ES417638A1 - 2,4,5-trisubstituted oxazoles - Google Patents
2,4,5-trisubstituted oxazolesInfo
- Publication number
- ES417638A1 ES417638A1 ES417638A ES417638A ES417638A1 ES 417638 A1 ES417638 A1 ES 417638A1 ES 417638 A ES417638 A ES 417638A ES 417638 A ES417638 A ES 417638A ES 417638 A1 ES417638 A1 ES 417638A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- group
- formula
- see formula
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for preparing 2,4,5-trisubstituted oxazoles, of formulas: ** (See formula) ** where A is cyclohexyl, thienyl, or a radical ** (See formula) ** wherein R represents one or more substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, halogen-lower alkyl, lower alkoxy, nitro, cyano, amino, carbamyl, acetamino or carboxy; one of the radicals R1 and R2 represents a lower alkyl group and the other a group (see formula), where R3 is independently selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, cycloalkyl, aryl, aryl-lower alkyl, hydroxy-lower alkyl, acyloxyalkyl, hydroxy, amino, alkylideneamino, cycloalkylideneamino, aralkylideneamino, R4 is independently selected from hydrogen, lower alkyl, lower alkenyl, cycloalkyl, aryl, aryl-lower alkyl, hydroxy-lower alkyl, acyloxy-lower alkyl, or R3 and R4 taken together can also form, with the nitrogen atom, a 5-7 membered ring that may contain other heteroatoms selected from nitrogen, oxygen, and sulfur; characterized in that it comprises reacting a compound of the formula: ** (See formula) ** wherein A is defined as above, and one of the groups R5 or R6 is lower alkyl and the other is a group of the formula: ** (See formula) ** in which R7 can be a halogen atom or a lower alkoxy group, with an amine of the formula: ** (See formula) ** wherein R3 and R4 are defined as above. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2795872 | 1972-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES417638A1 true ES417638A1 (en) | 1976-02-01 |
Family
ID=11222675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES417638A Expired ES417638A1 (en) | 1972-08-07 | 1973-08-07 | 2,4,5-trisubstituted oxazoles |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5030619B2 (en) |
| KR (1) | KR780000069B1 (en) |
| AR (1) | AR200007A1 (en) |
| AT (1) | AT322551B (en) |
| AU (1) | AU477231B2 (en) |
| BE (1) | BE794096A (en) |
| CH (1) | CH544105A (en) |
| CS (1) | CS177127B2 (en) |
| DD (1) | DD106387A5 (en) |
| DE (1) | DE2301030A1 (en) |
| ES (1) | ES417638A1 (en) |
| FR (1) | FR2195430B1 (en) |
| GB (1) | GB1374345A (en) |
| HU (1) | HU164781B (en) |
| IE (1) | IE36941B1 (en) |
| IL (1) | IL40904A (en) |
| LU (1) | LU66643A1 (en) |
| NL (1) | NL149797B (en) |
| NO (1) | NO137550C (en) |
| RO (1) | RO63442A (en) |
| SE (1) | SE376236B (en) |
| SU (1) | SU511003A3 (en) |
| ZA (1) | ZA728259B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD112905A5 (en) * | 1971-09-02 | 1975-05-12 | Snam Progetti | |
| US4110256A (en) * | 1976-06-22 | 1978-08-29 | Nippon Soken, Inc. | Catalyst for reforming fuel and method for producing same |
| JPS59125900U (en) * | 1983-02-10 | 1984-08-24 | マルヤス機械株式会社 | assembly line equipment |
| DE3425118A1 (en) * | 1984-07-07 | 1986-01-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | NEW REDOX INDICATORS |
| JPS6133499U (en) * | 1984-07-30 | 1986-02-28 | 中西金属工業株式会社 | Pallets for manufacturing electrical products |
| JP2829451B2 (en) * | 1990-11-30 | 1998-11-25 | 大塚製薬株式会社 | Active oxygen suppressant |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| US8946231B2 (en) | 2009-03-23 | 2015-02-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| GB201202027D0 (en) | 2012-02-06 | 2012-03-21 | Sareum Ltd | Pharmaceutical compounds |
| DK2634185T3 (en) | 2012-03-02 | 2016-03-21 | Sareum Ltd | Tyk2 kinase inhibitors |
| GB201617871D0 (en) | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226548A (en) * | 1967-06-14 | 1971-03-31 | Wyeth John & Brother Ltd |
-
0
- BE BE794096D patent/BE794096A/en unknown
-
1972
- 1972-05-29 RO RO7200074945A patent/RO63442A/en unknown
- 1972-11-09 NO NO4068/72A patent/NO137550C/en unknown
- 1972-11-14 SE SE7214772A patent/SE376236B/xx unknown
- 1972-11-22 IL IL40904A patent/IL40904A/en unknown
- 1972-11-22 ZA ZA728259A patent/ZA728259B/en unknown
- 1972-11-27 CH CH1723972A patent/CH544105A/en not_active IP Right Cessation
- 1972-12-04 IE IE1677/72A patent/IE36941B1/en unknown
- 1972-12-13 LU LU66643A patent/LU66643A1/xx unknown
- 1972-12-14 GB GB5396672A patent/GB1374345A/en not_active Expired
- 1972-12-29 HU HULE673A patent/HU164781B/hu unknown
-
1973
- 1973-01-02 AT AT3673A patent/AT322551B/en not_active IP Right Cessation
- 1973-01-10 DE DE2301030A patent/DE2301030A1/en active Pending
- 1973-01-10 NL NL737300326A patent/NL149797B/en unknown
- 1973-01-18 AR AR246173A patent/AR200007A1/en active
- 1973-01-19 FR FR7301948A patent/FR2195430B1/fr not_active Expired
- 1973-01-25 JP JP48010642A patent/JPS5030619B2/ja not_active Expired
- 1973-04-16 CS CS2724A patent/CS177127B2/cs unknown
- 1973-06-15 AU AU56982/73A patent/AU477231B2/en not_active Expired
- 1973-07-20 DD DD172403A patent/DD106387A5/xx unknown
- 1973-08-06 SU SU1942243A patent/SU511003A3/en active
- 1973-08-07 KR KR7301283A patent/KR780000069B1/en active
- 1973-08-07 ES ES417638A patent/ES417638A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7300326A (en) | 1974-02-11 |
| DD106387A5 (en) | 1974-06-12 |
| LU66643A1 (en) | 1973-02-14 |
| KR780000069B1 (en) | 1978-03-30 |
| IE36941L (en) | 1974-02-07 |
| CS177127B2 (en) | 1977-07-29 |
| AT322551B (en) | 1975-05-26 |
| JPS4945067A (en) | 1974-04-27 |
| BE794096A (en) | 1973-05-16 |
| NO137550C (en) | 1978-03-15 |
| ZA728259B (en) | 1973-07-25 |
| GB1374345A (en) | 1974-11-20 |
| AR200007A1 (en) | 1974-10-15 |
| SE376236B (en) | 1975-05-12 |
| IL40904A0 (en) | 1973-01-30 |
| CH544105A (en) | 1973-11-15 |
| NL149797B (en) | 1976-06-15 |
| AU477231B2 (en) | 1976-10-21 |
| HU164781B (en) | 1974-04-11 |
| DE2301030A1 (en) | 1974-02-28 |
| AU5698273A (en) | 1974-12-19 |
| FR2195430A1 (en) | 1974-03-08 |
| IL40904A (en) | 1975-12-31 |
| IE36941B1 (en) | 1977-03-30 |
| JPS5030619B2 (en) | 1975-10-02 |
| RO63442A (en) | 1978-07-15 |
| NO137550B (en) | 1977-12-05 |
| FR2195430B1 (en) | 1976-04-09 |
| SU511003A3 (en) | 1976-04-15 |
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