ES3075652T3 - Synthesis of substantially diastereomerically pure phosphate protides - Google Patents

Synthesis of substantially diastereomerically pure phosphate protides

Info

Publication number
ES3075652T3
ES3075652T3 ES18735380T ES18735380T ES3075652T3 ES 3075652 T3 ES3075652 T3 ES 3075652T3 ES 18735380 T ES18735380 T ES 18735380T ES 18735380 T ES18735380 T ES 18735380T ES 3075652 T3 ES3075652 T3 ES 3075652T3
Authority
ES
Spain
Prior art keywords
protides
synthesis
diastereomerically pure
substantially diastereomerically
pure phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES18735380T
Other languages
English (en)
Inventor
Hugh Griffith
Gordon Kennovin
Venkata Lakshmi Narasimha Rao Dammalapati
Mani Bushan Kotala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nucana PLC
Original Assignee
Nucana PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nucana PLC filed Critical Nucana PLC
Application granted granted Critical
Publication of ES3075652T3 publication Critical patent/ES3075652T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES18735380T 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides Active ES3075652T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives
PCT/GB2018/051638 WO2018229493A2 (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives

Publications (1)

Publication Number Publication Date
ES3075652T3 true ES3075652T3 (en) 2026-08-06

Family

ID=59358400

Family Applications (1)

Application Number Title Priority Date Filing Date
ES18735380T Active ES3075652T3 (en) 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides

Country Status (21)

Country Link
US (4) US11897913B2 (es)
EP (3) EP3638684B1 (es)
JP (5) JP7248209B2 (es)
KR (2) KR102695300B1 (es)
CN (3) CN117486959A (es)
AU (3) AU2018284131B2 (es)
BR (1) BR112019026747A2 (es)
CA (2) CA3065682A1 (es)
CL (1) CL2019003632A1 (es)
EA (1) EA201992873A1 (es)
ES (1) ES3075652T3 (es)
GB (1) GB201709471D0 (es)
IL (3) IL302559B2 (es)
MA (1) MA49379A (es)
MX (3) MX390901B (es)
NZ (2) NZ759692A (es)
PH (1) PH12019502825A1 (es)
SA (1) SA519410795B1 (es)
SG (1) SG11201911543UA (es)
WO (2) WO2018229493A2 (es)
ZA (1) ZA201908054B (es)

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GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
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GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
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CN120584123A (zh) 2022-12-07 2025-09-02 努卡那有限公司 核苷衍生物nuc-3373的合成

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Also Published As

Publication number Publication date
IL271159B2 (en) 2023-10-01
US20200181186A1 (en) 2020-06-11
SG11201911543UA (en) 2020-01-30
US11414452B2 (en) 2022-08-16
MX391332B (es) 2025-03-21
IL302559B2 (en) 2024-09-01
WO2018229495A1 (en) 2018-12-20
AU2022204691A1 (en) 2022-08-04
JP7279991B2 (ja) 2023-05-23
JP2020523381A (ja) 2020-08-06
IL312228B2 (en) 2025-06-01
US20220402962A1 (en) 2022-12-22
CN110753697A (zh) 2020-02-04
IL271159A (en) 2020-01-30
IL312228B1 (en) 2025-02-01
EP3638684C0 (en) 2026-07-08
NZ800534A (en) 2026-03-27
AU2018284131A1 (en) 2020-01-16
EP3638684B1 (en) 2026-07-08
CN110753697B (zh) 2023-10-13
JP7525687B2 (ja) 2024-07-30
ZA201908054B (en) 2026-05-27
GB201709471D0 (en) 2017-07-26
JP2026034703A (ja) 2026-02-27
MX390901B (es) 2025-03-21
CN110785425A (zh) 2020-02-11
AU2024200428C1 (en) 2026-04-30
MX2019014914A (es) 2020-02-13
JP2024138523A (ja) 2024-10-08
CN117486959A (zh) 2024-02-02
US12054511B2 (en) 2024-08-06
PH12019502825A1 (en) 2020-10-26
WO2018229493A3 (en) 2019-02-07
US20250171487A1 (en) 2025-05-29
EP3638685A1 (en) 2020-04-22
JP2023095954A (ja) 2023-07-06
MX2022003822A (es) 2022-05-25
EA201992873A1 (ru) 2020-05-19
MX2019014907A (es) 2020-02-13
KR102920287B1 (ko) 2026-01-30
AU2022204691B2 (en) 2023-11-23
SA519410795B1 (ar) 2023-11-19
KR102695300B1 (ko) 2024-08-16
KR20200016864A (ko) 2020-02-17
IL312228A (en) 2024-06-01
AU2024200428A1 (en) 2024-02-08
WO2018229493A2 (en) 2018-12-20
CA3064177A1 (en) 2018-12-20
JP7248209B2 (ja) 2023-03-29
MA49379A (fr) 2020-04-22
NZ759692A (en) 2026-03-27
EP4786476A2 (en) 2026-08-05
US20200181190A1 (en) 2020-06-11
EP3638684A2 (en) 2020-04-22
CL2019003632A1 (es) 2020-08-14
AU2024200428B2 (en) 2025-10-16
IL302559B1 (en) 2024-05-01
JP2020523378A (ja) 2020-08-06
KR20240127483A (ko) 2024-08-22
IL271159B1 (en) 2023-06-01
CN110785425B (zh) 2023-11-21
BR112019026747A2 (pt) 2020-06-30
AU2018284131B2 (en) 2022-04-07
CA3065682A1 (en) 2018-12-20
US11897913B2 (en) 2024-02-13
IL302559A (en) 2023-07-01