ES417638A1 - 2,4,5-trisubstituted oxazoles - Google Patents

2,4,5-trisubstituted oxazoles

Info

Publication number
ES417638A1
ES417638A1 ES417638A ES417638A ES417638A1 ES 417638 A1 ES417638 A1 ES 417638A1 ES 417638 A ES417638 A ES 417638A ES 417638 A ES417638 A ES 417638A ES 417638 A1 ES417638 A1 ES 417638A1
Authority
ES
Spain
Prior art keywords
lower alkyl
group
formula
see formula
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES417638A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of ES417638A1 publication Critical patent/ES417638A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/4211,3-Oxazoles, e.g. pemoline, trimethadione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing 2,4,5-trisubstituted oxazoles, of formulas: ** (See formula) ** where A is cyclohexyl, thienyl, or a radical ** (See formula) ** wherein R represents one or more substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, halogen-lower alkyl, lower alkoxy, nitro, cyano, amino, carbamyl, acetamino or carboxy; one of the radicals R1 and R2 represents a lower alkyl group and the other a group (see formula), where R3 is independently selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, cycloalkyl, aryl, aryl-lower alkyl, hydroxy-lower alkyl, acyloxyalkyl, hydroxy, amino, alkylideneamino, cycloalkylideneamino, aralkylideneamino, R4 is independently selected from hydrogen, lower alkyl, lower alkenyl, cycloalkyl, aryl, aryl-lower alkyl, hydroxy-lower alkyl, acyloxy-lower alkyl, or R3 and R4 taken together can also form, with the nitrogen atom, a 5-7 membered ring that may contain other heteroatoms selected from nitrogen, oxygen, and sulfur; characterized in that it comprises reacting a compound of the formula: ** (See formula) ** wherein A is defined as above, and one of the groups R5 or R6 is lower alkyl and the other is a group of the formula: ** (See formula) ** in which R7 can be a halogen atom or a lower alkoxy group, with an amine of the formula: ** (See formula) ** wherein R3 and R4 are defined as above. (Machine-translation by Google Translate, not legally binding)
ES417638A 1972-08-07 1973-08-07 2,4,5-trisubstituted oxazoles Expired ES417638A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2795872 1972-08-07

Publications (1)

Publication Number Publication Date
ES417638A1 true ES417638A1 (en) 1976-02-01

Family

ID=11222675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES417638A Expired ES417638A1 (en) 1972-08-07 1973-08-07 2,4,5-trisubstituted oxazoles

Country Status (23)

Country Link
JP (1) JPS5030619B2 (en)
KR (1) KR780000069B1 (en)
AR (1) AR200007A1 (en)
AT (1) AT322551B (en)
AU (1) AU477231B2 (en)
BE (1) BE794096A (en)
CH (1) CH544105A (en)
CS (1) CS177127B2 (en)
DD (1) DD106387A5 (en)
DE (1) DE2301030A1 (en)
ES (1) ES417638A1 (en)
FR (1) FR2195430B1 (en)
GB (1) GB1374345A (en)
HU (1) HU164781B (en)
IE (1) IE36941B1 (en)
IL (1) IL40904A (en)
LU (1) LU66643A1 (en)
NL (1) NL149797B (en)
NO (1) NO137550C (en)
RO (1) RO63442A (en)
SE (1) SE376236B (en)
SU (1) SU511003A3 (en)
ZA (1) ZA728259B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD112905A5 (en) * 1971-09-02 1975-05-12 Snam Progetti
US4110256A (en) * 1976-06-22 1978-08-29 Nippon Soken, Inc. Catalyst for reforming fuel and method for producing same
JPS59125900U (en) * 1983-02-10 1984-08-24 マルヤス機械株式会社 assembly line equipment
DE3425118A1 (en) * 1984-07-07 1986-01-16 Boehringer Mannheim Gmbh, 6800 Mannheim NEW REDOX INDICATORS
JPS6133499U (en) * 1984-07-30 1986-02-28 中西金属工業株式会社 Pallets for manufacturing electrical products
JP2829451B2 (en) * 1990-11-30 1998-11-25 大塚製薬株式会社 Active oxygen suppressant
GB0709031D0 (en) 2007-05-10 2007-06-20 Sareum Ltd Pharmaceutical compounds
US8946231B2 (en) 2009-03-23 2015-02-03 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
GB201202027D0 (en) 2012-02-06 2012-03-21 Sareum Ltd Pharmaceutical compounds
DK2634185T3 (en) 2012-03-02 2016-03-21 Sareum Ltd Tyk2 kinase inhibitors
GB201617871D0 (en) 2016-10-21 2016-12-07 Sareum Limited Pharmaceutical compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226548A (en) * 1967-06-14 1971-03-31 Wyeth John & Brother Ltd

Also Published As

Publication number Publication date
NL7300326A (en) 1974-02-11
DD106387A5 (en) 1974-06-12
LU66643A1 (en) 1973-02-14
KR780000069B1 (en) 1978-03-30
IE36941L (en) 1974-02-07
CS177127B2 (en) 1977-07-29
AT322551B (en) 1975-05-26
JPS4945067A (en) 1974-04-27
BE794096A (en) 1973-05-16
NO137550C (en) 1978-03-15
ZA728259B (en) 1973-07-25
GB1374345A (en) 1974-11-20
AR200007A1 (en) 1974-10-15
SE376236B (en) 1975-05-12
IL40904A0 (en) 1973-01-30
CH544105A (en) 1973-11-15
NL149797B (en) 1976-06-15
AU477231B2 (en) 1976-10-21
HU164781B (en) 1974-04-11
DE2301030A1 (en) 1974-02-28
AU5698273A (en) 1974-12-19
FR2195430A1 (en) 1974-03-08
IL40904A (en) 1975-12-31
IE36941B1 (en) 1977-03-30
JPS5030619B2 (en) 1975-10-02
RO63442A (en) 1978-07-15
NO137550B (en) 1977-12-05
FR2195430B1 (en) 1976-04-09
SU511003A3 (en) 1976-04-15

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