ES465366A2 - 2-methoxybenzamides - Google Patents

2-methoxybenzamides

Info

Publication number
ES465366A2
ES465366A2 ES465366A ES465366A ES465366A2 ES 465366 A2 ES465366 A2 ES 465366A2 ES 465366 A ES465366 A ES 465366A ES 465366 A ES465366 A ES 465366A ES 465366 A2 ES465366 A2 ES 465366A2
Authority
ES
Spain
Prior art keywords
carbon atoms
radical
alcohol
atom
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465366A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7639033A external-priority patent/FR2375167A1/en
Priority claimed from FR7639034A external-priority patent/FR2378520A1/en
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES465366A2 publication Critical patent/ES465366A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Preparation procedure for methoxy-2-benzamide derivatives; according to which when said derivatives in the form of racemates or enantiomers correspond to formula (I) *** (see formula) *** In which R1 represents a chlorine atom or a radical SO2R5 in which R5 is an alcoholic having at 4 carbon atoms or a radical SO2NR6R7 in which R6 and R7 which are identical or different represent independently of each other a hydrogen atom or an alcohol radical of 1 to 4 carbon atoms; R2 represents a hydrogen atom or an alcohol of 1 to 4 carbon atoms; R3 and R4 independently of one another represent a halogen atom or a trifluoromethyltrotrifluoromethoxytrifluoromethylthioalkoxy radical of 1 to 4 carbon atoms or alcohol of 1 to 4 carbon atoms; and R5 represents a hydrogen or halogen atom or a trifluoromethyltrotrifluoromethoxytrifluoromethylthioalkoxy radical of 1 to 4 carbon atoms or alcohol of 1 to 4 carbon atoms; as well as its pharmaceutically acceptable acid addition salts. (Machine-translation by Google Translate, not legally binding)
ES465366A 1976-12-24 1977-12-23 2-methoxybenzamides Expired ES465366A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7639033A FR2375167A1 (en) 1976-12-24 1976-12-24 N-1-enzyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - esp. the 5-sulphamoyl-benzamide cpds., are psychotropics and neuroleptics
FR7639034A FR2378520A1 (en) 1976-12-24 1976-12-24 N-1-enzyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - esp. the 5-sulphamoyl-benzamide cpds., are psychotropics and neuroleptics

Publications (1)

Publication Number Publication Date
ES465366A2 true ES465366A2 (en) 1978-09-16

Family

ID=26219761

Family Applications (1)

Application Number Title Priority Date Filing Date
ES465366A Expired ES465366A2 (en) 1976-12-24 1977-12-23 2-methoxybenzamides

Country Status (14)

Country Link
JP (1) JPS5382771A (en)
AU (1) AU3192177A (en)
DE (1) DE2757406A1 (en)
DK (1) DK575877A (en)
ES (1) ES465366A2 (en)
FI (1) FI773911A (en)
GB (1) GB1556566A (en)
GR (1) GR66082B (en)
IL (1) IL53680A0 (en)
LU (1) LU78773A1 (en)
NL (1) NL7714301A (en)
NO (1) NO774402L (en)
NZ (1) NZ186075A (en)
SE (1) SE7714659L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3005722A1 (en) * 1980-02-15 1981-08-20 Bayer Ag, 5090 Leverkusen TRIFLUORMETHYLBENE CYL ESTER, METHOD FOR THE PRODUCTION THEREOF AND THE USE THEREOF IN PEST CONTROL
CA1157884A (en) * 1980-04-16 1983-11-29 Byron R. Cotter Process for the preparation of trifluoromethylbenzoyl halides

Also Published As

Publication number Publication date
GB1556566A (en) 1979-11-28
AU3192177A (en) 1979-06-28
NL7714301A (en) 1978-06-27
IL53680A0 (en) 1978-03-10
NO774402L (en) 1978-06-27
DE2757406A1 (en) 1978-06-29
NZ186075A (en) 1979-11-01
JPS5382771A (en) 1978-07-21
SE7714659L (en) 1978-06-25
GR66082B (en) 1981-01-15
DK575877A (en) 1978-06-25
LU78773A1 (en) 1979-07-20
FI773911A (en) 1978-06-25

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20170706