ES449425A1 - Aminopyrrole derivatives - Google Patents
Aminopyrrole derivativesInfo
- Publication number
- ES449425A1 ES449425A1 ES449425A ES449425A ES449425A1 ES 449425 A1 ES449425 A1 ES 449425A1 ES 449425 A ES449425 A ES 449425A ES 449425 A ES449425 A ES 449425A ES 449425 A1 ES449425 A1 ES 449425A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- carbalkoxy
- benzylidene
- aliphatic
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QLSWIGRIBOSFMV-UHFFFAOYSA-N 1h-pyrrol-2-amine Chemical class NC1=CC=CN1 QLSWIGRIBOSFMV-UHFFFAOYSA-N 0.000 title abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- -1 aliphatic aldehyde Chemical class 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
Abstract
Procedure for preparing aminopyrrole derivatives, of the following general formula: ** (See formula) ** and its pharmaceutically acceptable acid salts, wherein R1 represents phenyl or tolyl; Taken together R2 and R3 represent (C2-C4) alkylidene, benzylidene, or p-halogen-benzylidene; R4 represents (C2-C4) aliphatic acyl, benzoyl, (C1-C4) carbalkoxy and carboxyl; R5 is chosen from the group consisting of (C1-C4) alkyl and (C1-C4) carbalkoxy; characterized in that it comprises reacting a compound of formula II: ** (See formula) ** wherein R1, R4 and R5 have the same meanings as indicated above with an aliphatic aldehyde (C2-C4), an aliphatic ketone (C3-C4) benzaldehyde, or a p-halogenobenzaldehyde, in an organic solvent, such as alkanols for 3 -6 hours, at a temperature between room temperature and the reflux temperature of the reaction mixture. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3979073A GB1427945A (en) | 1973-08-22 | 1973-08-22 | Aminopyrrole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES449425A1 true ES449425A1 (en) | 1977-07-01 |
Family
ID=10411528
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES429446A Expired ES429446A1 (en) | 1973-08-22 | 1974-08-22 | Aminopyrrole derivatives |
| ES449426A Expired ES449426A1 (en) | 1973-08-22 | 1976-07-01 | Aminopyrrole derivatives |
| ES449425A Expired ES449425A1 (en) | 1973-08-22 | 1976-07-01 | Aminopyrrole derivatives |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES429446A Expired ES429446A1 (en) | 1973-08-22 | 1974-08-22 | Aminopyrrole derivatives |
| ES449426A Expired ES449426A1 (en) | 1973-08-22 | 1976-07-01 | Aminopyrrole derivatives |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5328914B2 (en) |
| AR (3) | AR210246A1 (en) |
| AT (1) | AT336600B (en) |
| BE (1) | BE819088A (en) |
| CA (1) | CA1050556A (en) |
| CH (1) | CH605741A5 (en) |
| CS (1) | CS188201B2 (en) |
| DD (1) | DD113756A5 (en) |
| DE (4) | DE2439284C2 (en) |
| DK (1) | DK156391C (en) |
| ES (3) | ES429446A1 (en) |
| FI (1) | FI61879C (en) |
| FR (1) | FR2241308B1 (en) |
| GB (1) | GB1427945A (en) |
| HU (1) | HU169728B (en) |
| IE (1) | IE40290B1 (en) |
| IL (1) | IL45368A (en) |
| IN (1) | IN140329B (en) |
| LU (1) | LU70764A1 (en) |
| NL (1) | NL7411092A (en) |
| NO (1) | NO143845C (en) |
| PL (2) | PL96806B1 (en) |
| RO (3) | RO70535A (en) |
| SE (1) | SE394429B (en) |
| SU (1) | SU843738A3 (en) |
| YU (1) | YU36926B (en) |
| ZA (1) | ZA744754B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1492663A (en) * | 1975-02-20 | 1977-11-23 | Lepetit Spa | 4-amino-3-pyrrole carboxamides |
| GB1548398A (en) * | 1975-06-05 | 1979-07-11 | Lilly Industries Ltd | Acylamino pyrroles furans and thiophenes |
| DE3212591A1 (en) * | 1982-04-03 | 1983-10-13 | Gödecke AG, 1000 Berlin | 2-PYRROLIN-3-CARBONITRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME |
| JPH0216740U (en) * | 1988-07-21 | 1990-02-02 | ||
| US5155152A (en) * | 1989-03-28 | 1992-10-13 | Ciba-Geigy Corporation | Substitute aminopyrroles as stabilizers for chlorine-containing polymers |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1148909A (en) * | 1965-04-19 | 1969-04-16 | Sumitomo Chemical Co | Process for production of novel phenylhydrazone and phenylhydrazine derivatives |
| GB1187903A (en) * | 1967-09-29 | 1970-04-15 | Sumitomo Chemical Co | Glucuronides of 3-Indolylaliphatic Acid Derivatives and Processes for Producing them |
-
1973
- 1973-08-22 GB GB3979073A patent/GB1427945A/en not_active Expired
-
1974
- 1974-07-27 ZA ZA00744754A patent/ZA744754B/en unknown
- 1974-07-29 IL IL45368A patent/IL45368A/en unknown
- 1974-08-01 YU YU2141/74A patent/YU36926B/en unknown
- 1974-08-08 NO NO742862A patent/NO143845C/en unknown
- 1974-08-08 IE IE1672/74A patent/IE40290B1/en unknown
- 1974-08-16 DD DD180545A patent/DD113756A5/xx unknown
- 1974-08-16 DE DE2439284A patent/DE2439284C2/en not_active Expired
- 1974-08-16 DE DE2462967A patent/DE2462967C2/en not_active Expired
- 1974-08-16 DE DE2462963A patent/DE2462963C2/en not_active Expired
- 1974-08-16 DE DE2462966A patent/DE2462966C2/en not_active Expired
- 1974-08-19 RO RO7491735A patent/RO70535A/en unknown
- 1974-08-19 RO RO79830A patent/RO72882B/en unknown
- 1974-08-19 RO RO7491734A patent/RO70534A/en unknown
- 1974-08-20 IN IN1864/CAL/1974A patent/IN140329B/en unknown
- 1974-08-20 NL NL7411092A patent/NL7411092A/en unknown
- 1974-08-20 LU LU70764A patent/LU70764A1/xx unknown
- 1974-08-21 CA CA207,472A patent/CA1050556A/en not_active Expired
- 1974-08-21 SE SE7410636A patent/SE394429B/en not_active IP Right Cessation
- 1974-08-21 HU HULE754A patent/HU169728B/hu not_active IP Right Cessation
- 1974-08-21 DK DK445974A patent/DK156391C/en active
- 1974-08-21 CH CH1142674A patent/CH605741A5/xx not_active IP Right Cessation
- 1974-08-21 JP JP9600974A patent/JPS5328914B2/ja not_active Expired
- 1974-08-21 FI FI2462/74A patent/FI61879C/en active
- 1974-08-21 SU SU742055571A patent/SU843738A3/en active
- 1974-08-22 PL PL1974189700A patent/PL96806B1/en unknown
- 1974-08-22 ES ES429446A patent/ES429446A1/en not_active Expired
- 1974-08-22 PL PL1974173617A patent/PL95235B1/pl unknown
- 1974-08-22 FR FR7428894A patent/FR2241308B1/fr not_active Expired
- 1974-08-22 CS CS745833A patent/CS188201B2/en unknown
- 1974-08-22 BE BE147818A patent/BE819088A/en not_active IP Right Cessation
- 1974-08-22 AT AT684774A patent/AT336600B/en not_active IP Right Cessation
- 1974-08-27 AR AR255253A patent/AR210246A1/en active
-
1976
- 1976-06-03 AR AR263503A patent/AR210133A1/en active
- 1976-06-03 AR AR263502A patent/AR210132A1/en active
- 1976-07-01 ES ES449426A patent/ES449426A1/en not_active Expired
- 1976-07-01 ES ES449425A patent/ES449425A1/en not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES449425A1 (en) | Aminopyrrole derivatives | |
| ES426303A1 (en) | Procedure for the obtaining of oxazolidine derivatives. (Machine-translation by Google Translate, not legally binding) | |
| SU505362A3 (en) | The method of producing oxypyrimidines | |
| SE7612685L (en) | PROCEDURE FOR PREPARING NEW IMIDAZOLE COMPOUNDS | |
| ES419739A1 (en) | 2-aryl-amino-imidazoline-2 compounds | |
| ES365102A1 (en) | A method for preparing pharmaceutical compositions based on new benzotriazinones. (Machine-translation by Google Translate, not legally binding) | |
| ES405646A1 (en) | Procedure for the preparation of new acids 4- (4 bifenilil) -4-hydroxy-butirrics, its esteres or lactonas. (Machine-translation by Google Translate, not legally binding) | |
| ES433132A1 (en) | Derivatives of 1-phenoxy-3-aminopropan-2-ol and processes for their preparation | |
| ES385774A1 (en) | Procedure for the preparation of new 2- (5-nitro-2- furil) -the (3,2-d) pyrimidines. (Machine-translation by Google Translate, not legally binding) | |
| ES448741A1 (en) | Procedure for the preparation of 6-aminopenicilanico or 7-aminodexacetoxicefalosporanico ácidos derivados. (Machine-translation by Google Translate, not legally binding) | |
| ES426948A1 (en) | Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding) | |
| KR880003919A (en) | Process for preparing 5-aralidene and alkylidene substituted hydantoin | |
| ES400792A1 (en) | Procedure for the preparation of new acids 4- (4-bifenilil) -butiricos and their steres. (Machine-translation by Google Translate, not legally binding) | |
| ES394894A1 (en) | Phenylacetohydroxamic acids process for their manufacture and preparations containing them | |
| ES417883A1 (en) | Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them | |
| ES432219A1 (en) | Phenylalkenoic acid derivatives | |
| GB1071124A (en) | Derivatives of pyrazolo-[4',5'-b]-11-oxo-18ª‡- and 18ª‰-olean-12-en-30-oic acid | |
| ES409552A1 (en) | Haloalkanesulphonic acid esters and their use in compositions for killing noxious organisms | |
| ES366533A1 (en) | 1,2-oxazinyl phenyl alkanoic acids | |
| ES364726A1 (en) | Procedure for the preparation of new derivatives of paminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding) | |
| GB1377886A (en) | 1,2,4-oxadiazole derivatives | |
| GB1340191A (en) | Synthesis of pyrazolo-triazoles | |
| ES414054A1 (en) | Furan derivatives | |
| ES407229A1 (en) | Procedure for the preparation of 5/6/acil-bencimidazolilcarbamatos of alcohil. (Machine-translation by Google Translate, not legally binding) | |
| ES384598A1 (en) | Procedure for the preparation of new basic pirrol derivatives. (Machine-translation by Google Translate, not legally binding) |