ES454285A1 - 4-amino-trans-decahydroquinoline derivatives - Google Patents
4-amino-trans-decahydroquinoline derivativesInfo
- Publication number
- ES454285A1 ES454285A1 ES454285A ES454285A ES454285A1 ES 454285 A1 ES454285 A1 ES 454285A1 ES 454285 A ES454285 A ES 454285A ES 454285 A ES454285 A ES 454285A ES 454285 A1 ES454285 A1 ES 454285A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- general formula
- see formula
- furyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
Abstract
Procedure to prepare 4-amino-trans-decahydroquinoline derivatives, of general formula: **(See formula)** as well as its pharmaceutically acceptable acid addition salts, in which formula R1 represents a straight or branched chain alkyl or alkoxy group containing from 1 to 4 carbon atoms; a lower dialkylamino group such as dimethylamino; a saturated heterocyclic group such as pyrrolidino, piperidino or morfolino; an optionally substituted phenyl group; or an unsaturated heterocyclic group such as furyl or pyridyl; R2 represents a straight or branched chain alkyl group containing 1 to 4 carbon atoms; an optionally substituted phenyl group; a naphthyl group; an unsaturated heterocyclic group such as pyridyl, thienyl, methylthienyl, furyl, or pyrimidyl; an aralkyl group such as benzyl, phenethyl, cinnamyl, or phenylpropyl; or an alicyclic group such as cyclohexyl; and R3 represents a lower alkyl substituted furyl group, such as 2-methylfuryl; an aralkyl group such as benzyl, phenethyl, cinnamyl, or phenylpropyl; or a group represented by the general formula: **(See formula)** wherein A represents a straight or branched chain alkylene group; Y represents an oxygen or sulfur atom, a carbonyl, carbonylhydroxyimino, carbonylhydrazonc or sulfoxide group, or a group: **(See formula)** R4 and R5, which are the same or different, each represent hydrogen, a halogen atom, for example, fluorine, chlorine or bromine, or a methyl, methoxy or acetyl group n is 0 or an integer from 1 to 4, with the provided that when n is 0, Y represents a carbonyl group; characterized in that when R1 represents an optionally substituted alkyl, alkoxy or phenyl radical or an unsaturated heterocyclic group, a compound of the general formula is refluxed: **(See formula)** wherein R2 and R3 are defined as above, with a compound of the general formula: (see formula) (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB51507/75A GB1515540A (en) | 1975-12-16 | 1975-12-16 | 4-amino-trans-decahydroquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES454285A1 true ES454285A1 (en) | 1977-11-16 |
Family
ID=10460296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES454285A Expired ES454285A1 (en) | 1975-12-16 | 1976-12-16 | 4-amino-trans-decahydroquinoline derivatives |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS6022711B2 (en) |
| AR (1) | AR214988A1 (en) |
| AT (1) | AT357535B (en) |
| AU (1) | AU509897B2 (en) |
| BE (1) | BE849431A (en) |
| CA (1) | CA1077040A (en) |
| CH (1) | CH618970A5 (en) |
| DD (1) | DD128709A5 (en) |
| DE (1) | DE2656678C2 (en) |
| DK (1) | DK564876A (en) |
| ES (1) | ES454285A1 (en) |
| FI (1) | FI63023C (en) |
| FR (1) | FR2335224A1 (en) |
| GB (1) | GB1515540A (en) |
| HU (1) | HU175391B (en) |
| IE (1) | IE44355B1 (en) |
| IT (1) | IT1065969B (en) |
| MX (1) | MX5798E (en) |
| NL (1) | NL7613629A (en) |
| NO (1) | NO145916C (en) |
| NZ (1) | NZ182758A (en) |
| OA (1) | OA05515A (en) |
| PL (1) | PL101143B1 (en) |
| PT (1) | PT65970B (en) |
| SE (1) | SE434396B (en) |
| SU (1) | SU633476A3 (en) |
| YU (1) | YU39980B (en) |
| ZA (1) | ZA767112B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2592879B1 (en) * | 1986-01-13 | 1988-04-29 | Roussel Uclaf | NOVEL DECAHYDROQUINOLEIN DERIVATIVES, PROCESS FOR THEIR PREPARATION, PREPARATION INTERMEDIATES, THEIR APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM |
| PL1732933T3 (en) | 2004-03-26 | 2008-12-31 | Lilly Co Eli | Compounds for treating dyslipidemia |
-
1975
- 1975-12-16 GB GB51507/75A patent/GB1515540A/en not_active Expired
-
1976
- 1976-11-26 IE IE2613/76A patent/IE44355B1/en unknown
- 1976-11-29 ZA ZA00767112A patent/ZA767112B/en unknown
- 1976-11-29 NZ NZ182758A patent/NZ182758A/en unknown
- 1976-12-07 AU AU20328/76A patent/AU509897B2/en not_active Expired
- 1976-12-08 NL NL7613629A patent/NL7613629A/en not_active Application Discontinuation
- 1976-12-13 AR AR265813A patent/AR214988A1/en active
- 1976-12-13 CH CH1565976A patent/CH618970A5/en not_active IP Right Cessation
- 1976-12-13 CA CA267,706A patent/CA1077040A/en not_active Expired
- 1976-12-14 MX MX765223A patent/MX5798E/en unknown
- 1976-12-14 FR FR7637621A patent/FR2335224A1/en active Granted
- 1976-12-15 SU SU762428755A patent/SU633476A3/en active
- 1976-12-15 OA OA56017A patent/OA05515A/en unknown
- 1976-12-15 BE BE173281A patent/BE849431A/en not_active IP Right Cessation
- 1976-12-15 DE DE2656678A patent/DE2656678C2/en not_active Expired
- 1976-12-15 SE SE7614105A patent/SE434396B/en not_active IP Right Cessation
- 1976-12-15 NO NO764251A patent/NO145916C/en unknown
- 1976-12-15 IT IT30441/76A patent/IT1065969B/en active
- 1976-12-15 JP JP51151456A patent/JPS6022711B2/en not_active Expired
- 1976-12-15 DD DD7600196381A patent/DD128709A5/en unknown
- 1976-12-15 HU HU76LA900A patent/HU175391B/en unknown
- 1976-12-15 FI FI763603A patent/FI63023C/en not_active IP Right Cessation
- 1976-12-15 PT PT65970A patent/PT65970B/en unknown
- 1976-12-15 DK DK564876A patent/DK564876A/en not_active Application Discontinuation
- 1976-12-16 AT AT932076A patent/AT357535B/en not_active IP Right Cessation
- 1976-12-16 ES ES454285A patent/ES454285A1/en not_active Expired
- 1976-12-16 PL PL1976194452A patent/PL101143B1/en unknown
- 1976-12-16 YU YU3071/76A patent/YU39980B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK114783A (en) | UNKNOWN RELATIONSHIPS, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | |
| ES467288A1 (en) | N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidineacetamides | |
| DK34793A (en) | WATER SOLUBLE, PHARMACEUTICAL ACCEPTABLE SALT OF A MONOACYL DERIVATIVE OF RAPAMYCINE, PROCEDURE FOR ITS PREPARATION AND INJECTABLE, PHARMACEUTICAL PREPARATION CONTAINING IT | |
| ES403503A1 (en) | Procedure for the preparation of piperidine derivatives and their use as stabilizers (Machine-translation by Google Translate, not legally binding) | |
| ES417306A1 (en) | Piperidine stabilizers for polymers | |
| ES298057A1 (en) | Procedure for the preparation of new nitrogen bases (Machine-translation by Google Translate, not legally binding) | |
| ES456610A1 (en) | Therapeutic sulfonamides | |
| ES8604543A1 (en) | Piperazine derivatives with anticholinergic and/or antihistaminic activity | |
| ES467954A1 (en) | Indoles | |
| ES424483A1 (en) | Hererocyclic derivatives of a guanidine | |
| ES454285A1 (en) | 4-amino-trans-decahydroquinoline derivatives | |
| SE7604053L (en) | NEW 9-ALKYLAMINOERYTHROMYCIN ITS SALTS AND PROCEDURE FOR THE PREPARATION | |
| YU47010B (en) | 1,6-NAFTYRIDINE DERIVATIVES | |
| ES472276A1 (en) | Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them | |
| ES470783A1 (en) | Aminoalkoxybenzofurans | |
| CO4700285A1 (en) | DERIVATIVES OF 1-OXO-2- (FENILSULFONILAMINO) PENTILPIPERIDINA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS | |
| ES435351A1 (en) | 1-(3-phenylpropyl)-4-furoylpiperazine derivatives | |
| ES431765A1 (en) | Regenerated cellulose flameproofed by phosphorus-nitrogen heterocyclic compounds | |
| ES453121A1 (en) | Substituted aminoalkylaminopyridine compounds | |
| ES283569A1 (en) | Procedure for the obtaining of derivatives of 6-h-dibenzo [b, e] tiepine (Machine-translation by Google Translate, not legally binding) | |
| ES455539A1 (en) | A procedure for the preparation of new derivatives of piperidine. (Machine-translation by Google Translate, not legally binding) | |
| ES465366A2 (en) | 2-methoxybenzamides | |
| ES270019A1 (en) | Procedure for obtaining new compounds 2.3-dihydro of the series of the lysergic and dihydrolyseric acids (Machine-translation by Google Translate, not legally binding) | |
| ES422737A1 (en) | Procedure for the obtaining of heterociclic compounds based on piperazine or homopiperazine. (Machine-translation by Google Translate, not legally binding) | |
| ES389044A1 (en) | Procedure for the obtaining of derivatives of benzoci-cloheptatiofeno. (Machine-translation by Google Translate, not legally binding) |