NO145916B - ANALOGUE PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICAL ACTIVE 4-AMINO-TRANS-DECA HYDROKINOLINE DERIVATIVES - Google Patents
ANALOGUE PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICAL ACTIVE 4-AMINO-TRANS-DECA HYDROKINOLINE DERIVATIVES Download PDFInfo
- Publication number
- NO145916B NO145916B NO764251A NO764251A NO145916B NO 145916 B NO145916 B NO 145916B NO 764251 A NO764251 A NO 764251A NO 764251 A NO764251 A NO 764251A NO 145916 B NO145916 B NO 145916B
- Authority
- NO
- Norway
- Prior art keywords
- cover
- heat
- locking
- conducting body
- trans
- Prior art date
Links
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 238000010438 heat treatment Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims 2
- 230000008020 evaporation Effects 0.000 description 5
- 238000001704 evaporation Methods 0.000 description 5
- 239000003708 ampul Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Analogifreargangsmåte for fremstilling av farmakologisk aktive. 4-amino-trans-dekahydrokinolin-derivater.Analogous process for the preparation of pharmacologically active. 4-amino-trans-decahydroquinoline derivatives.
Description
Varmefordelingsmåler. Heat distribution meter.
Foreliggende oppfinnelse angår en; varmefordelingsmåler bestående av et var-meledende legeme innrettet til å festes til. et måleobjekt, f. eks. en radiator i et sentralvarmeanlegg eller en varmtvannsled-ning, et deksel avtagbart anbragt foran, det varmelédende legeme og et registrer-ingslegeme anbragt mellom dekslet og det varmelédende legeme, samt med samvir-kende låseorganer som er anbragt på det varmelédende legeme og dekslet, og som automatisk bringes i låseinngrep når dekslet settes på og deretter bare er tilgjenge-lig gjennom en åpning i dekslet som er dekket med et organ som kan gjennombry-tes. The present invention relates to a; heat distribution meter consisting of a heat-conducting body designed to be attached to. a measurement object, e.g. a radiator in a central heating system or a hot water line, a cover removable placed in front, the heat-conducting body and a registration body placed between the cover and the heat-conducting body, as well as with cooperating locking devices that are placed on the heat-conducting body and the cover, and which is automatically brought into locking engagement when the cover is put on and is then only accessible through an opening in the cover which is covered with a body that can be penetrated.
Det er kjent en varmefordelingsmåler av denne art, hvor låseorganene består av en bakovervendende fjærtunge på det varmelédende legeme og en fremovervendende nese på dekslet. Hvis dekslet trekkes fremover på denne måler, etter at låsemekanismen er kommet i inngrep, kan fjærtungen bøyes. Følgen er at låsemekanismen ikke i seg selv er egnet til å holde dekslet sikkert på plass. Videre er det ved påsettingen av dekslet ikke fullt tilstrekkelig garanti for, at låsemekanismen går i inngrep. Hvis fjærtungen er blitt deformert, slik at den ikke fjærer inn i nesen, vil måleren allike-vel kunne lukkes, og det vil derfor kunne forekomme, at måleravleseren ikke legger merke til at låsemekanismen ikke kommer i inngrep. A heat distribution meter of this kind is known, where the locking means consist of a backward-facing spring tongue on the heat-conducting body and a forward-facing nose on the cover. If the cover is pulled forward on this gauge, after the locking mechanism has engaged, the spring tongue can be bent. The consequence is that the locking mechanism is not in itself suitable for holding the cover securely in place. Furthermore, when the cover is put on, there is not a fully sufficient guarantee that the locking mechanism will engage. If the spring tongue has been deformed, so that it does not spring into the nose, the meter will still be able to be closed, and it will therefore be possible for the meter reader not to notice that the locking mechanism does not engage.
Oppfinnelsen går ut på å avhjelpe disse ulemper og det særegne består i at låse- The invention aims to remedy these disadvantages and the distinctive feature is that the locking
organene består av fjærende låsehaker som rager fremover fra det varmelédende legeme og som i låsestillingen er i inngrep med forsiden av en låseknast som ligger innvendig på dekslet umiddelbart på baksiden av åpningen i dekslet. the means consist of spring-loaded locking hooks which project forward from the heat-conducting body and which, in the locking position, engage with the front of a locking cam located inside the cover immediately behind the opening in the cover.
Ved denne konstruksjon strekker fjærorganene på det varmelédende legeme seg således fremover, og griper rundt en fremovervendende flate på dekslet, nærmere betegnet på dettes låseknast. Hvis det gjø-res forsøk på å fjerne dekslet utøves det derfor ikke noe trykk, men et trekk på fjærorganene. Fjærorganene kan ikke gi etter for dette trekk, således som det kan skje ved en trykkpåvirkning, som kan gi anledning til et bøyningsmoment, og det er derfor uten videre mulig, at låsemekanismen alene og uten spillerom kan. holde dekslet på plass. Det er heller ikke noen synnsynlighet for at fjærorganene skulle bli så sterkt deformert, at de ikke kommer i låseinngrep, uten at dette bemerkes, da det i så tilfelle er overveiende sannsynlig, at dekslet faller av, så snart det slippes. Endelig vil den omstendighet, at fjærorga-nenes låsehaker griper inn foran en fremovervendende flate på dekslet umiddelbart bak åpningen i dette, i høy grad lette håndteringen av fjærorganene med hen-blikk på å oppheve låsingen. Det kan f. eks. benyttes en spesialnøkkel, som stikkes gjennom den skive som kan gjennombry-tes og derved automatisk trenge inn mellom låsehakene og skyver disse til side. På denne måte skjer løsningen av dekslet fra lokket simpelthen ved, at en nøkkel stikkes inn gjennom skiven. With this construction, the spring means on the heat-conducting body thus extend forwards, and grip around a forward-facing surface on the cover, more specifically on its locking cam. If an attempt is made to remove the cover, no pressure is therefore exerted, but a pull on the spring members. The spring elements cannot yield to this pull, as can happen in the case of a pressure effect, which can give rise to a bending moment, and it is therefore without further ado that the locking mechanism alone and without leeway can. keep the cover in place. There is also no likelihood that the spring members would be so severely deformed that they would not engage in locking, without this being noted, as in that case it is overwhelmingly likely that the cover will fall off as soon as it is released. Finally, the fact that the locking hooks of the spring members engage in front of a forward-facing surface on the cover immediately behind the opening therein will greatly facilitate the handling of the spring members with a view to canceling the locking. It can e.g. a special key is used, which is inserted through the disc that can be broken through and thereby automatically penetrates between the locking hooks and pushes them aside. In this way, the cover is removed from the lid simply by inserting a key through the disc.
I henhold til oppfinnelsen blir således de manøvrer, som skal foretas både ved påsettingen av dekslet og ved avtagning av dette meget vesentlig forenklet, noe som er av stor betydning, da det som måleravle-sere ofte må anvendes personale uten noen faglig utdannelse. According to the invention, the maneuvers that must be carried out both when putting on the cover and when removing it are greatly simplified, which is of great importance, since personnel without any professional training often have to be used as meter readers.
På vedføyde tegning viser fig. 1 et snitt etter linjen I-l i fig. 2 og 3 gjennom en varmefordelingsmåler i en utførelses-form for oppfinnelsen. Fig. 2 viser et tverrsnitt gjennom sam-me måler, etter linjen II—II i fig. 1. Fig. 3 viser et tverrsnitt etter linjen III-III i fig. 1. The attached drawing shows fig. 1 a section along the line I-1 in fig. 2 and 3 through a heat distribution meter in an embodiment of the invention. Fig. 2 shows a cross-section through the same meter, along the line II—II in fig. 1. Fig. 3 shows a cross-section along the line III-III in fig. 1.
I det hus for varmefordelingsmåleren som er bestemt til å festes direkte på et varmelegeme, består husdelen 1 av en pa-rallepipedisk blikk av varmelédende material. På forsiden d.v.s. på den siden som vender mot målerens fordampningsbeholder 3 har blokken en fordypning 2 som ligger mellom loddrette ribber 20 og hvori fordampingsbeholderen 3 som er anbragt på målerens deksel 4 opptas, når dekslet settes på. I den viste utførelsesform består denne beholder av en sylindrisk glass-ampulle som er åpen oppover. In the housing for the heat distribution meter which is intended to be attached directly to a heating element, the housing part 1 consists of a parallelepiped sheet of heat-conducting material. On the front, i.e. on the side facing the meter's evaporation container 3, the block has a recess 2 which lies between vertical ribs 20 and in which the evaporation container 3 which is placed on the meter's cover 4 is accommodated, when the cover is put on. In the embodiment shown, this container consists of a cylindrical glass ampoule which is open upwards.
Dekslet 4 — forplaten — som er anbragt på forsiden av blokken har nederst en knast 6 hvor det er skrudd inn en skrue 7 med riflet hode 8. I oversiden av det riflete hode 8 finnes det en innadhvelvet fordypning hvor den nederste ende av fordamp-ningsbeholderen 3 hviler. The cover 4 — the front plate — which is placed on the front of the block has a knob 6 at the bottom where a screw 7 with a knurled head 8 is screwed in. In the upper side of the knurled head 8 there is a domed indentation where the lower end of the evaporation container 3 rests.
Foran beholderen 3 finnes det en ikke nærmere angitt avlesningsskala, som er anbragt på den side av en dekkplate 11 som vender mot beholderen 3 og som er satt inn i en åpning i dekslet og består av gjennom-siktig material og ikke kan tas av fra dekslet utenfra. In front of the container 3 there is a not specified reading scale, which is placed on the side of a cover plate 11 which faces the container 3 and which is inserted into an opening in the cover and consists of transparent material and cannot be removed from the cover from the outside.
Beholderen 3 er oventil understøttet ved hjelp av en skruefjær som er satt inn mellom den øvre ende av beholderen 3 og målerdekslets øverste endestykke 10. The container 3 is supported at the top by means of a coil spring which is inserted between the upper end of the container 3 and the upper end piece 10 of the meter cover.
På forsiden av dekslet er det i en åpning 15, fig. 3, i dekslet satt inn en dekkplate 16 som har fremspring 15, fig. 3 som rager til sidene slik at den ikke kan tas ut av den nevnte åpning i dekslet utenfra, men etter .sammensetningen av måleren holdesfast mellom dekslet 4 og ribbene 20. Den midterste del av den flate av dekk-skiven 11 som vender mot beholderen er hvelvet i: overensstemmelse med krum-ningsdiameteren av den del av beholder-omkretsen som vender mot denne skive og ligger, når dekslet 4 er anbragt på blokken 1, tett mot utsiden av beholderen 3. On the front of the cover there is an opening 15, fig. 3, a cover plate 16 which has projections 15 is inserted into the cover, fig. 3 which protrudes to the sides so that it cannot be removed from the aforementioned opening in the cover from the outside, but after the composition of the meter is held firmly between the cover 4 and the ribs 20. The middle part of the surface of the cover disk 11 which faces the container is the vault in: conformity with the curvature diameter of the part of the container circumference which faces this disk and lies, when the cover 4 is placed on the block 1, close to the outside of the container 3.
Dekslet 4 er låst fast til blokken 1 ved hjelp av en U-formet fjærbøyle 14 som er festet f. eks. fastklinket til den side av blokken 1 som vender mot dekslet. Når dekslet med innsatt fordampningsbeholder og avlesningsskala settes inn på blokken, griper bøylen 14 rundt knasten 6 som har en frittliggende forside 25, rundt hvilken endene av den U-formete bøyle 14 legger seg, når dekslet settes på, og derved hindrer at dekslet kan tas av sålenge det ikke er adgang til det område i det indre av dekslet hvor fjæren 14 finnes. The cover 4 is locked to the block 1 by means of a U-shaped spring bracket 14 which is attached, e.g. riveted to the side of block 1 facing the cover. When the cover with inserted evaporation container and reading scale is inserted on the block, the hoop 14 grips around the cam 6 which has a detached face 25, around which the ends of the U-shaped hoop 14 lie, when the cover is put on, thereby preventing the cover from being removed of as long as there is no access to the area in the interior of the cover where the spring 14 is found.
Foran dette område, som er lukket med dekkplaten 16 har denne plate et område 17, fig. 1 og 3, under beholderen 3 med så liten veggtykkelse at det, når beholderen eventuelt skal skiftes ut, eller det skal et-terfylles fordampningsvæske, lett kan knu-ses eller brekkes utenfra, hvoretter den åpning i dekkplaten 16 som derved dannes gir adgang til endene av fjæren 14 slik at disse ender kan bøyes fra hverandre, således at knasten 6 går fri av fjærendene og dekslet følgelig kan tas av. In front of this area, which is closed with the cover plate 16, this plate has an area 17, fig. 1 and 3, under the container 3 with such a small wall thickness that, when the container is possibly to be replaced, or evaporation liquid is to be refilled, it can easily be crushed or broken from the outside, after which the opening in the cover plate 16 that is thereby formed gives access to the ends of the spring 14 so that these ends can be bent apart, so that the cam 6 comes free of the spring ends and the cover can consequently be removed.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB51507/75A GB1515540A (en) | 1975-12-16 | 1975-12-16 | 4-amino-trans-decahydroquinoline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO764251L NO764251L (en) | 1977-06-17 |
| NO145916B true NO145916B (en) | 1982-03-15 |
| NO145916C NO145916C (en) | 1982-06-23 |
Family
ID=10460296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO764251A NO145916C (en) | 1975-12-16 | 1976-12-15 | ANALOGUE PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICAL ACTIVE 4-AMINO-TRANS-DECA HYDROKINOLINE DERIVATIVES |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS6022711B2 (en) |
| AR (1) | AR214988A1 (en) |
| AT (1) | AT357535B (en) |
| AU (1) | AU509897B2 (en) |
| BE (1) | BE849431A (en) |
| CA (1) | CA1077040A (en) |
| CH (1) | CH618970A5 (en) |
| DD (1) | DD128709A5 (en) |
| DE (1) | DE2656678C2 (en) |
| DK (1) | DK564876A (en) |
| ES (1) | ES454285A1 (en) |
| FI (1) | FI63023C (en) |
| FR (1) | FR2335224A1 (en) |
| GB (1) | GB1515540A (en) |
| HU (1) | HU175391B (en) |
| IE (1) | IE44355B1 (en) |
| IT (1) | IT1065969B (en) |
| MX (1) | MX5798E (en) |
| NL (1) | NL7613629A (en) |
| NO (1) | NO145916C (en) |
| NZ (1) | NZ182758A (en) |
| OA (1) | OA05515A (en) |
| PL (1) | PL101143B1 (en) |
| PT (1) | PT65970B (en) |
| SE (1) | SE434396B (en) |
| SU (1) | SU633476A3 (en) |
| YU (1) | YU39980B (en) |
| ZA (1) | ZA767112B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2592879B1 (en) * | 1986-01-13 | 1988-04-29 | Roussel Uclaf | NOVEL DECAHYDROQUINOLEIN DERIVATIVES, PROCESS FOR THEIR PREPARATION, PREPARATION INTERMEDIATES, THEIR APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM |
| WO2005097806A1 (en) * | 2004-03-26 | 2005-10-20 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
-
1975
- 1975-12-16 GB GB51507/75A patent/GB1515540A/en not_active Expired
-
1976
- 1976-11-26 IE IE2613/76A patent/IE44355B1/en unknown
- 1976-11-29 ZA ZA00767112A patent/ZA767112B/en unknown
- 1976-11-29 NZ NZ182758A patent/NZ182758A/en unknown
- 1976-12-07 AU AU20328/76A patent/AU509897B2/en not_active Expired
- 1976-12-08 NL NL7613629A patent/NL7613629A/en not_active Application Discontinuation
- 1976-12-13 CH CH1565976A patent/CH618970A5/en not_active IP Right Cessation
- 1976-12-13 AR AR265813A patent/AR214988A1/en active
- 1976-12-13 CA CA267,706A patent/CA1077040A/en not_active Expired
- 1976-12-14 FR FR7637621A patent/FR2335224A1/en active Granted
- 1976-12-14 MX MX765223A patent/MX5798E/en unknown
- 1976-12-15 NO NO764251A patent/NO145916C/en unknown
- 1976-12-15 SU SU762428755A patent/SU633476A3/en active
- 1976-12-15 JP JP51151456A patent/JPS6022711B2/en not_active Expired
- 1976-12-15 DD DD7600196381A patent/DD128709A5/en unknown
- 1976-12-15 OA OA56017A patent/OA05515A/en unknown
- 1976-12-15 SE SE7614105A patent/SE434396B/en not_active IP Right Cessation
- 1976-12-15 HU HU76LA900A patent/HU175391B/en unknown
- 1976-12-15 PT PT65970A patent/PT65970B/en unknown
- 1976-12-15 BE BE173281A patent/BE849431A/en not_active IP Right Cessation
- 1976-12-15 FI FI763603A patent/FI63023C/en not_active IP Right Cessation
- 1976-12-15 DK DK564876A patent/DK564876A/en not_active Application Discontinuation
- 1976-12-15 DE DE2656678A patent/DE2656678C2/en not_active Expired
- 1976-12-15 IT IT30441/76A patent/IT1065969B/en active
- 1976-12-16 AT AT932076A patent/AT357535B/en not_active IP Right Cessation
- 1976-12-16 YU YU3071/76A patent/YU39980B/en unknown
- 1976-12-16 ES ES454285A patent/ES454285A1/en not_active Expired
- 1976-12-16 PL PL1976194452A patent/PL101143B1/en unknown
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