ES449161A1 - Terpnyl phen (oxy)elkyl amideines and their use in pharmaceutical compositions - Google Patents

Terpnyl phen (oxy)elkyl amideines and their use in pharmaceutical compositions

Info

Publication number
ES449161A1
ES449161A1 ES449161A ES449161A ES449161A1 ES 449161 A1 ES449161 A1 ES 449161A1 ES 449161 A ES449161 A ES 449161A ES 449161 A ES449161 A ES 449161A ES 449161 A1 ES449161 A1 ES 449161A1
Authority
ES
Spain
Prior art keywords
radical
formula
carbon atoms
hydrogen
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES449161A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAR PHA ETU EXPL MARQUES
Original Assignee
MAR PHA ETU EXPL MARQUES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAR PHA ETU EXPL MARQUES filed Critical MAR PHA ETU EXPL MARQUES
Publication of ES449161A1 publication Critical patent/ES449161A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of new amidines of formula: **(See formula)** where R is fixed in the ortho, mete or para position relative to Z and represents a terpenic radical, of exo or endo configuration, 2-isobornyl, 5-isocanyl or 2-norbornyl, R'and R''are the same or different and each represent a hydrogen or halogen atom, a straight or branched chain alkyl or alkoxy group of 1 to 4 carbon atoms, or a nitro or cyano group, Z is a single bond or an oxygen or sulfur, A is a straight chain or branched alkylene radical having 1 to 4 carbon atoms or the radical -CH2-CHOH-CH2-, R1 is a hydrogen atom, an alkyl group of 1 to 4 carbon atoms, hydroxyethyl or benzyl, R2 and R3 are hydrogen atoms or together represent a radical -CH2-CH3- or -CH2-CH2-CH2, thus forming with the radical (see formula) to which a Δ 2-imidazoline cycle is linked or 1,4,5,6-tetrahydropyrimidine, characterized in that it consists of reacting, in an alcoholic medium, a compound of the formula: **(See formula)** where R, R', R'', Z and A have the same meanings as in formula (I), with ammonia, ethylenediamine or 1,3-diamino-propane and eventually subjecting the compound obtained to an alkylation. (Machine-translation by Google Translate, not legally binding)
ES449161A 1975-06-23 1976-06-23 Terpnyl phen (oxy)elkyl amideines and their use in pharmaceutical compositions Expired ES449161A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2656375A GB1548875A (en) 1975-06-23 1975-06-23 Terpnyl phen (oxy)elkyl amideines and their use in pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ES449161A1 true ES449161A1 (en) 1977-12-01

Family

ID=10245609

Family Applications (2)

Application Number Title Priority Date Filing Date
ES449161A Expired ES449161A1 (en) 1975-06-23 1976-06-23 Terpnyl phen (oxy)elkyl amideines and their use in pharmaceutical compositions
ES461262A Expired ES461262A1 (en) 1975-06-23 1977-08-01 Terpnyl phen (oxy)elkyl amideines and their use in pharmaceutical compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES461262A Expired ES461262A1 (en) 1975-06-23 1977-08-01 Terpnyl phen (oxy)elkyl amideines and their use in pharmaceutical compositions

Country Status (5)

Country Link
BE (1) BE843255A (en)
CH (3) CH614932A5 (en)
ES (2) ES449161A1 (en)
FR (1) FR2315259A1 (en)
GB (1) GB1548875A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2469405A1 (en) * 1979-11-16 1981-05-22 Ugine Kuhlmann Systemic fungicidal salicylic acid ester(s) - 3,4,5,6-tetra:hydro:pyrimidin-2-yl-methyl and 2-imidazolin-2-yl methyl esters of 5-methyl 3-norbornyl-(2) salicylic acid
WO2009003868A2 (en) * 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
EP2501669B1 (en) 2009-11-19 2018-01-24 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Arylated camphenes, processes for their preparation and uses thereof
CN103250099B (en) 2010-09-28 2015-07-22 普罗米鲁斯有限责任公司 Norbornane-based PAC Ballast and positive-one photosensitive resin composition encompassing the PAC

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317514A (en) * 1970-11-30 1973-05-23 Erba Carlo Spa Imidazoline derivatives
GB1504862A (en) * 1974-04-11 1978-03-22 Mar Pha Etu Expl Marques Terpeno-phenoxyalkylamines

Also Published As

Publication number Publication date
BE843255A (en) 1976-12-22
FR2315259A1 (en) 1977-01-21
CH614941A5 (en) 1979-12-28
FR2315259B1 (en) 1978-12-08
CH614940A5 (en) 1979-12-28
CH614932A5 (en) 1979-12-28
ES461262A1 (en) 1978-05-01
GB1548875A (en) 1979-07-18

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