TWI725033B - 用於治療皮膚疾病之菸鹼醯胺核苷及紫檀芪組合物及方法 - Google Patents

用於治療皮膚疾病之菸鹼醯胺核苷及紫檀芪組合物及方法 Download PDF

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TWI725033B
TWI725033B TW105118370A TW105118370A TWI725033B TW I725033 B TWI725033 B TW I725033B TW 105118370 A TW105118370 A TW 105118370A TW 105118370 A TW105118370 A TW 105118370A TW I725033 B TWI725033 B TW I725033B
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substituted
therapeutically effective
effective amount
pterostilbene
use according
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TW105118370A
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TW201713322A (zh
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艾瑞克 亞歷山大 馬可托利
萊納德 珀欣 瓜倫特
丹尼爾 安東尼奧 艾米納納
保羅 邁克爾 鮑文
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美商伊利司保健股份有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/004Aftersun preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
TW105118370A 2015-06-10 2016-06-13 用於治療皮膚疾病之菸鹼醯胺核苷及紫檀芪組合物及方法 TWI725033B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562173733P 2015-06-10 2015-06-10
US62/173,733 2015-06-10

Publications (2)

Publication Number Publication Date
TW201713322A TW201713322A (zh) 2017-04-16
TWI725033B true TWI725033B (zh) 2021-04-21

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TW105118370A TWI725033B (zh) 2015-06-10 2016-06-13 用於治療皮膚疾病之菸鹼醯胺核苷及紫檀芪組合物及方法

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US (2) US11426398B2 (enExample)
EP (1) EP3307754B1 (enExample)
JP (1) JP2018517774A (enExample)
KR (1) KR20180021784A (enExample)
CN (1) CN107849083A (enExample)
AU (2) AU2016274126A1 (enExample)
CA (1) CA2989115C (enExample)
ES (1) ES2932801T3 (enExample)
MX (2) MX389207B (enExample)
RU (1) RU2017145692A (enExample)
TW (1) TWI725033B (enExample)
WO (1) WO2016200447A1 (enExample)
ZA (1) ZA201800056B (enExample)

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US20180325931A1 (en) 2017-01-21 2018-11-15 Ningbo Zhiming Biotechnology Co., Ltd. Use of paeoniflorin-6'-o-benzenesulfonate in treatment of sjögren's syndrome
ES3014265T3 (en) 2017-03-17 2025-04-21 Elysium Health Inc Combination of nicotinamide riboside and pterostilbene for use in treating or preventing liver damage
JP2020517736A (ja) * 2017-04-24 2020-06-18 エリシウム ヘルス,インコーポレーテッド 腎臓損傷の治療及び予防
JP7143402B2 (ja) * 2017-05-17 2022-09-28 ウニベルシタ デ バレンシア-エストゥディ ヘネラル ニコチンアミドリボシドを使用する運動ニューロン疾患の治療及び予防
WO2018213715A1 (en) * 2017-05-18 2018-11-22 Elysium Health, Inc. Methods and compositions for improving sleep
CN111542312A (zh) * 2017-07-28 2020-08-14 老龄化控制中心股份公司 预防和逆转衰老方面的组合物和方法
CN109589309A (zh) * 2017-09-30 2019-04-09 浙江嘉华化工有限公司 烟酰胺核糖微囊的制备方法
CN111601814A (zh) * 2017-10-19 2020-08-28 益力舒健康公司 Tdp-43相关疾病的预防和治疗
US20210186996A1 (en) * 2017-12-01 2021-06-24 Elysium Health, Inc. Methods and compositions for treating multiple sclerosis
WO2019108875A1 (en) * 2017-12-01 2019-06-06 Elysium Health, Inc. Methods and compositions for treating glaucoma
GB201811312D0 (en) * 2018-07-10 2018-08-29 Nuchido Ltd Compositions
SG11202102204PA (en) 2018-09-25 2021-04-29 Ponce De Leon Health Designated Activity Company Process of making calcium alpha-ketoglutarate
CN111569084B (zh) * 2019-02-19 2021-07-13 中国科学院上海药物研究所 基于柳胺酚和紫檀芪的成环偶联分子dcz0801类化合物、其制备方法及用途
WO2020176445A1 (en) * 2019-02-26 2020-09-03 Universitat De Valencia-Estudi General Methods and compositions for treating motor neuron diseases
WO2020190703A1 (en) * 2019-03-21 2020-09-24 Elysium Health, Inc. Methods for wound treatment
CN113768946A (zh) * 2020-05-25 2021-12-10 南京帝昌医药科技有限公司 一种治疗糖尿病皮肤并发症的软膏及其制备方法
CN113712193A (zh) * 2020-05-25 2021-11-30 南京帝昌医药科技有限公司 修复皮肤系统的组合物制备方法及其用途
US20230270770A1 (en) * 2020-07-30 2023-08-31 Moises HERNANDEZ-VAZQUEZ Nutritional supplements for repairing muscle and defending against deterioration from human aging
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Publication number Publication date
AU2020286208A1 (en) 2021-01-07
RU2017145692A (ru) 2019-07-10
AU2016274126A1 (en) 2018-01-18
CN107849083A (zh) 2018-03-27
EP3307754A1 (en) 2018-04-18
TW201713322A (zh) 2017-04-16
MX2021012600A (es) 2021-11-12
EP3307754B1 (en) 2022-09-14
CA2989115C (en) 2024-01-02
CA2989115A1 (en) 2016-12-15
US12109206B2 (en) 2024-10-08
RU2017145692A3 (enExample) 2019-07-31
MX2017016024A (es) 2018-08-15
KR20180021784A (ko) 2018-03-05
US20180353497A1 (en) 2018-12-13
EP3307754A4 (en) 2019-03-27
WO2016200447A1 (en) 2016-12-15
US11426398B2 (en) 2022-08-30
MX389207B (es) 2025-03-20
JP2018517774A (ja) 2018-07-05
US20220362233A1 (en) 2022-11-17
ZA201800056B (en) 2023-10-25
AU2020286208B2 (en) 2022-11-10
ES2932801T3 (es) 2023-01-26

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