for a stack of vertical solid moderator bodies in a nuclear reactor.
Oppfinnelsen gjelder et bærestell for The invention relates to a carrying frame for
moderatorstabelen i en kjernereaktor. the moderator stack in a nuclear reactor.
Det er kjent at den kombinerte virk-ning av temperaturstigning og av feno-mener som betegnes som «Wigner-effekt», It is known that the combined effect of temperature rise and of phenomena known as the "Wigner effect",
i atommiler fører til at moderatoren under-går lokale deformasjoner som kan skade in atomic miles causes the moderator to undergo local deformations that can cause damage
ikke alene det sammenhengende forløp av not only the continuous course of
de langsgående kanaler i midten av søylene, the longitudinal channels in the middle of the columns,
men også konstruksjonens stabilitet. Imidlertid er det mulig i det minste i stor ut-strekning å overvinne de nevnte vanskelig-heter, f. eks. ved å utføre stabelen med but also the stability of the construction. However, it is possible, at least to a large extent, to overcome the aforementioned difficulties, e.g. by executing the stack with
vertikale søyler som er anbragt ved siden vertical columns placed next to it
av hverandre og innbyrdes forbundet ved of each other and interconnected by
langsgående kiler som griper inn . i radiale longitudinal wedges that engage. in radial
spor i sideflatene av de på hinannen stå-ende prismatiske staver som utgjør søylene, grooves in the side faces of the stacked prismatic rods that make up the columns,
en utførelse som forøvrig er bekrevet og vist an embodiment which is otherwise described and shown
i fransk patentskrift nr. 1.214.246. in French Patent Document No. 1,214,246.
På denne måte tillates både en relativ In this way, both a relative is allowed
forskyvning av hver søyle i vertikal retning displacement of each column in the vertical direction
i forhold til dem som omgir den, og en in relation to those who surround it, and a
tverrekspansj on av moderatorstavene ved transverse expansion of the moderator rods by
at der er sørget for tilstrekkelige klaringer that sufficient clearances have been provided
i bunnen av sporene for forbindelseskilene. at the bottom of the slots for the connecting wedges.
Dette forutsetter imidlertid at stabelen hviler på en fullstendig plan bunn som be-varer sin horisontale stilling under reaktorens arbeide. Skjønt det til dette formål, However, this assumes that the stack rests on a completely flat bottom which maintains its horizontal position during the reactor's operation. Although for this purpose,
når reaktorens dimensjoner er forholdsvis when the dimensions of the reactor are proportional
beskjedne, er mulig å benytte hvelv som er modest, it is possible to use vaults that are
utført i ett stykke og avstivet ved hjelp av made in one piece and braced by means of
strevere i form av rør eller ribber, og som strivers in the form of tubes or ribs, and which
ved sin omkrets hviler på den kasse eller tette omslutning som omgir reaktoren, gjelder dette ikke lenger når den foreskrevne reaktoreffekt nødvendiggjør betydelig stør-re diameterdimensjoner for reaktoren, f. eks. av størrelsesordenen 20 meter. De fritt-bærende lengder blir i dette tilfelle så store at det ikke lenger blir mulig å holde seg in-nenfor de tilsiktede toleranser for struktu-rens horisontale avretting. at its circumference rests on the box or tight enclosure that surrounds the reactor, this no longer applies when the prescribed reactor power necessitates significantly larger diameter dimensions for the reactor, e.g. of the order of 20 metres. In this case, the free-supporting lengths become so large that it is no longer possible to stay within the intended tolerances for the horizontal alignment of the structure.
Den foreliggende oppfinnelse tar sikte på å avhjelpe disse ulemper ved hjelp av en enkel anordning som dessuten gjør det mulig å sikre en bedre fordeling av lasten av stabelen på reaktorens bunn. The present invention aims to remedy these disadvantages by means of a simple device which also makes it possible to ensure a better distribution of the load of the stack on the bottom of the reactor.
Oppfinnelsen består i første rekke i at man lar stabelen hvile på en rekke konsentriske ringformede stive kranser som er anbragt i nærheten av hverandre og hver bæres av stolper eller lignende som står på bunnen av reaktorkassen og er anbragt symmetrisk om stabelens akse i plan gjennom denne. The invention primarily consists in allowing the stack to rest on a series of concentric annular rigid rings which are placed close to each other and each is supported by posts or the like which stand on the bottom of the reactor box and are placed symmetrically about the axis of the stack in a plane through it.
Foruten denne prinsipielle anordning går oppfinnelsen ut på en del ytterligere trekk som vil bli omtalt nærmere, nemlig særlig de følgende: — De ringformede kranser er forbundet innbyrdes ved kiler anbragt i radiale spor slik at de tillater små relative forskyvninger eller deformasjoner av én krans i forhold til de nærmest-liggende. På de respektive kransers underside er denne forbindelse supplert med en myk In addition to this basic device, the invention involves a number of further features which will be discussed in more detail, namely the following: - The annular rings are connected to each other by wedges placed in radial grooves so that they allow small relative displacements or deformations of one ring in relation to to those closest to you. On the underside of the respective wreaths, this connection is supplemented by a soft
forbindelse av tetningsbelg-typen. Hver bærestolpe har ved den ende som vender mot kransen, en leddakse som er anbragt loddrett på planet gjennom stabelens og stolpens akse på en måte som sikrer sidestivhet av hver krans for connection of the sealing bellows type. Each bearing post has, at the end facing the wreath, a joint axis which is placed perpendicular to the plane through the axis of the pile and the post in a way that ensures lateral stiffness of each wreath for
seg. themselves.
Ved sin annen ende støtter stolpene seg på reaktorkassen ved varmeisolerende ledd for å unngå å overføre varme fra bæregulvet til kassen. Dessuten er de fortrinsvis anbragt rett under reaktorens kanaler. At their other end, the posts rest on the reactor box at heat-insulating joints to avoid transferring heat from the supporting floor to the box. Moreover, they are preferably located directly below the reactor's channels.
Oppfinnelsen vil imidlertid forstås bedre fra den følgende detaljerte beskri-velse i forbindelse med tegningen, som viser ikke-begrensende utførelses-eksempler. Fig. 1 er et vertikalt snitt som skjema-tisk viser den nedre del av en kjernereaktor hvor stabelen hviler på et bæregulv i henhold til oppfinelsen. Fig. 2 er et horisontalt snitt efter linjen II--II på fig. 1. Fig. 3 er et detalj riss som tydeligere an-skueliggjør overgangen mellom to symme-triske kranser i bæregulvet. Fig. 4 er et snitt efter linjen IV-IV på fig. 3. Fig. 5 er et horisontalt snitt som viser en annen utførelsesvariant av oppfinnelsen. Fig. 6 er et detalj riss i større målestokk, som anskueliggjør den svingbare lagring av en bærestolpe for den del av bæregulvet på fig. 1, og The invention will, however, be better understood from the following detailed description in connection with the drawing, which shows non-limiting examples of embodiment. Fig. 1 is a vertical section schematically showing the lower part of a nuclear reactor where the stack rests on a support floor according to the invention. Fig. 2 is a horizontal section along the line II--II in fig. 1. Fig. 3 is a detailed drawing which more clearly illustrates the transition between two symmetrical rings in the supporting floor. Fig. 4 is a section along the line IV-IV in fig. 3. Fig. 5 is a horizontal section showing another embodiment of the invention. Fig. 6 is a detailed drawing on a larger scale, which illustrates the pivotable storage of a support post for the part of the support floor in fig. 1, and
fig. 7 er et snitt efter linjen VII-VII på fig. 6. fig. 7 is a section along the line VII-VII in fig. 6.
På fig. 1 er vist den nedre del av en kjernereaktor med fast moderator. Stabelen består av grafittsøyler 1 anbragt vertikalt ved siden av hverandre. Hver søyle er dannet ved at prismatiske staver, f. eks. med regelmessig sekskanttverrsnitt, er stillet ovenpå hverandre. De langsgående sentrale kanaler som er uttatt i midten av stavene for å oppta patronene av spaltestoff, er følgelig fordelt i et regelmessig nett med trekantede masker. Forbindelsen mellom søylene er , som ovenfor nevnt, sikret ved hjelp av radiale og langsgående kiler. Dessuten holdes stabelen stivt ved omkretsen ved hjelp av et metallharnisk 2 med sirkel-formet kontur. Det hele befinner seg i en omslutning 3, i alminnelighet kalt kassen, som er tett overfor kjølefluidet som sirku-lerer i reaktoren. Omslutningen er forsynt med en innvendig varmeisolerende foring 4 og et utvendig hylster 5, f. eks. av betong, som sikrer beskyttelsen mot strålin-gene fra den aktive del av reaktorkjernen. Et tynt blikk 6 sikrer en myk og tett forbindelse mellom harnisket 2 og omslutningen 3. In fig. 1 shows the lower part of a nuclear reactor with a fixed moderator. The stack consists of graphite columns 1 placed vertically next to each other. Each column is formed by prismatic rods, e.g. with a regular hexagonal cross-section, are placed on top of each other. The longitudinal central channels which are taken out in the middle of the rods to receive the cartridges of splitting material are consequently distributed in a regular network of triangular meshes. The connection between the columns is, as mentioned above, secured by means of radial and longitudinal wedges. In addition, the stack is held rigidly at the circumference by means of a metal harness 2 with a circular contour. The whole is located in an enclosure 3, generally called the box, which is close to the cooling fluid that circulates in the reactor. The enclosure is provided with an internal heat-insulating lining 4 and an external casing 5, e.g. of concrete, which ensures protection against radiation from the active part of the reactor core. A thin sheet 6 ensures a soft and tight connection between the harness 2 and the enclosure 3.
I henhold til oppfinnelsen hviler moderatorstabelen på en understøttelse 7, sammensatt av en rekke konsentriske kranser 8, 9, 10 og 11, som er anbragt like ved hverandre, eventuelt med en liten radial klaring mellom på hinannen følgende kranser. Hver krans bæres av et antall stolper 12, som er anbragt fordelt rundt stabelens akse. An-tallet av disse stolper kan variere alt efter de respektive dimensjoner av de forskjellige kranser og den last de skal bære. Stolpene haar et svingeledd 13 nær den ende som er forbundet med de respektive kranser i bæregulvet, og understøttes ved sin annen ende stivt på bunnen 14 av den tette omslutning 3 via metallbukker 15. According to the invention, the moderator stack rests on a support 7, composed of a series of concentric rings 8, 9, 10 and 11, which are placed close to each other, possibly with a small radial clearance between successive rings. Each wreath is supported by a number of posts 12, which are placed distributed around the axis of the stack. The number of these posts can vary according to the respective dimensions of the different wreaths and the load they must carry. The posts have a swivel joint 13 near the end which is connected to the respective rings in the supporting floor, and are supported at their other end rigidly on the bottom 14 of the tight enclosure 3 via metal supports 15.
Fig. 2, som er et horisontalt snitt av reatoren på fig. 1, viser nærmere den spe-sielle form av kransene som bærer stabelen. På grunn av den regelmessige anordning av moderatorsøylene får kransene i sin tur en stort sett tilnærmelsesvis seks-kantet ytterkontur. Sekskantens sider er sagtakket for nøyaktig å følge konturen av de prismatiske staver. Kransene er forbundet innbyrdes ved en rekke kiler 16, fortrinsvis anbragt i hjørnene av sekskantene. Disse kiler griper inn i radielle spor i kransene for å tillate disse å undergå små forskyvninger i forhold til hverandre, men samtidig hindre enhver relativ vinkelfor-skyvning av på hinannen følgende kranser. Denne anordning gjør det således mulig å fordele lasten jevnt på hver krans for seg, idet bøyningsmomentet på hver av dem ikke forandrer seg uansett hvilke deforma-masjoner der kan opptre under reaktorens arbeide. Tetningen mellom to og to konsentriske kranser sikres av vinkelstykker Fig. 2, which is a horizontal section of the reactor of fig. 1, shows in more detail the special shape of the wreaths that carry the stack. Due to the regular arrangement of the moderator columns, the wreaths in turn get a mostly approximately hexagonal outer contour. The sides of the hexagon are serrated to precisely follow the contour of the prismatic rods. The wreaths are connected to each other by a series of wedges 16, preferably placed in the corners of the hexagons. These wedges engage radial grooves in the rims to allow them to undergo small displacements relative to each other, but at the same time prevent any relative angular displacement of successive rims. This device thus makes it possible to distribute the load evenly on each ring separately, as the bending moment on each of them does not change regardless of the deformations that may occur during the reactor's work. The seal between two concentric rings is ensured by angle pieces
17 (fig. 3 og 4), som tillater dem å slutte 17 (fig. 3 and 4), which allows them to stop
seg til hverandre efter en brukket linje. Til hvert av vinkelstykkene er der sveiset en tetningsbelg 18, som tillater relativ vertikal forskyvning forårsaket ved forskjellige varmeutvidelser, under unngåelse av lekkasje av kjølefluidum gjennom eventu-elle spillerom som måtte foreligge som følge" av kransenes montering. to each other along a broken line. A sealing bellows 18 is welded to each of the angle pieces, which allows relative vertical displacement caused by different heat expansions, while avoiding leakage of cooling fluid through any clearances that may exist as a result of the mounting of the flanges.
Fig. 5 viser en utførelsesvariant hvor maskene i nettet av moderatorsøylene ikke er trekantede, men kvadratiske. Bæregulvet for stabelen blir da utført i form av konsentriske kranser med polygonal kontur, Fig. 5 shows an embodiment where the meshes in the network of the moderator columns are not triangular, but square. The bearing floor for the stack is then made in the form of concentric rings with a polygonal contour,
f. eks. som vist ved 19, 20, 21 og 22. e.g. as shown at 19, 20, 21 and 22.
Overensstemmende med oppfinnelsen Consistent with the invention
bør den leddede ende 13 av stolpene 12 som should the articulated end 13 of the posts 12 which
bærer kransene, være utført slik at de sikrer at gulvet blir holdt sammen, men at carries the wreaths, be designed so that they ensure that the floor is held together, but that
forskjellige deler allikevel kan vides ut different parts can still be expanded
fritt. I dette øyemed er stolpenes ledd-akser rettet loddrett på de respektive plan freely. For this purpose, the joint axes of the posts are aligned vertically on the respective planes
som inneholder stabelens akse og aksen for which contains the axis of the stack and the axis of
vedkommende stolpe altså loddrett på den the post in question is therefore perpendicular to it
radius til kransen som går gjennom for-bindelsespunktet med stolpen (fig. 6). I det radius of the flange that passes through the connection point with the post (fig. 6). In that
særtilfelle at den tette omslutning 3 er er-stattet med en kasse av forspent betong, er special case that the tight enclosure 3 is replaced by a box of prestressed concrete, is
det nødvendig å varmeisolere denne for å it is necessary to thermally insulate this in order to
unngå at den blir utsatt for en for stor avoid it being exposed to a too large
temperaturstigning. Under reaktorens drift temperature rise. During reactor operation
hviler stolpene ved sin nedre ende på var-meisolerte ledd 23 i høyde med varmeisola-sjonen for å forhindre varmeoverføring fra the posts rest at their lower end on heat-insulated joints 23 at height with the heat insulation to prevent heat transfer from
bæregulvet til kassen (fig. 7). the supporting floor of the box (fig. 7).
Fortrinsvis blir stolpene anbragt rett The posts are preferably positioned straight
under kanalene for reaktorens sikringssta-ver eller også rett under en brenselkanal, under the channels for the reactor's safety rods or also directly under a fuel channel,
f. eks. 24. Isåfall blir de oventil utført rør-formt med en rekke radiale hull 25 for å e.g. 24. If so, they are made in the form of tubes above with a series of radial holes 25 in order to
tillate passasje av kjølefluidet for spaltestoff-patronene. allow passage of the coolant for the fissile cartridges.
Ved en annen utførelsesform vil man In another embodiment, one will
kunne erstatte de ovenfor beskrevne ledd-stolper med stive stolper som er forbundet could replace the joint posts described above with rigid posts that are connected
med reaktorkassen og bærer de konsentriske kranser via ruller hvis akser står with the reactor box and carries the concentric rings via rollers whose axes are vertical
loddrett på kranseradiene i horisontalpla-net for likeledes å sikre sidestivhet av bæregulv-konstruksj onen. perpendicular to the flange radii in the horizontal plane to also ensure lateral stiffness of the supporting floor construction.
Claims (7)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2152967A DE2152967C3 (en) | 1971-10-23 | 1971-10-23 | Acylureidopenicillins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO143909B true NO143909B (en) | 1981-01-26 |
| NO143909C NO143909C (en) | 1981-05-06 |
Family
ID=5823251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO723810A NO143909C (en) | 1971-10-23 | 1972-10-23 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PENICILLIN COMPOUNDS |
Country Status (31)
| Country | Link |
|---|---|
| JP (2) | JPS57843B2 (en) |
| AR (1) | AR195805A1 (en) |
| AT (1) | AT320152B (en) |
| BE (1) | BE790440A (en) |
| BG (2) | BG21609A3 (en) |
| CA (1) | CA1019323A (en) |
| CH (1) | CH579089A5 (en) |
| CS (1) | CS188883B2 (en) |
| CY (1) | CY947A (en) |
| DD (1) | DD106044B3 (en) |
| DE (1) | DE2152967C3 (en) |
| DK (1) | DK134992C (en) |
| EG (1) | EG10826A (en) |
| ES (1) | ES407851A1 (en) |
| FI (1) | FI56839C (en) |
| FR (1) | FR2157908B1 (en) |
| GB (1) | GB1392849A (en) |
| HK (1) | HK18578A (en) |
| HU (1) | HU167986B (en) |
| IE (1) | IE37123B1 (en) |
| IL (1) | IL40628A (en) |
| KE (1) | KE2824A (en) |
| LU (1) | LU66332A1 (en) |
| NO (1) | NO143909C (en) |
| PH (1) | PH9893A (en) |
| PL (2) | PL93574B1 (en) |
| RO (2) | RO60670A (en) |
| SE (1) | SE412236B (en) |
| SU (1) | SU527139A3 (en) |
| YU (1) | YU264072A (en) |
| ZA (1) | ZA727473B (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3983105A (en) * | 1971-10-23 | 1976-09-28 | Bayer Aktiengesellschaft | Penicillins |
| US4009272A (en) * | 1971-10-23 | 1977-02-22 | Bayer Aktiengesellschaft | Penicillins |
| US3972869A (en) * | 1971-10-23 | 1976-08-03 | Bayer Aktiengesellschaft | Penicillins |
| US3974142A (en) * | 1971-10-23 | 1976-08-10 | Bayer Aktiengesellschaft | Penicillins |
| US3974141A (en) * | 1971-10-23 | 1976-08-10 | Bayer Aktiengesellschaft | Penicillins |
| US3972870A (en) * | 1971-10-23 | 1976-08-03 | Bayer Aktiengesellschaft | Penicillins |
| US3978056A (en) * | 1971-10-23 | 1976-08-31 | Bayer Aktiengesellschaft | Penicillins |
| NL175419C (en) * | 1971-10-23 | 1984-11-01 | Bayer Ag | METHOD FOR PREPARING OR MANUFACTURING ANTIBIOTIC ACTIVE PHARMACEUTICAL PREPARATIONS AND METHOD FOR PREPARING ANTIBIOTIC ACTIVE ALPHA-SUBSTITUTED 6- (ALFA- (3-ACYLUREIDO) -PETYL-ACIDYL-ACIDYL-ACIDYL) |
| DE2258973A1 (en) * | 1972-12-01 | 1974-06-06 | Bayer Ag | PENICILLIN, THE METHOD FOR MANUFACTURING IT AND THEIR USE AS A MEDICINAL PRODUCT |
| JPS587637B2 (en) * | 1973-12-27 | 1983-02-10 | 住友化学工業株式会社 | Shinkipenicillin no Seihou |
| DE2407715C2 (en) * | 1974-02-18 | 1982-12-02 | Bayer Ag, 5090 Leverkusen | Cephalosporins, processes for their production, as well as pharmaceuticals |
| IL47168A (en) * | 1974-05-09 | 1979-07-25 | Toyama Chemical Co Ltd | Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same |
| DE2525541C2 (en) * | 1975-06-07 | 1984-01-12 | Bayer Ag, 5090 Leverkusen | β-lactam antibiotics, processes for their preparation and pharmaceuticals containing them |
| DE2810083A1 (en) | 1978-03-08 | 1979-09-20 | Bayer Ag | BETA-LACTAM COMPOUNDS |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| EP1780213A1 (en) * | 2005-10-27 | 2007-05-02 | 3M Innovative Properties Company | Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups |
| AR059898A1 (en) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| NZ584145A (en) | 2007-09-14 | 2012-03-30 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1,4'] bipyridinyl-2'-ones |
| EP2205565B1 (en) | 2007-09-14 | 2013-04-17 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones |
| EA019085B1 (en) | 2007-09-14 | 2014-01-30 | Янссен Фармасьютикалз, Инк. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
| MX2010005110A (en) | 2007-11-14 | 2010-09-09 | Ortho Mcneil Janssen Pharm | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors. |
| ES2439291T3 (en) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | 3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors |
| US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| MX2011005242A (en) | 2008-11-28 | 2011-09-06 | Ortho Mcneil Janssen Pharm | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors. |
| CA2760259C (en) | 2009-05-12 | 2018-05-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5916129B2 (en) * | 2009-06-10 | 2016-05-11 | テックフィールズ バイオケム カンパニー リミテッド | Highly permeable compositions or prodrugs of antimicrobial agents and antimicrobial-related compounds |
| ES2536433T3 (en) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| JP5852664B2 (en) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor |
| CN103298809B (en) | 2010-11-08 | 2016-08-31 | 杨森制药公司 | 1,2,4-triazol [4,3-a] pyridine derivate and the purposes of the positive allosteric modulators as MGLUR2 acceptor thereof |
| JO3368B1 (en) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| JO3367B1 (en) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| WO2015110435A1 (en) | 2014-01-21 | 2015-07-30 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| ME03518B (en) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1770620A1 (en) * | 1968-06-12 | 1971-11-11 | Bayer Ag | New penicillins |
-
0
- BE BE790440D patent/BE790440A/xx not_active IP Right Cessation
-
1971
- 1971-10-23 DE DE2152967A patent/DE2152967C3/en not_active Expired
-
1972
- 1972-10-12 SU SU1839113A patent/SU527139A3/en active
- 1972-10-17 RO RO197272544A patent/RO60670A/ro unknown
- 1972-10-17 RO RO197285500A patent/RO63066A/en unknown
- 1972-10-17 PH PH14018A patent/PH9893A/en unknown
- 1972-10-19 BG BG021665A patent/BG21609A3/en unknown
- 1972-10-19 BG BG024757A patent/BG20813A3/en unknown
- 1972-10-19 FI FI2897/72A patent/FI56839C/en active
- 1972-10-19 CS CS727048A patent/CS188883B2/en unknown
- 1972-10-19 HU HUBA2815A patent/HU167986B/hu not_active IP Right Cessation
- 1972-10-19 DD DD72166352A patent/DD106044B3/en unknown
- 1972-10-20 IE IE1422/72A patent/IE37123B1/en unknown
- 1972-10-20 AT AT901072A patent/AT320152B/en not_active IP Right Cessation
- 1972-10-20 CH CH1531272A patent/CH579089A5/xx not_active IP Right Cessation
- 1972-10-20 DK DK522172A patent/DK134992C/en active
- 1972-10-20 SE SE7213592A patent/SE412236B/en unknown
- 1972-10-20 LU LU66332A patent/LU66332A1/xx unknown
- 1972-10-20 IL IL7240628A patent/IL40628A/en unknown
- 1972-10-20 CA CA154,338A patent/CA1019323A/en not_active Expired
- 1972-10-20 ZA ZA727473A patent/ZA727473B/en unknown
- 1972-10-21 PL PL1972183057A patent/PL93574B1/pl unknown
- 1972-10-21 EG EG437/72A patent/EG10826A/en active
- 1972-10-21 JP JP10490272A patent/JPS57843B2/ja not_active Expired
- 1972-10-21 ES ES407851A patent/ES407851A1/en not_active Expired
- 1972-10-21 JP JP10490172A patent/JPS55391B2/ja not_active Expired
- 1972-10-21 PL PL1972158392A patent/PL89056B1/pl unknown
- 1972-10-23 FR FR7237482A patent/FR2157908B1/fr not_active Expired
- 1972-10-23 AR AR244770A patent/AR195805A1/en active
- 1972-10-23 GB GB4869972A patent/GB1392849A/en not_active Expired
- 1972-10-23 YU YU02640/72A patent/YU264072A/en unknown
- 1972-10-23 NO NO723810A patent/NO143909C/en unknown
- 1972-10-23 CY CY947A patent/CY947A/en unknown
-
1978
- 1978-03-14 KE KE2824A patent/KE2824A/en unknown
- 1978-04-04 HK HK185/78A patent/HK18578A/en unknown
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