ES421367A2 - Procedure for the obtaining of arilpiperazines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Improvements introduced in the object of the main patent number 410,618 filed on January 13, 1973 by procedure for obtaining arylpiperazines, of general formula I **(See formula)** wherein R1 signifies H or COR3, R2 signifies H or C 1-4 -alkyl, R3 signifies alkyl or aralkyl, optionally unsaturated, in each case with up to 10 carbon atoms, aryl, optionally substituted one or several times by alkyl, amino or methoxy groups, with a total of up to 10 carbon atoms, NH2, N (CH3) 2 or alkoxy with up to 4 carbon atoms, A means n represents 1-4, Z means (see formula) means phenyl, optionally substituted one or more times by alkyl and/or alkoxy groups, in each case nitro with 1-4 carbon atoms, trifluoromethyl and/or halogen, as well as its physiologically compatible acid addition salts according to main patent, characterized in that a compound of general formula II R2 - Q - A - Z where Q means -C (NH-NHCOR3) -CH-CO or -C0-CH-C (NH-NHC0R3) - and R2, R3, A and Z have the meaning indicated above, it cyclizes under water dissociation and because in If appropriate, the COR3 residue is cleaved from the product obtained by treatment with an agent with a solvolytic effect and/or the arylpiperazine of formula I obtained by treatment with an acid is transformed into a physiologically compatible acid addition salt and/or released from one of its acid addition salts by treatment with a base. (Machine-translation by Google Translate, not legally binding)