ES2875853T3 - Método de tratar fibrosis - Google Patents

Método de tratar fibrosis Download PDF

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Publication number
ES2875853T3
ES2875853T3 ES14762435T ES14762435T ES2875853T3 ES 2875853 T3 ES2875853 T3 ES 2875853T3 ES 14762435 T ES14762435 T ES 14762435T ES 14762435 T ES14762435 T ES 14762435T ES 2875853 T3 ES2875853 T3 ES 2875853T3
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ES
Spain
Prior art keywords
peptide
fibroblasts
csp
upa
expression
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Active
Application number
ES14762435T
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English (en)
Spanish (es)
Inventor
Sreerama Shetty
Steven Idell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES14762435T 2013-03-15 2014-03-17 Método de tratar fibrosis Active ES2875853T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361800117P 2013-03-15 2013-03-15
PCT/US2014/030147 WO2014145389A1 (en) 2013-03-15 2014-03-17 Inhibition of pulmonary fibrosis with nutlin-3a and peptides

Publications (1)

Publication Number Publication Date
ES2875853T3 true ES2875853T3 (es) 2021-11-11

Family

ID=51537978

Family Applications (2)

Application Number Title Priority Date Filing Date
ES14762435T Active ES2875853T3 (es) 2013-03-15 2014-03-17 Método de tratar fibrosis
ES21168926T Active ES2993671T3 (en) 2013-03-15 2014-03-17 Peptide fttftvt for use in treating fibrosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES21168926T Active ES2993671T3 (en) 2013-03-15 2014-03-17 Peptide fttftvt for use in treating fibrosis

Country Status (11)

Country Link
US (8) US9630990B2 (enExample)
EP (3) EP2970383B1 (enExample)
JP (4) JP6603207B2 (enExample)
KR (3) KR102268883B1 (enExample)
CN (3) CN110201144B (enExample)
AU (3) AU2014233055B2 (enExample)
CA (1) CA2904870C (enExample)
DK (2) DK3929207T3 (enExample)
ES (2) ES2875853T3 (enExample)
PT (2) PT2970383T (enExample)
WO (1) WO2014145389A1 (enExample)

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ES2875853T3 (es) * 2013-03-15 2021-11-11 Univ Texas Método de tratar fibrosis
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Also Published As

Publication number Publication date
JP2016522159A (ja) 2016-07-28
ES2993671T3 (en) 2025-01-03
KR20210076190A (ko) 2021-06-23
CN105263948B (zh) 2019-06-04
EP3929207A1 (en) 2021-12-29
PT2970383T (pt) 2021-06-03
KR20230148263A (ko) 2023-10-24
US20230100467A1 (en) 2023-03-30
KR102268883B1 (ko) 2021-06-28
CN110201144A (zh) 2019-09-06
US20220098239A1 (en) 2022-03-31
US20250304619A1 (en) 2025-10-02
EP2970383A1 (en) 2016-01-20
AU2020203192A1 (en) 2020-06-04
CN117679487A (zh) 2024-03-12
CN105263948A (zh) 2016-01-20
PT3929207T (pt) 2024-10-21
US10377796B2 (en) 2019-08-13
JP6603207B2 (ja) 2019-11-06
EP4438044A3 (en) 2024-12-04
US9630990B2 (en) 2017-04-25
US11161875B2 (en) 2021-11-02
KR20150128731A (ko) 2015-11-18
US11780879B2 (en) 2023-10-10
CA2904870A1 (en) 2014-09-18
JP2021178856A (ja) 2021-11-18
KR102588702B1 (ko) 2023-10-16
US20170253632A1 (en) 2017-09-07
JP2023178440A (ja) 2023-12-14
DK2970383T3 (da) 2021-07-05
WO2014145389A1 (en) 2014-09-18
DK3929207T3 (da) 2024-10-21
EP2970383A4 (en) 2016-12-21
US20240059736A1 (en) 2024-02-22
US20160272678A1 (en) 2016-09-22
AU2014233055B2 (en) 2018-08-09
EP2970383B1 (en) 2021-04-21
JP6975690B2 (ja) 2021-12-01
US20180086791A1 (en) 2018-03-29
CN110201144B (zh) 2024-01-02
EP4438044A2 (en) 2024-10-02
US12173089B2 (en) 2024-12-24
BR112015023287A2 (pt) 2019-11-19
HK1218924A1 (zh) 2017-03-17
JP2018158952A (ja) 2018-10-11
US20200165298A1 (en) 2020-05-28
JP7378833B2 (ja) 2023-11-14
CA2904870C (en) 2022-08-23
EP3929207B1 (en) 2024-07-17
AU2018205157A1 (en) 2018-08-02
AU2014233055A1 (en) 2015-10-01

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