ES387016A1 - Un procedimiento para la preparacion de derivado de isoqui-nolina. - Google Patents
Un procedimiento para la preparacion de derivado de isoqui-nolina.Info
- Publication number
- ES387016A1 ES387016A1 ES387016A ES387016A ES387016A1 ES 387016 A1 ES387016 A1 ES 387016A1 ES 387016 A ES387016 A ES 387016A ES 387016 A ES387016 A ES 387016A ES 387016 A1 ES387016 A1 ES 387016A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- lower alkyl
- hydroxy
- general formula
- isoquinoline derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 methylenedioxy group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH10370A CH527194A (de) | 1970-01-06 | 1970-01-06 | Verfahren zur Herstellung von Isochinolin-Derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES387016A1 true ES387016A1 (es) | 1976-05-01 |
Family
ID=4179328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES387016A Expired ES387016A1 (es) | 1970-01-06 | 1971-01-05 | Un procedimiento para la preparacion de derivado de isoqui-nolina. |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5515476B1 (OSRAM) |
| AT (1) | AT303041B (OSRAM) |
| BE (1) | BE761219A (OSRAM) |
| CA (1) | CA999866A (OSRAM) |
| CH (2) | CH527194A (OSRAM) |
| DE (1) | DE2062001C2 (OSRAM) |
| DK (1) | DK125021B (OSRAM) |
| ES (1) | ES387016A1 (OSRAM) |
| FI (1) | FI49503C (OSRAM) |
| FR (1) | FR2081412B1 (OSRAM) |
| GB (1) | GB1335261A (OSRAM) |
| IE (1) | IE34859B1 (OSRAM) |
| IL (1) | IL35916A (OSRAM) |
| NL (1) | NL171444C (OSRAM) |
| NO (1) | NO135315C (OSRAM) |
| PH (1) | PH9682A (OSRAM) |
| SE (3) | SE368401B (OSRAM) |
| YU (1) | YU33660B (OSRAM) |
| ZA (1) | ZA708590B (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4719216A (en) * | 1983-06-23 | 1988-01-12 | Mcneilab, Inc. | Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants |
| US4595688A (en) * | 1983-06-23 | 1986-06-17 | Mcneilab, Inc. | Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof |
| ZA844402B (en) * | 1983-06-23 | 1986-01-29 | Mcneil Pharmaceutical | Hexahydropyrrolo(2,1-a)isoquinoline derivatives |
| GB2271566A (en) * | 1992-10-14 | 1994-04-20 | Merck & Co Inc | HIV integrase inhibitors |
| JP4907818B2 (ja) | 1999-11-03 | 2012-04-04 | エーエムアール テクノロジー インコーポレイテッド | アリールおよびヘテロアリール置換テトラヒドロイソキノリン、ならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを阻止するためのそれらの使用 |
| KR100878855B1 (ko) * | 1999-11-03 | 2009-01-15 | 에이엠알 테크놀로지, 인크. | 4-페닐-치환 테트라히드로이소퀴놀린, 및 노르에피네프린과 도파민과 세로토닌의 재흡수를 차단하기 위한 이의 용도 |
| US7163949B1 (en) * | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
| EP1113007A1 (en) | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
| MXPA03000275A (es) | 2000-07-11 | 2004-12-13 | Albany Molecular Res Inc | Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico. |
| ZA200701232B (en) | 2004-07-15 | 2008-08-27 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
| PT1899334E (pt) * | 2005-06-17 | 2008-11-06 | Janssen Pharmaceutica Nv | Compostos de naftiridina |
| MX2008000717A (es) | 2005-07-15 | 2008-03-18 | Amr Technology Inc | Tetrahidrobenzazepinas substituidas con arilo y heteroarilo y uso de las mismas para bloquear la reabsorcion de norepinefrina, dopamina, y serotonina. |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| AR071997A1 (es) | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
| JP2012526823A (ja) | 2009-05-12 | 2012-11-01 | アルバニー モレキュラー リサーチ， インコーポレイテッド | アリール、ヘテロアリール、および複素環置換テトラヒドロイソキノリンならびにそれらの使用 |
| AU2010247735B2 (en) | 2009-05-12 | 2015-07-16 | Albany Molecular Research, Inc. | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof |
| AU2010247763B2 (en) | 2009-05-12 | 2015-12-24 | Albany Molecular Research, Inc. | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670694B2 (de) * | 1966-05-05 | 1976-07-22 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von tetrahydroisochinolinen |
-
1970
- 1970-01-06 CH CH10370A patent/CH527194A/de not_active IP Right Cessation
- 1970-01-06 CH CH1011872A patent/CH538477A/de not_active IP Right Cessation
- 1970-12-16 DE DE2062001A patent/DE2062001C2/de not_active Expired
- 1970-12-16 SE SE17063/70A patent/SE368401B/xx unknown
- 1970-12-16 SE SE7313623A patent/SE386672B/xx unknown
- 1970-12-21 ZA ZA708590A patent/ZA708590B/xx unknown
- 1970-12-28 IL IL35916A patent/IL35916A/xx unknown
- 1970-12-29 NL NLAANVRAGE7018956,A patent/NL171444C/xx not_active IP Right Cessation
- 1970-12-31 FI FI703519A patent/FI49503C/fi active
-
1971
- 1971-01-04 IE IE6/71A patent/IE34859B1/xx unknown
- 1971-01-05 ES ES387016A patent/ES387016A1/es not_active Expired
- 1971-01-05 BE BE761219A patent/BE761219A/xx not_active IP Right Cessation
- 1971-01-05 FR FR7100097A patent/FR2081412B1/fr not_active Expired
- 1971-01-05 DK DK2571AA patent/DK125021B/da not_active IP Right Cessation
- 1971-01-05 GB GB45471A patent/GB1335261A/en not_active Expired
- 1971-01-05 NO NO7121A patent/NO135315C/no unknown
- 1971-01-05 AT AT4571A patent/AT303041B/de not_active IP Right Cessation
- 1971-01-06 YU YU19/71A patent/YU33660B/xx unknown
- 1971-01-06 JP JP7194A patent/JPS5515476B1/ja active Pending
- 1971-01-06 CA CA102,060A patent/CA999866A/en not_active Expired
- 1971-01-07 PH PH12087*UA patent/PH9682A/en unknown
-
1973
- 1973-10-05 SE SE7313622A patent/SE399879B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE386672B (sv) | 1976-08-16 |
| YU1971A (en) | 1977-06-30 |
| BE761219A (fr) | 1971-07-05 |
| NO135315B (OSRAM) | 1976-12-13 |
| SE368401B (OSRAM) | 1974-07-01 |
| FI49503B (OSRAM) | 1975-04-01 |
| FR2081412A1 (OSRAM) | 1971-12-03 |
| DE2062001C2 (de) | 1986-10-16 |
| NL171444B (nl) | 1982-11-01 |
| IE34859L (en) | 1971-07-06 |
| IL35916A (en) | 1973-11-28 |
| JPS5515476B1 (OSRAM) | 1980-04-23 |
| CH527194A (de) | 1972-08-31 |
| CA999866A (en) | 1976-11-16 |
| ZA708590B (en) | 1971-09-29 |
| PH9682A (en) | 1976-02-10 |
| SE399879B (sv) | 1978-03-06 |
| NO135315C (OSRAM) | 1977-03-23 |
| DE2062001A1 (de) | 1971-07-15 |
| AT303041B (de) | 1972-11-10 |
| NL7018956A (OSRAM) | 1971-07-08 |
| FI49503C (fi) | 1975-07-10 |
| CH538477A (de) | 1973-06-30 |
| GB1335261A (en) | 1973-10-24 |
| IL35916A0 (en) | 1971-02-25 |
| DK125021B (da) | 1972-12-18 |
| NL171444C (nl) | 1983-04-05 |
| YU33660B (en) | 1977-12-31 |
| IE34859B1 (en) | 1975-09-03 |
| FR2081412B1 (OSRAM) | 1974-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19880205 |