ES402561A1 - Procedure for the obtaining of aminopyridacine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining aminopyridazine derivatives of the formula **(See formula)** where R1 is amino, R2 is hydrogen or methyl, A is a group - (CH2) n, where n is 0 or an integer from 1 to 7, or a group (see formula), where R5 is alkyl or alkenyl of 1 to 16 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, 1-adamantyl, or a group - (CH2) m-R6, where m is 0 or an integer from 1 to 4, and R6 is phenyl monosubstituted by fluorine, chlorine, bromine, alkyl or alkoxy of 1 to 4 carbon atoms, alkyl mercapto of 1 to 4 carbon atoms, or phenyl; phenyl substituted by two or three substituents of the chloro, alkyl or alkoxy group of 1 to 4 carbon atoms; diphenylmethyl, the phenyl rings of which may be monosubstituted by fluorine, chlorine, bromine, alkyl or alkoxy of 1 to 4 carbon atoms; or naphthyl, or a group -OR7, where R7 is alkyl or alkenyl of 1 to 4 carbon atoms, or phenyl, phenylalkyl or phenylalkenyl which may be monosubstituted in the phenyl ring by chlorine, alkyl or alkoxy of 1 to 4 atoms of carbon, and wherein the alkylene or alkenylene chain is from 1 to 4 carbon atoms, and each of R8 and R9 is hydrogen or alkyl of 1 to 4 carbon atoms; characterized in that a compound of formula IIa is reacted, **(See formula)** where R8, R9 and A have the meanings indicated above, and X is chlorine, bromine, mercapto, or a group -SR10, where R10 is benzyl or alkyl of 1 to 4 carbon atoms, with a compound of formula III, **(See formula)** where R2 has the meaning indicated above. (Machine-translation by Google Translate, not legally binding)