SE7614105L - 4-AMINO-TRANSDEKAYDROKINOLINE DERIVATIVES - Google Patents
4-AMINO-TRANSDEKAYDROKINOLINE DERIVATIVESInfo
- Publication number
- SE7614105L SE7614105L SE7614105A SE7614105A SE7614105L SE 7614105 L SE7614105 L SE 7614105L SE 7614105 A SE7614105 A SE 7614105A SE 7614105 A SE7614105 A SE 7614105A SE 7614105 L SE7614105 L SE 7614105L
- Authority
- SE
- Sweden
- Prior art keywords
- group
- carbonyl
- alkyl
- reacting
- hydrazonomethylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
Abstract
1515540 4 - Amino - trans - decahydroquinoline derivatives LABAZ 24 Nov 1976 [16 Dec 1975] 51507/75 Heading C2C Novel trans decahydroquinoline derivatives of the Formula I and pharmaceutically acceptable acid addition salts thereof, wherein R<SP>1</SP> is alkyl, alkoxy, dialkylamino, a saturated heterocyclic ring attached through a ring nitrogen atom, an unsaturated heterocyclic group or an optionally substituted phenyl, R<SP>2</SP> is alkyl, optionally substituted phenyl, naphthyl, unsaturated heterocyclic optionally substituted by alkyl, aralkyl, aralkenyl or alicyclic and R<SP>3</SP> is alkyl substituted furyl, aralkyl, aralkenyl or a group where A is C 1-4 -alkylene, Y is oxygen, sulphur, carbonyl > C = NOH, >C = NNH 2 or sulphoxide or a group X R<SP>4</SP> and R<SP>5</SP> each are hydrogen, halogen, methyl, methoxy or acetyl and n is zero or 1, with the proviso that when n is zero, Y is carbonyl, where alkyl groups unless otherwise specified have 1 to 4 carbon atoms, may be prepared, when R 1 is other than dialkylamino or saturated heterocyclic group attached by a ring nitrogen atom and when R<SP>3</SP> is a group II, Y is other than hydroxyiminomethylene or hydrazonomethylene by reacting a compound III with R<SP>1</SP>COCl or (R<SP>1</SP>CO) 2 O or when R<SP>1</SP> is dialkylamino or a saturated heterocyclic group attached by a ring nitrogen atom, and when R<SP>3</SP> is a group II, Y is other than hydroxyiminomethylone or hydrazonomethylene by reacting a compound VI with an amine R<SP>1</SP>H, optionally followed by acid addition salt formation and/or reacting a carbonyl at Y with hydroxylamine or hydrazine to form a hydroxylimino methylene or a carbonyl hydrazonomethylene. Intermediates of the Formula III are prepared by reacting 4-oxo-trans-decahydroquinoline with an amine R<SP>2</SP>NH 2 and reducing the imine so formed to produce a compound VIII which is reacted with R<SP>3</SP>-Hal, where Hal is chlorine, bromine or iodine. When R<SP>3</SP> is a group II and Y is carbonyl, the carbonyl group is protected with a group X and thereafter optionally hydrolysed. The isomers of the compound VIII are separated. Pharmaceutical compositions of the compounds I with the usual excipients show analgesic activity when administered orally, parenterally or rectally. The compounds I in which R<SP>1</SP> is alkoxy also show antihypertensive action.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB51507/75A GB1515540A (en) | 1975-12-16 | 1975-12-16 | 4-amino-trans-decahydroquinoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7614105L true SE7614105L (en) | 1977-06-17 |
| SE434396B SE434396B (en) | 1984-07-23 |
Family
ID=10460296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7614105A SE434396B (en) | 1975-12-16 | 1976-12-15 | ANALOGY PROCEDURE FOR PREPARATION OF 4-AMINO-TRANSDEKAH HYDROKINOLINE DERIVATIVES |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS6022711B2 (en) |
| AR (1) | AR214988A1 (en) |
| AT (1) | AT357535B (en) |
| AU (1) | AU509897B2 (en) |
| BE (1) | BE849431A (en) |
| CA (1) | CA1077040A (en) |
| CH (1) | CH618970A5 (en) |
| DD (1) | DD128709A5 (en) |
| DE (1) | DE2656678C2 (en) |
| DK (1) | DK564876A (en) |
| ES (1) | ES454285A1 (en) |
| FI (1) | FI63023C (en) |
| FR (1) | FR2335224A1 (en) |
| GB (1) | GB1515540A (en) |
| HU (1) | HU175391B (en) |
| IE (1) | IE44355B1 (en) |
| IT (1) | IT1065969B (en) |
| MX (1) | MX5798E (en) |
| NL (1) | NL7613629A (en) |
| NO (1) | NO145916C (en) |
| NZ (1) | NZ182758A (en) |
| OA (1) | OA05515A (en) |
| PL (1) | PL101143B1 (en) |
| PT (1) | PT65970B (en) |
| SE (1) | SE434396B (en) |
| SU (1) | SU633476A3 (en) |
| YU (1) | YU39980B (en) |
| ZA (1) | ZA767112B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2592879B1 (en) * | 1986-01-13 | 1988-04-29 | Roussel Uclaf | NOVEL DECAHYDROQUINOLEIN DERIVATIVES, PROCESS FOR THEIR PREPARATION, PREPARATION INTERMEDIATES, THEIR APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM |
| DE602005014955D1 (en) | 2004-03-26 | 2009-07-30 | Lilly Co Eli | COMPOUNDS AND METHOD FOR THE TREATMENT OF DYSLIPIDEMIA |
-
1975
- 1975-12-16 GB GB51507/75A patent/GB1515540A/en not_active Expired
-
1976
- 1976-11-26 IE IE2613/76A patent/IE44355B1/en unknown
- 1976-11-29 ZA ZA00767112A patent/ZA767112B/en unknown
- 1976-11-29 NZ NZ182758A patent/NZ182758A/en unknown
- 1976-12-07 AU AU20328/76A patent/AU509897B2/en not_active Expired
- 1976-12-08 NL NL7613629A patent/NL7613629A/en not_active Application Discontinuation
- 1976-12-13 CA CA267,706A patent/CA1077040A/en not_active Expired
- 1976-12-13 CH CH1565976A patent/CH618970A5/en not_active IP Right Cessation
- 1976-12-13 AR AR265813A patent/AR214988A1/en active
- 1976-12-14 FR FR7637621A patent/FR2335224A1/en active Granted
- 1976-12-14 MX MX765223A patent/MX5798E/en unknown
- 1976-12-15 OA OA56017A patent/OA05515A/en unknown
- 1976-12-15 PT PT65970A patent/PT65970B/en unknown
- 1976-12-15 SU SU762428755A patent/SU633476A3/en active
- 1976-12-15 IT IT30441/76A patent/IT1065969B/en active
- 1976-12-15 DD DD7600196381A patent/DD128709A5/en unknown
- 1976-12-15 JP JP51151456A patent/JPS6022711B2/en not_active Expired
- 1976-12-15 DK DK564876A patent/DK564876A/en not_active Application Discontinuation
- 1976-12-15 DE DE2656678A patent/DE2656678C2/en not_active Expired
- 1976-12-15 SE SE7614105A patent/SE434396B/en not_active IP Right Cessation
- 1976-12-15 FI FI763603A patent/FI63023C/en not_active IP Right Cessation
- 1976-12-15 HU HU76LA900A patent/HU175391B/en unknown
- 1976-12-15 BE BE173281A patent/BE849431A/en not_active IP Right Cessation
- 1976-12-15 NO NO764251A patent/NO145916C/en unknown
- 1976-12-16 YU YU3071/76A patent/YU39980B/en unknown
- 1976-12-16 AT AT932076A patent/AT357535B/en not_active IP Right Cessation
- 1976-12-16 PL PL1976194452A patent/PL101143B1/en unknown
- 1976-12-16 ES ES454285A patent/ES454285A1/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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