CA2904870C - Inhibition of pulmonary fibrosis with nutlin-3a and peptides - Google Patents

Inhibition of pulmonary fibrosis with nutlin-3a and peptides Download PDF

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Publication number
CA2904870C
CA2904870C CA2904870A CA2904870A CA2904870C CA 2904870 C CA2904870 C CA 2904870C CA 2904870 A CA2904870 A CA 2904870A CA 2904870 A CA2904870 A CA 2904870A CA 2904870 C CA2904870 C CA 2904870C
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composition
fibroblasts
seq
peptide
csp
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CA2904870A
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English (en)
French (fr)
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CA2904870A1 (en
Inventor
Sreerama Shetty
Steven Idell
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The University of Texas System
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The University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2904870A 2013-03-15 2014-03-17 Inhibition of pulmonary fibrosis with nutlin-3a and peptides Active CA2904870C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361800117P 2013-03-15 2013-03-15
US61/800,117 2013-03-15
PCT/US2014/030147 WO2014145389A1 (en) 2013-03-15 2014-03-17 Inhibition of pulmonary fibrosis with nutlin-3a and peptides

Publications (2)

Publication Number Publication Date
CA2904870A1 CA2904870A1 (en) 2014-09-18
CA2904870C true CA2904870C (en) 2022-08-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2904870A Active CA2904870C (en) 2013-03-15 2014-03-17 Inhibition of pulmonary fibrosis with nutlin-3a and peptides

Country Status (11)

Country Link
US (8) US9630990B2 (enExample)
EP (3) EP4438044A3 (enExample)
JP (4) JP6603207B2 (enExample)
KR (3) KR20230148263A (enExample)
CN (3) CN105263948B (enExample)
AU (3) AU2014233055B2 (enExample)
CA (1) CA2904870C (enExample)
DK (2) DK3929207T3 (enExample)
ES (2) ES2875853T3 (enExample)
PT (2) PT2970383T (enExample)
WO (1) WO2014145389A1 (enExample)

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Also Published As

Publication number Publication date
PT2970383T (pt) 2021-06-03
KR20230148263A (ko) 2023-10-24
US11780879B2 (en) 2023-10-10
EP2970383A4 (en) 2016-12-21
JP2021178856A (ja) 2021-11-18
US20180086791A1 (en) 2018-03-29
EP2970383B1 (en) 2021-04-21
JP2018158952A (ja) 2018-10-11
AU2020203192A1 (en) 2020-06-04
EP3929207A1 (en) 2021-12-29
EP4438044A3 (en) 2024-12-04
JP6975690B2 (ja) 2021-12-01
JP7378833B2 (ja) 2023-11-14
HK1218924A1 (zh) 2017-03-17
US20220098239A1 (en) 2022-03-31
US20240059736A1 (en) 2024-02-22
KR20150128731A (ko) 2015-11-18
KR102588702B1 (ko) 2023-10-16
US11161875B2 (en) 2021-11-02
US10377796B2 (en) 2019-08-13
CN110201144A (zh) 2019-09-06
US12173089B2 (en) 2024-12-24
JP2016522159A (ja) 2016-07-28
CN105263948A (zh) 2016-01-20
US20200165298A1 (en) 2020-05-28
BR112015023287A2 (pt) 2019-11-19
PT3929207T (pt) 2024-10-21
EP3929207B1 (en) 2024-07-17
KR102268883B1 (ko) 2021-06-28
ES2875853T3 (es) 2021-11-11
US20170253632A1 (en) 2017-09-07
JP6603207B2 (ja) 2019-11-06
JP2023178440A (ja) 2023-12-14
US20250304619A1 (en) 2025-10-02
AU2014233055B2 (en) 2018-08-09
CN105263948B (zh) 2019-06-04
KR20210076190A (ko) 2021-06-23
US20230100467A1 (en) 2023-03-30
EP2970383A1 (en) 2016-01-20
CN117679487A (zh) 2024-03-12
DK2970383T3 (da) 2021-07-05
CA2904870A1 (en) 2014-09-18
CN110201144B (zh) 2024-01-02
DK3929207T3 (da) 2024-10-21
AU2018205157A1 (en) 2018-08-02
WO2014145389A1 (en) 2014-09-18
AU2014233055A1 (en) 2015-10-01
US20160272678A1 (en) 2016-09-22
US9630990B2 (en) 2017-04-25
ES2993671T3 (en) 2025-01-03
EP4438044A2 (en) 2024-10-02

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