ES420898A1 - Procedure for the obtaining of pirazolic derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of pirazolic derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES420898A1 ES420898A1 ES420898A ES420898A ES420898A1 ES 420898 A1 ES420898 A1 ES 420898A1 ES 420898 A ES420898 A ES 420898A ES 420898 A ES420898 A ES 420898A ES 420898 A1 ES420898 A1 ES 420898A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- translation
- case
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for obtaining pyrazole derivatives of general formula **(See formula)** where R1 represents H, alkyl with 1-4 carbon atoms, Ar or COR3, R2 means H or alkyl with 1-4 carbon atoms, means alkyl, optionally unsaturated, or aralkyl, in each case with up to 10 carbon atoms. carbon, aryl, optionally substituted one or more times by alkyl, amino or methoxy groups, with a total of up to 10 carbon atoms, NH2, N (CH3) 2 or alkoxy with 1-4 carbon atoms, n represents 1 -6, Ar means phenyl, optionally substituted one or more times by alkyl and/or alkoxy groups, in each case with 1-4 carbon atoms, trifluoromethyl, NO2 and/or halogen and -E1-E2- means -CH2 -N-, -CH2-CH-, -CH-C- or -CH2-C (0H) -, the Ar groups may be the same or different from each other, as well as their physiologically compatible acid addition salts, characterized in that a pyrazoline or pyrazolidine derivative of general formula II where X means H, Cl, Br, I, OH, optionally esterified, alkylsulfonyl or arylsulfonyl, in each case with up to 10 carbon atoms, R1, R2, n, Ar and -E1 -E2 - have the meanings indicated in the formula I and the pyrazolidinic ring may contain a double bond, HX dissociates and because, if appropriate, the product obtained is transformed by treatment with an acid into a physiologically compatible acid addition salt and/or one of its addition salts acid is released by treatment with a base. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722258033 DE2258033A1 (en) | 1972-11-27 | 1972-11-27 | 3-Heterocyclylalkyl-pyrazoles prodn. - by dehydrogenation or acid elimination from pyrazol(id)ines, useful as CNS depressants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES420898A1 true ES420898A1 (en) | 1976-04-01 |
Family
ID=5862815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES420898A Expired ES420898A1 (en) | 1972-11-27 | 1973-11-27 | Procedure for the obtaining of pirazolic derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS4982669A (en) |
| DE (1) | DE2258033A1 (en) |
| ES (1) | ES420898A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3029160A1 (en) * | 1980-08-01 | 1982-03-04 | Basf Ag, 6700 Ludwigshafen | METHOD FOR PRODUCING PYRAZOLES |
| DE4425146A1 (en) * | 1994-07-15 | 1996-01-18 | Basf Ag | Use of heterocyclic compounds |
| DE19602505A1 (en) * | 1996-01-25 | 1997-07-31 | Merck Patent Gmbh | 1- (pyrazol-4-indol-3-yl) piperidines |
| DE10315569A1 (en) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituted pyrazole compounds |
| DE10315571A1 (en) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | pyrazole |
| KR100868353B1 (en) * | 2007-03-08 | 2008-11-12 | 한국화학연구원 | Piperazinyl-propyl-pyrazole derivatives as dopamine D4 receptor antagonists, and pharmaceutical compositions containing them |
-
1972
- 1972-11-27 DE DE19722258033 patent/DE2258033A1/en active Pending
-
1973
- 1973-11-19 JP JP12931173A patent/JPS4982669A/ja active Pending
- 1973-11-27 ES ES420898A patent/ES420898A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2258033A1 (en) | 1974-05-30 |
| JPS4982669A (en) | 1974-08-08 |
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