ES2932801T3 - Composiciones de ribósido de nicotinamida y pterostilbeno y métodos para el tratamiento de trastornos de la piel - Google Patents

Composiciones de ribósido de nicotinamida y pterostilbeno y métodos para el tratamiento de trastornos de la piel Download PDF

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Publication number
ES2932801T3
ES2932801T3 ES16807940T ES16807940T ES2932801T3 ES 2932801 T3 ES2932801 T3 ES 2932801T3 ES 16807940 T ES16807940 T ES 16807940T ES 16807940 T ES16807940 T ES 16807940T ES 2932801 T3 ES2932801 T3 ES 2932801T3
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Spain
Prior art keywords
composition
pterostilbene
substituted
therapeutically effective
nicotinamide riboside
Prior art date
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Active
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ES16807940T
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English (en)
Spanish (es)
Inventor
Eric Marcotulli
Leonard Guarente
Daniel Alminana
Paul Bowen
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Elysium Health Inc
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Elysium Health Inc
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Publication of ES2932801T3 publication Critical patent/ES2932801T3/es
Active legal-status Critical Current
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/004Aftersun preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ES16807940T 2015-06-10 2016-02-25 Composiciones de ribósido de nicotinamida y pterostilbeno y métodos para el tratamiento de trastornos de la piel Active ES2932801T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562173733P 2015-06-10 2015-06-10
PCT/US2016/019653 WO2016200447A1 (en) 2015-06-10 2016-02-25 Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders

Publications (1)

Publication Number Publication Date
ES2932801T3 true ES2932801T3 (es) 2023-01-26

Family

ID=57503873

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16807940T Active ES2932801T3 (es) 2015-06-10 2016-02-25 Composiciones de ribósido de nicotinamida y pterostilbeno y métodos para el tratamiento de trastornos de la piel

Country Status (13)

Country Link
US (2) US11426398B2 (enExample)
EP (1) EP3307754B1 (enExample)
JP (1) JP2018517774A (enExample)
KR (1) KR20180021784A (enExample)
CN (1) CN107849083A (enExample)
AU (2) AU2016274126A1 (enExample)
CA (1) CA2989115C (enExample)
ES (1) ES2932801T3 (enExample)
MX (2) MX389207B (enExample)
RU (1) RU2017145692A (enExample)
TW (1) TWI725033B (enExample)
WO (1) WO2016200447A1 (enExample)
ZA (1) ZA201800056B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016274126A1 (en) 2015-06-10 2018-01-18 Elysium Health, Inc. Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders
US20180325931A1 (en) 2017-01-21 2018-11-15 Ningbo Zhiming Biotechnology Co., Ltd. Use of paeoniflorin-6'-o-benzenesulfonate in treatment of sjögren's syndrome
ES3014265T3 (en) 2017-03-17 2025-04-21 Elysium Health Inc Combination of nicotinamide riboside and pterostilbene for use in treating or preventing liver damage
JP2020517736A (ja) * 2017-04-24 2020-06-18 エリシウム ヘルス,インコーポレーテッド 腎臓損傷の治療及び予防
JP7143402B2 (ja) * 2017-05-17 2022-09-28 ウニベルシタ デ バレンシア-エストゥディ ヘネラル ニコチンアミドリボシドを使用する運動ニューロン疾患の治療及び予防
WO2018213715A1 (en) * 2017-05-18 2018-11-22 Elysium Health, Inc. Methods and compositions for improving sleep
CN111542312A (zh) * 2017-07-28 2020-08-14 老龄化控制中心股份公司 预防和逆转衰老方面的组合物和方法
CN109589309A (zh) * 2017-09-30 2019-04-09 浙江嘉华化工有限公司 烟酰胺核糖微囊的制备方法
CN111601814A (zh) * 2017-10-19 2020-08-28 益力舒健康公司 Tdp-43相关疾病的预防和治疗
US20210186996A1 (en) * 2017-12-01 2021-06-24 Elysium Health, Inc. Methods and compositions for treating multiple sclerosis
WO2019108875A1 (en) * 2017-12-01 2019-06-06 Elysium Health, Inc. Methods and compositions for treating glaucoma
GB201811312D0 (en) * 2018-07-10 2018-08-29 Nuchido Ltd Compositions
SG11202102204PA (en) 2018-09-25 2021-04-29 Ponce De Leon Health Designated Activity Company Process of making calcium alpha-ketoglutarate
CN111569084B (zh) * 2019-02-19 2021-07-13 中国科学院上海药物研究所 基于柳胺酚和紫檀芪的成环偶联分子dcz0801类化合物、其制备方法及用途
WO2020176445A1 (en) * 2019-02-26 2020-09-03 Universitat De Valencia-Estudi General Methods and compositions for treating motor neuron diseases
WO2020190703A1 (en) * 2019-03-21 2020-09-24 Elysium Health, Inc. Methods for wound treatment
CN113768946A (zh) * 2020-05-25 2021-12-10 南京帝昌医药科技有限公司 一种治疗糖尿病皮肤并发症的软膏及其制备方法
CN113712193A (zh) * 2020-05-25 2021-11-30 南京帝昌医药科技有限公司 修复皮肤系统的组合物制备方法及其用途
US20230270770A1 (en) * 2020-07-30 2023-08-31 Moises HERNANDEZ-VAZQUEZ Nutritional supplements for repairing muscle and defending against deterioration from human aging
EP4380577A1 (en) * 2021-08-02 2024-06-12 Nuvamid SA Nicotinamide mononucleotide derivatives for use in the treatment of sapho syndrome
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
ES2670927T3 (es) * 2005-11-18 2018-06-04 Cornell Research Foundation, Inc. Composiciones de nicotinoil ribósido y métodos de uso
EP2322159A1 (en) 2009-10-30 2011-05-18 Green Molecular, S.L. Use of pterostilbene (pter) as medicament for prevention and/or treatment of skin diseases, damages or injures or as cosmetic
CN103547256A (zh) 2011-03-23 2014-01-29 加利福尼亚大学校务委员会 炎性和传染性皮肤病的治疗
US8841350B2 (en) 2011-05-11 2014-09-23 ChromaDex Inc. Method for inducing UDP-glucuronosyltransferase activity using pterostilbene
US20130296440A1 (en) 2012-05-01 2013-11-07 ChromaDex Inc. Pterostilbene and curcumin combination for treatment of oxidative stress and inflammation
CA2928656C (en) * 2013-10-30 2020-07-28 ChromaDex Inc. Nicotinamide riboside compositions for topical use in treating skin conditions
CN106715455A (zh) * 2014-06-06 2017-05-24 葛兰素史密斯克莱知识产权(第2 号)有限公司 烟酰胺核苷类似物及其药物组合物和用途
EP3271370B1 (en) 2015-03-16 2023-06-21 Chromadex Inc. Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof
US20180071273A1 (en) * 2015-03-17 2018-03-15 Speccialty Nutrition Group, Inc. Nutritional compositions to enhance mitochondrial energy production
AU2016274126A1 (en) 2015-06-10 2018-01-18 Elysium Health, Inc. Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders

Also Published As

Publication number Publication date
AU2020286208A1 (en) 2021-01-07
RU2017145692A (ru) 2019-07-10
AU2016274126A1 (en) 2018-01-18
CN107849083A (zh) 2018-03-27
EP3307754A1 (en) 2018-04-18
TW201713322A (zh) 2017-04-16
MX2021012600A (es) 2021-11-12
EP3307754B1 (en) 2022-09-14
CA2989115C (en) 2024-01-02
CA2989115A1 (en) 2016-12-15
US12109206B2 (en) 2024-10-08
RU2017145692A3 (enExample) 2019-07-31
MX2017016024A (es) 2018-08-15
KR20180021784A (ko) 2018-03-05
US20180353497A1 (en) 2018-12-13
EP3307754A4 (en) 2019-03-27
WO2016200447A1 (en) 2016-12-15
US11426398B2 (en) 2022-08-30
MX389207B (es) 2025-03-20
JP2018517774A (ja) 2018-07-05
TWI725033B (zh) 2021-04-21
US20220362233A1 (en) 2022-11-17
ZA201800056B (en) 2023-10-25
AU2020286208B2 (en) 2022-11-10

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