ES421228A1 - Procedure for the obtaining of pirazolic derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining pyrazole derivatives of general formula I **(See formula)** where R1 means alkyl with 1-4 carbon atoms, R2 means (see formula), R3 means H, alkyl with 1-4 carbon atoms or COR4, R4 means alkyl or aralkyl, optionally unsaturated, in each case with up to 10 carbon atoms, aryl, optionally substituted one or more times for alkyl with 1 to 4 carbon atoms, amino or methoxy, with up to 10 carbon atoms, -NH2, -N (CH3) 2 or alkoxy with 1-4 carbon atoms, Ar means phenyl, optionally substituted one or several times by alkyl with 1-4 carbon atoms, alkoxy with 1-4 carbon atoms, CF3, N02, NH2 or halogen, B and B2, in each case signify H or OH or together a further CC bond and n represents 1 to 4, as well as their physiologically compatible acid addition salts, characterized in that a compound of general formula IIa or IIb **(See formula)** wherein R1, R2 and n have the meaning above, or a mixture of such compounds is reacted with a compound of general formula III h2n-nhr3 III where R3 has the meaning indicated above, and/or, because an N-acyl group, if any, contained in the product obtained is removed by treatment with an agent of solvolitic or thermolytic effect and/or a compound of formula I is transformed by Treatment with an acid in a physiologically compatible acid addition salt and/or one of its salts is released by treatment with a base. (Machine-translation by Google Translate, not legally binding)