ES412050A1 - Procedure for preparation of benzodioxolo derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparation of benzodioxolo derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES412050A1 ES412050A1 ES412050A ES412050A ES412050A1 ES 412050 A1 ES412050 A1 ES 412050A1 ES 412050 A ES412050 A ES 412050A ES 412050 A ES412050 A ES 412050A ES 412050 A1 ES412050 A1 ES 412050A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- derivatives
- atoms
- alkyl
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Preparation procedure of the benzodioxole derivatives of general formula I: **(See formula)** in which: - n takes the values 0 or 1; - R1 and R2 each represent, simultaneously or alternatively, a hydrogen atom, an alkyl radical having 1 to 5 carbon atoms, an unsubstituted aryl radical or an aryl radical mono- or poly-substituted by a halogen atom, an alkyl or alkoxy radical each having 1 to 5 carbon atoms, or a trifluoromethyl radical, or R1 and R2 together representing a polymethylene- (CH2) m-radical in which m takes the values 4 or 5; - R3 represents a hydrogen atom or a methyl radical and - Het represents a heterocyclic radical that includes from 1 to 3 nitrogen atoms, possibly substituted by one or more halogen atoms, alkyl or alkoxy radicals each having from 1 to 5 carbon, hydroxy or amino atoms, as well as their salts of addition with suitable acids, characterized in that a mixture of an aldehyde of formula generates II: **(See formula)** in which n, R1 and R2 have the meanings defined above and of a substituted piperazine of general formula III: **(See formula)** in which R3, and Het have the meanings set forth above, to an alkylating reduction under a pressure of hydrogen <5 atmospheres in the presence of palladium carbon as catalyst, and in which the derivatives of general formula I thus obtained are optionally treated with the compatible acids to form the corresponding salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA151,973A CA979894A (en) | 1972-09-18 | 1972-09-18 | Procede de preparation de derives du benzodioxole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES412050A1 true ES412050A1 (en) | 1976-01-01 |
Family
ID=4094471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES412050A Expired ES412050A1 (en) | 1972-09-18 | 1973-02-24 | Procedure for preparation of benzodioxolo derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (10)
| Country | Link |
|---|---|
| CA (1) | CA979894A (en) |
| CS (1) | CS181234B2 (en) |
| DD (1) | DD104531A5 (en) |
| ES (1) | ES412050A1 (en) |
| HU (1) | HU166013B (en) |
| PL (1) | PL93980B1 (en) |
| RO (1) | RO71937A (en) |
| SE (1) | SE411044B (en) |
| SU (1) | SU468412A3 (en) |
| YU (1) | YU36724B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506354A (en) * | 1985-09-12 | 1996-04-09 | The Upjohn Company | Imidazolylpiperazinyl steroids |
| USRE35053E (en) * | 1985-09-12 | 1995-10-10 | The Upjohn Company | Amines useful in producing pharmaceutically active CNS compounds |
| US5099019A (en) * | 1985-09-12 | 1992-03-24 | Upjohn Company | Amines useful in producing pharmaceutically active CNS compounds |
| HU214331B (en) * | 1992-06-17 | 1998-03-02 | Gyógyszerkutató Intézet Kft. | Methods for producing piperazine and homopiperazine derivatives and pharmaceutical compositions containing them |
| US6150362A (en) * | 1997-12-12 | 2000-11-21 | Henkin; Jack | Triazine angiogenesis inhibitors |
-
1972
- 1972-09-18 CA CA151,973A patent/CA979894A/en not_active Expired
-
1973
- 1973-01-24 YU YU0189/73A patent/YU36724B/en unknown
- 1973-02-12 SU SU1879609A patent/SU468412A3/en active
- 1973-02-12 DD DD169166A patent/DD104531A5/xx unknown
- 1973-02-24 ES ES412050A patent/ES412050A1/en not_active Expired
- 1973-03-27 RO RO7374313A patent/RO71937A/en unknown
- 1973-03-30 CS CS7300002320A patent/CS181234B2/en unknown
- 1973-07-24 SE SE7310290A patent/SE411044B/en unknown
- 1973-08-02 PL PL1973164487A patent/PL93980B1/pl unknown
- 1973-09-18 HU HUSI1344A patent/HU166013B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RO71937A (en) | 1980-05-15 |
| PL93980B1 (en) | 1977-07-30 |
| YU36724B (en) | 1984-08-31 |
| SU468412A3 (en) | 1975-04-25 |
| DD104531A5 (en) | 1974-03-12 |
| CS181234B2 (en) | 1978-03-31 |
| HU166013B (en) | 1974-12-28 |
| SE411044B (en) | 1979-11-26 |
| CA979894A (en) | 1975-12-16 |
| YU18973A (en) | 1980-09-25 |
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