ES2948968T3 - Uso del ribósido de ácido nicotínico o derivados del ribósido de nicotinamida, y derivados reducidos de los mismos, como precursores que aumentan el NAD++ - Google Patents
Uso del ribósido de ácido nicotínico o derivados del ribósido de nicotinamida, y derivados reducidos de los mismos, como precursores que aumentan el NAD++ Download PDFInfo
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- ES2948968T3 ES2948968T3 ES17786649T ES17786649T ES2948968T3 ES 2948968 T3 ES2948968 T3 ES 2948968T3 ES 17786649 T ES17786649 T ES 17786649T ES 17786649 T ES17786649 T ES 17786649T ES 2948968 T3 ES2948968 T3 ES 2948968T3
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- alkyl
- aryl
- heterocycle
- compound
- hydrogen
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- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 title abstract description 98
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical class NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 title abstract description 82
- PUEDDPCUCPRQNY-ZYUZMQFOSA-N D-ribosylnicotinate Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1[N+]1=CC=CC(C([O-])=O)=C1 PUEDDPCUCPRQNY-ZYUZMQFOSA-N 0.000 title abstract 3
- 239000002243 precursor Substances 0.000 title description 21
- 150000003839 salts Chemical class 0.000 claims abstract description 104
- 150000001875 compounds Chemical class 0.000 claims abstract description 99
- 238000000034 method Methods 0.000 claims abstract description 28
- IPXBSAHANXBVMU-OTVLKRCQSA-N 1-[(2R,3R,4R,5R)-3,4-diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)oxolan-2-yl]-2H-pyridine-3-carboxamide Chemical compound C(C)(=O)[C@@]1([C@@H](O[C@@H]([C@]1(O)C(C)=O)C(O)C(C)=O)N1CC(C(=O)N)=CC=C1)O IPXBSAHANXBVMU-OTVLKRCQSA-N 0.000 claims abstract description 4
- BWTZAKFWNOWFCK-OTVLKRCQSA-N 1-[(2R,3R,4R,5R)-3,4-diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)oxolan-2-yl]-2H-pyridine-3-carboxylic acid Chemical compound C(C)(=O)[C@@]1([C@@H](O[C@@H]([C@]1(O)C(C)=O)C(O)C(C)=O)N1CC(C(=O)O)=CC=C1)O BWTZAKFWNOWFCK-OTVLKRCQSA-N 0.000 claims abstract description 4
- QGZHUIXTGFZHJT-OTVLKRCQSA-N 1-[(2R,3R,4R,5R)-3,4-diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)oxolan-2-yl]-4H-pyridine-3-carboxamide Chemical compound C(C)(=O)[C@@]1([C@@H](O[C@@H]([C@]1(O)C(C)=O)C(O)C(C)=O)N1C=C(C(=O)N)CC=C1)O QGZHUIXTGFZHJT-OTVLKRCQSA-N 0.000 claims abstract description 4
- JJICLWRQGDROCF-OTVLKRCQSA-N 1-[(2R,3R,4R,5R)-3,4-diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)oxolan-2-yl]-4H-pyridine-3-carboxylic acid Chemical compound C(C)(=O)[C@@]1([C@@H](O[C@@H]([C@]1(O)C(C)=O)C(O)C(C)=O)N1C=C(C(=O)O)CC=C1)O JJICLWRQGDROCF-OTVLKRCQSA-N 0.000 claims abstract description 4
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- VHOKMYBLRWXLMT-ZYUZMQFOSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4h-pyridine-3-carboxylic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C=C(C(O)=O)CC=C1 VHOKMYBLRWXLMT-ZYUZMQFOSA-N 0.000 claims description 2
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 230000007781 signaling event Effects 0.000 description 1
- 230000003584 silencer Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000005017 substituted alkenyl group Chemical group 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 239000011593 sulfur Chemical group 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical compound C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- XSROQCDVUIHRSI-UHFFFAOYSA-N thietane Chemical compound C1CSC1 XSROQCDVUIHRSI-UHFFFAOYSA-N 0.000 description 1
- VOVUARRWDCVURC-UHFFFAOYSA-N thiirane Chemical compound C1CS1 VOVUARRWDCVURC-UHFFFAOYSA-N 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- DNUYPCSVTPIXRE-UHFFFAOYSA-N tribromomethanesulfonic acid Chemical compound OS(=O)(=O)C(Br)(Br)Br DNUYPCSVTPIXRE-UHFFFAOYSA-N 0.000 description 1
- 229940066528 trichloroacetate Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- VYGSFTVYZHNGBU-UHFFFAOYSA-N trichloromethanesulfonic acid Chemical compound OS(=O)(=O)C(Cl)(Cl)Cl VYGSFTVYZHNGBU-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000008170 walnut oil Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662325264P | 2016-04-20 | 2016-04-20 | |
| PCT/US2017/028673 WO2017184885A1 (en) | 2016-04-20 | 2017-04-20 | Use of nicotinic acid riboside or nicotinamide ribosite derivatives, and reduced derivatives thereof, as nad+increasing precursors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2948968T3 true ES2948968T3 (es) | 2023-09-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17786649T Active ES2948968T3 (es) | 2016-04-20 | 2017-04-20 | Uso del ribósido de ácido nicotínico o derivados del ribósido de nicotinamida, y derivados reducidos de los mismos, como precursores que aumentan el NAD++ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10183036B2 (OSRAM) |
| EP (1) | EP3445359B8 (OSRAM) |
| JP (3) | JP7089480B2 (OSRAM) |
| KR (1) | KR20190008246A (OSRAM) |
| CN (1) | CN109640984A (OSRAM) |
| AU (2) | AU2017254657A1 (OSRAM) |
| BR (1) | BR112018071573A2 (OSRAM) |
| CA (1) | CA3021571C (OSRAM) |
| ES (1) | ES2948968T3 (OSRAM) |
| MX (1) | MX393076B (OSRAM) |
| NZ (1) | NZ747693A (OSRAM) |
| WO (1) | WO2017184885A1 (OSRAM) |
| ZA (1) | ZA201807736B (OSRAM) |
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| WO2017011788A1 (en) | 2015-07-15 | 2017-01-19 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| EP3331894B1 (en) | 2015-08-05 | 2021-02-17 | Metro International Biotech, LLC | Nicotinamide mononucleotide derivatives and their uses |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| NZ803738A (en) | 2016-11-11 | 2024-05-31 | Chromadex Inc | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| JP7136795B2 (ja) | 2016-11-29 | 2022-09-13 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 母体の健康および／または子の健康を向上させるためのｎａｄ前駆体の使用 |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| WO2018191771A1 (en) * | 2017-04-18 | 2018-10-25 | Victor Chang Cardiac Research Institute | Detection and treatment of congenital malformations |
| US11286274B2 (en) | 2017-06-19 | 2022-03-29 | Mitopower Llc | Nicotinamide riboside derivatives and their uses |
| WO2019152416A1 (en) * | 2018-01-30 | 2019-08-08 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| WO2019226755A1 (en) * | 2018-05-22 | 2019-11-28 | Jumpstart Fertility Pty Ltd | Amino acid salts of nicotinic acid ribosides as anti-aging agents |
| EP3897666A2 (en) | 2018-12-17 | 2021-10-27 | Mitopower LLC | Nicotinyl riboside compounds and their uses |
| BR112021016432A2 (pt) | 2019-02-21 | 2021-11-09 | Chromadex Inc | Composição que compreende prills de cera, processo para produzir prills de cera, composição nutricional, alimento, bebida ou suplemento alimentar que compreende prills de cera, e composição que compreende microesferas encapsuladas |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| EP3980027A1 (en) * | 2019-06-05 | 2022-04-13 | Société des Produits Nestlé S.A. | Reduced nicotinamideribosides for the treatment/prevention of liver disease |
| BR112021021690A2 (pt) * | 2019-06-05 | 2022-02-15 | Nestle Sa | Ribosídeos de nicotinamida reduzidos para tratamento/prevenção de doenças do músculo esquelético |
| EP3980026B1 (en) * | 2019-06-05 | 2024-07-31 | Société des Produits Nestlé S.A. | Reduced nicotinamide ribosides for treating or preventing kidney disease |
| CN110973260A (zh) * | 2019-12-11 | 2020-04-10 | 杨力 | 一种含有烟酰胺核糖苷的牛奶及其制备方法与应用 |
| EP4076458A1 (en) | 2019-12-19 | 2022-10-26 | Leibniz-lnstitut Für Altersforschung | Nad-precursors and dietary restriction for treating age-related medical conditions |
| EP4117677A1 (en) * | 2020-03-09 | 2023-01-18 | Société des Produits Nestlé S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of cardiovascular diseases and conditions |
| WO2021180739A1 (en) * | 2020-03-09 | 2021-09-16 | Société des Produits Nestlé S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of viral and bacterial infections |
| EP4117678A1 (en) * | 2020-03-09 | 2023-01-18 | Société des Produits Nestlé S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of neurological diseases and conditions |
| US20230138327A1 (en) * | 2020-03-09 | 2023-05-04 | Societe Des Produits Nestle S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of pancreatic diseases and conditions |
| CN114561342B (zh) * | 2020-11-27 | 2024-12-20 | 西安交通大学医学院第一附属医院 | Nad信号通路激动剂在体外胚胎培养中的应用 |
| CN115669929A (zh) * | 2021-01-15 | 2023-02-03 | 江苏恒正合生命科学有限公司 | 辅助改善记忆的功能性食品其制备方法 |
| CN118201621A (zh) * | 2021-05-05 | 2024-06-14 | 雀巢产品有限公司 | 使用narh和nr的组合来产生细胞内烟酰胺腺嘌呤二核苷酸（nad+）的组合物和方法 |
| KR20240020716A (ko) | 2021-05-27 | 2024-02-15 | 메트로 인터내셔널 바이오테크 엘엘씨 | 니코틴산 모노뉴클레오타이드 및 이의 에스터의 결정질 고체 및 제조 및 사용 방법 |
| EP4313067A4 (en) * | 2021-06-18 | 2024-12-18 | Mitopower LLC | TREATMENT OF IMMUNITY-RELATED DISORDERS, RENAL DISORDERS, LIVER DISORDERS, HEMOLYTIC DISORDERS AND OXIDATIVE STRESS-RELATED DISORDERS USING NRH, NARH AND THEIR REDUCED DERIVATIVES |
| EP4422644A4 (en) * | 2021-10-27 | 2025-08-27 | Elysium Health Inc | METHODS OF TREATING MENOPAUSAL SYNDROMES |
| JP7111878B1 (ja) | 2021-10-27 | 2022-08-02 | 旭化成ファーマ株式会社 | ニコチンアミドモノヌクレオチドの製造方法 |
| WO2023150072A1 (en) | 2022-02-01 | 2023-08-10 | Sinclair David A | Compositions and methods for the preservation of plant matter |
| WO2023150667A2 (en) * | 2022-02-04 | 2023-08-10 | Elysium Health Inc. | Ribose linkers and conjugates thereof |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
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| US7022680B2 (en) | 2002-05-30 | 2006-04-04 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US7927859B2 (en) * | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| EP1723227A4 (en) | 2004-02-10 | 2007-09-19 | Dartmouth College | NICOTINAMIDRIBOSIDE KINASE COMPOSITIONS AND METHOD FOR THEIR USE |
| EP3006040B1 (en) | 2004-06-04 | 2017-11-22 | Washington University | Methods and compositions for treating neuropathies |
| ES2670927T3 (es) * | 2005-11-18 | 2018-06-04 | Cornell Research Foundation, Inc. | Composiciones de nicotinoil ribósido y métodos de uso |
| GB201313465D0 (en) | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| CA2928656C (en) | 2013-10-30 | 2020-07-28 | ChromaDex Inc. | Nicotinamide riboside compositions for topical use in treating skin conditions |
| CN106715455A (zh) * | 2014-06-06 | 2017-05-24 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 烟酰胺核苷类似物及其药物组合物和用途 |
| EP3271370B1 (en) * | 2015-03-16 | 2023-06-21 | Chromadex Inc. | Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof |
| WO2017011788A1 (en) | 2015-07-15 | 2017-01-19 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| EP3331894B1 (en) | 2015-08-05 | 2021-02-17 | Metro International Biotech, LLC | Nicotinamide mononucleotide derivatives and their uses |
| CA3021022C (en) * | 2016-04-14 | 2024-04-23 | ChromaDex Inc. | Use of nicotinamide riboside, nicotinic acid riboside, nicotinamide mononucleotide, and nicotinoyl compound derivatives in infant formula |
-
2017
- 2017-04-20 CA CA3021571A patent/CA3021571C/en active Active
- 2017-04-20 AU AU2017254657A patent/AU2017254657A1/en not_active Abandoned
- 2017-04-20 KR KR1020187033413A patent/KR20190008246A/ko not_active Ceased
- 2017-04-20 BR BR112018071573-5A patent/BR112018071573A2/pt not_active Application Discontinuation
- 2017-04-20 ES ES17786649T patent/ES2948968T3/es active Active
- 2017-04-20 US US15/492,952 patent/US10183036B2/en active Active
- 2017-04-20 JP JP2018554765A patent/JP7089480B2/ja active Active
- 2017-04-20 MX MX2018012849A patent/MX393076B/es unknown
- 2017-04-20 NZ NZ747693A patent/NZ747693A/en unknown
- 2017-04-20 EP EP17786649.8A patent/EP3445359B8/en active Active
- 2017-04-20 CN CN201780038245.5A patent/CN109640984A/zh active Pending
- 2017-04-20 WO PCT/US2017/028673 patent/WO2017184885A1/en not_active Ceased
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2018
- 2018-11-16 ZA ZA2018/07736A patent/ZA201807736B/en unknown
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2021
- 2021-07-16 JP JP2021117648A patent/JP2021176871A/ja active Pending
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2022
- 2022-08-22 AU AU2022221384A patent/AU2022221384C1/en active Active
- 2022-10-19 JP JP2022167877A patent/JP7493007B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201807736B (en) | 2020-05-27 |
| BR112018071573A2 (pt) | 2019-02-12 |
| CA3021571C (en) | 2023-01-03 |
| CN109640984A (zh) | 2019-04-16 |
| WO2017184885A1 (en) | 2017-10-26 |
| JP7493007B2 (ja) | 2024-05-30 |
| JP2023002685A (ja) | 2023-01-10 |
| MX393076B (es) | 2025-03-24 |
| US10183036B2 (en) | 2019-01-22 |
| AU2022221384C1 (en) | 2023-08-03 |
| JP7089480B2 (ja) | 2022-06-22 |
| AU2022221384A1 (en) | 2022-09-22 |
| MX2018012849A (es) | 2019-08-29 |
| NZ747693A (en) | 2023-07-28 |
| JP2019514874A (ja) | 2019-06-06 |
| CA3021571A1 (en) | 2017-10-26 |
| JP2021176871A (ja) | 2021-11-11 |
| US20170304338A1 (en) | 2017-10-26 |
| AU2022221384B2 (en) | 2023-03-23 |
| EP3445359A1 (en) | 2019-02-27 |
| EP3445359A4 (en) | 2019-12-25 |
| AU2017254657A1 (en) | 2018-11-15 |
| KR20190008246A (ko) | 2019-01-23 |
| EP3445359C0 (en) | 2023-06-07 |
| WO2017184885A8 (en) | 2023-08-24 |
| EP3445359B1 (en) | 2023-06-07 |
| EP3445359B8 (en) | 2023-09-06 |
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