ES354961A1 - A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES354961A1 ES354961A1 ES354961A ES354961A ES354961A1 ES 354961 A1 ES354961 A1 ES 354961A1 ES 354961 A ES354961 A ES 354961A ES 354961 A ES354961 A ES 354961A ES 354961 A1 ES354961 A1 ES 354961A1
- Authority
- ES
- Spain
- Prior art keywords
- radicals
- hal
- chlorine
- general formula
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of new amino ketones of the general formula I: **(See formula)** wherein the Hal radicals signify a chlorine or bromine atom; R1 signifies a hydrogen, chlorine or bromine atom; R2 and R3, which may be the same or different, signify hydrogen atoms, straight or branched chain alcohol radicals, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, dialkyl-aminoalcohyl, cycloalkyl, phenyl, benzyl or adamantyl or, together with the nitrogen atom, a pyrrolidino, piperidino, hexamethyleneimino, piperazino, morpholino or canfidino ring optionally substituted by lower alcohol radicals or by phenyl radicals; and that they may be the same or different, they mean hydrogen atoms, alcohol radicals with 1 to 3 carbon atoms or phenyl groups; and n means the numbers 0 or 1 or 2, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula II is reacted **(See formula)** in which the radicals Hal, R1, R4, R5 and the symbol n have the meanings indicated initially and Hal'represents a chlorine, bromine or iodine atom, with an amine of the general formula III: **(See formula)** in which the radicals R2 and R3 have the meanings indicated initially and, provided that the compounds obtained are in the form of their salts by addition of acid, they are transformed into their bases if desired and/or converted to the free bases according to usual methods in acid addition salts physiologically compatible with an organic or inorganic acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET0034103 | 1967-06-15 | ||
| DET0036083 | 1968-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES354961A1 true ES354961A1 (en) | 1969-11-16 |
Family
ID=26000342
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES355001A Expired ES355001A2 (en) | 1967-06-15 | 1968-06-14 | A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding) |
| ES355002A Expired ES355002A2 (en) | 1967-06-15 | 1968-06-14 | A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding) |
| ES355003A Expired ES355003A2 (en) | 1967-06-15 | 1968-06-14 | Procedure for the preparation of new amino-cetonas. (Machine-translation by Google Translate, not legally binding) |
| ES354961A Expired ES354961A1 (en) | 1967-06-15 | 1969-06-12 | A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES355001A Expired ES355001A2 (en) | 1967-06-15 | 1968-06-14 | A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding) |
| ES355002A Expired ES355002A2 (en) | 1967-06-15 | 1968-06-14 | A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding) |
| ES355003A Expired ES355003A2 (en) | 1967-06-15 | 1968-06-14 | Procedure for the preparation of new amino-cetonas. (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
| Country | Link |
|---|---|
| AT (2) | AT283321B (en) |
| DE (2) | DE1618010A1 (en) |
| ES (4) | ES355001A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2503705A1 (en) * | 1981-04-14 | 1982-10-15 | Synthelabo | PHENETHANOLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| DE3706585A1 (en) * | 1987-02-25 | 1988-09-08 | Schering Ag | ARYL- AND ARYLOXY-SUBSTITUTED TERT.-ALKYLENAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL USE |
-
1967
- 1967-06-15 DE DE19671618010 patent/DE1618010A1/en active Pending
-
1968
- 1968-03-15 DE DE19681668981 patent/DE1668981A1/en active Pending
- 1968-05-22 AT AT493568A patent/AT283321B/en not_active IP Right Cessation
- 1968-05-22 AT AT886268A patent/AT283324B/en not_active IP Right Cessation
- 1968-06-14 ES ES355001A patent/ES355001A2/en not_active Expired
- 1968-06-14 ES ES355002A patent/ES355002A2/en not_active Expired
- 1968-06-14 ES ES355003A patent/ES355003A2/en not_active Expired
-
1969
- 1969-06-12 ES ES354961A patent/ES354961A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT283324B (en) | 1970-08-10 |
| ES355001A2 (en) | 1970-04-16 |
| ES355003A2 (en) | 1970-12-01 |
| ES355002A2 (en) | 1970-04-16 |
| DE1618010A1 (en) | 1970-11-05 |
| AT283321B (en) | 1970-08-10 |
| DE1668981A1 (en) | 1971-07-08 |
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