ES424483A1 - Hererocyclic derivatives of a guanidine - Google Patents

Hererocyclic derivatives of a guanidine

Info

Publication number
ES424483A1
ES424483A1 ES424483A ES424483A ES424483A1 ES 424483 A1 ES424483 A1 ES 424483A1 ES 424483 A ES424483 A ES 424483A ES 424483 A ES424483 A ES 424483A ES 424483 A1 ES424483 A1 ES 424483A1
Authority
ES
Spain
Prior art keywords
radical
carbon atoms
lower alcohol
straight
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424483A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES424483A1 publication Critical patent/ES424483A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/16—Nitrogen atoms not forming part of a nitro radical acylated on said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedure for the preparation of heterocyclic compounds substituted by a guanidinylidene radical of the general formula I **(See formula)** wherein R1 and R2 signify hydrogen atoms or straight or branched lower alcohol radicals with 1 to 4 carbon atoms and one of these radicals also signifies a hydroxyl group; R3 and R4 signify hydrogen atoms or straight or branched lower alcohol radicals with 1 to 4 carbon atoms; R5 signifies a hydrogen atom, a straight or branched lower alcohol radical with 1 to 6 carbon atoms, a hydroxyalkyl radical with 2 or 3 carbon atoms, a phenyl radical, optionally monosubstituted or substituted by lower alcohol or alkoxy radicals with 1 to 2 carbon atoms, by fluorine, chlorine or bromine atoms, or by nitrile groups, a benzyl or phenylethyl radical optionally monosubstituted or disubstituted by halogen atoms or the adamantyl radical; R6 signifies a hydrogen atom or a straight or branched chain lower alcohol radical with 1 to 4 carbon atoms; R7 signifies a hydrogen atom, a straight or branched lower alcohol radical with 1 to 6 carbon atoms, a hydroxyalkyl radical with 2 or 3 carbon atoms, a benzyl or phenethyl radical optionally substituted by halogen atoms, with alcohol radicals or lower alkoxy with 1 6 2 carbon atoms, a phenyl radical optionally substituted by chlorine atoms, carboxyl or aminosulfonyl groups, or an adamantyl radical; R8 means a hydrogen atom, a straight or branched chain lower alcohol radical with 1 to 4 carbon atoms or together with R7 and the nitrogen atom located between them mean a saturated 5- to 7-membered heterocyclic ring, which is eventually interrupted by an oxygen or sulfur atom or by another nitrogen atom, which may be substituted by a lower alcohol radical or a phenyl radical, and n denotes 0 or 1, as well as its acid addition salts physiologically compatible with organic or inorganic acids, characterized in that an S-alcoholylthiourea of the general formula II is reacted **(See formula)** wherein the radicals R1 through R5 are defined as indicated above and the radical R9 represents an alcoholic group, or its salts with organic or inorganic acids, with an amine of the general formula III (see formula) (Machine-translation by Google Translate, not legally binding)
ES424483A 1972-02-08 1974-03-21 Hererocyclic derivatives of a guanidine Expired ES424483A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2205744A DE2205744A1 (en) 1972-02-08 1972-02-08 Guanidinylidene-subst cpds

Publications (1)

Publication Number Publication Date
ES424483A1 true ES424483A1 (en) 1976-06-16

Family

ID=5835294

Family Applications (2)

Application Number Title Priority Date Filing Date
ES411341A Expired ES411341A1 (en) 1972-02-08 1973-02-06 Hererocyclic derivatives of a guanidine
ES424483A Expired ES424483A1 (en) 1972-02-08 1974-03-21 Hererocyclic derivatives of a guanidine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES411341A Expired ES411341A1 (en) 1972-02-08 1973-02-06 Hererocyclic derivatives of a guanidine

Country Status (9)

Country Link
JP (1) JPS4891068A (en)
AT (2) AT319268B (en)
AU (1) AU472170B2 (en)
BE (1) BE795112A (en)
DE (1) DE2205744A1 (en)
ES (2) ES411341A1 (en)
FR (1) FR2181714B1 (en)
GB (1) GB1409768A (en)
NL (1) NL7301701A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ183570A (en) * 1976-03-19 1979-06-08 Mcneilab Inc Heterocyclic guanidine derivatives, having anti-secretory and hypogliycaemic activity
US4211867A (en) 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
US4414211A (en) 1978-09-18 1983-11-08 Mcneilab, Inc. Heterocyclic derivatives of guanidine
US4266062A (en) 1978-09-18 1981-05-05 Mcneilab, Inc. (1-Methyl-2-pyridinylidene) derivatives of guanidine
US4182865A (en) * 1978-09-18 1980-01-08 Mcneil Laboratories, Inc. Diaza-cyclic derivatives of guanidine
CA1201119A (en) * 1978-09-18 1986-02-25 Mcneilab, Inc. Diaza-cyclic derivatives of guanidine
AU5263779A (en) * 1978-11-29 1980-05-29 Beecham Group Limited Derivatives of thiazolidin-2-ylidene and oxazolidin-2-ylidene with hypoglycaemic acitivity
DE3061396D1 (en) 1979-04-20 1983-01-27 Beecham Group Plc Oxazoline and thiazoline derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0020304A1 (en) * 1979-05-29 1980-12-10 Ciba-Geigy Ag Guanidines, process for their preparation, pharmaceutical preparations containing such compounds and their application
JPS55160764A (en) * 1979-05-29 1980-12-13 Ciba Geigy Ag Guanidine* its manufacture and pharmaceutic medicine containing same
EP0034002A3 (en) * 1980-01-22 1981-09-23 Beecham Group Plc Carboxamidine derivatives
DE102004008141A1 (en) 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidine compounds and their use as binding partners for 5-HT5 receptors
WO2018058109A1 (en) 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders

Also Published As

Publication number Publication date
BE795112A (en) 1973-08-07
AT324351B (en) 1975-08-25
AU5192873A (en) 1974-08-08
ES411341A1 (en) 1976-03-16
GB1409768A (en) 1975-10-15
FR2181714A1 (en) 1973-12-07
AU472170B2 (en) 1976-05-20
AT319268B (en) 1974-12-10
DE2205744A1 (en) 1973-08-09
NL7301701A (en) 1973-08-10
FR2181714B1 (en) 1977-07-01
JPS4891068A (en) 1973-11-27

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