ES2870174T3 - Proteínas de fusión PD-1-CD28 y su uso en medicina - Google Patents

Proteínas de fusión PD-1-CD28 y su uso en medicina Download PDF

Info

Publication number
ES2870174T3
ES2870174T3 ES16736802T ES16736802T ES2870174T3 ES 2870174 T3 ES2870174 T3 ES 2870174T3 ES 16736802 T ES16736802 T ES 16736802T ES 16736802 T ES16736802 T ES 16736802T ES 2870174 T3 ES2870174 T3 ES 2870174T3
Authority
ES
Spain
Prior art keywords
cells
seq
fusion protein
nucleic acid
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16736802T
Other languages
English (en)
Spanish (es)
Inventor
Sebastian Kobold
Stefan Endres
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2870174T3 publication Critical patent/ES2870174T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES16736802T 2015-06-19 2016-06-20 Proteínas de fusión PD-1-CD28 y su uso en medicina Active ES2870174T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15172913 2015-06-19
PCT/EP2016/064195 WO2016203048A1 (en) 2015-06-19 2016-06-20 Pd-1-cd28 fusion proteins and their use in medicine

Publications (1)

Publication Number Publication Date
ES2870174T3 true ES2870174T3 (es) 2021-10-26

Family

ID=53476720

Family Applications (2)

Application Number Title Priority Date Filing Date
ES16736802T Active ES2870174T3 (es) 2015-06-19 2016-06-20 Proteínas de fusión PD-1-CD28 y su uso en medicina
ES21155542T Active ES2976647T3 (es) 2015-06-19 2016-06-20 Proteínas de fusión PD-1-CD28 y su uso en medicina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES21155542T Active ES2976647T3 (es) 2015-06-19 2016-06-20 Proteínas de fusión PD-1-CD28 y su uso en medicina

Country Status (13)

Country Link
US (2) US11192935B2 (enExample)
EP (3) EP3909972B1 (enExample)
JP (3) JP7085988B2 (enExample)
CN (3) CN115927474A (enExample)
AU (1) AU2016277883B2 (enExample)
CA (1) CA2989949A1 (enExample)
DK (2) DK3909972T5 (enExample)
ES (2) ES2870174T3 (enExample)
FI (1) FI3909972T3 (enExample)
HU (1) HUE054201T2 (enExample)
PL (1) PL3310805T3 (enExample)
PT (1) PT3310805T (enExample)
WO (1) WO2016203048A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107531805A (zh) 2015-03-05 2018-01-02 弗雷德哈钦森癌症研究中心 免疫调节融合蛋白及其用途
BR112017024757A2 (pt) 2015-05-18 2018-11-13 TCR2 Therapeutics Inc. composições e métodos para reprogramação de tcr utilizando proteínas de fusão
CN115927474A (zh) 2015-06-19 2023-04-07 塞巴斯蒂安·科博尔德 Pd-1-cd28融合蛋白及其在医学中的用途
US20180185434A1 (en) * 2015-06-29 2018-07-05 The Johns Hopkins University Immune checkpoint chimeric antigen receptors therapy
CN105331585A (zh) * 2015-11-13 2016-02-17 科济生物医药（上海）有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
WO2017162797A1 (en) * 2016-03-23 2017-09-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Fusion proteins of pd-1 and 4-1bb
CN107523545A (zh) * 2016-06-20 2017-12-29 上海细胞治疗研究院 一种高效稳定表达抗体的杀伤性细胞及其用途
AU2017291262A1 (en) * 2016-06-30 2019-01-03 F. Hoffmann-La Roche Ag Improved adoptive T-cell therapy
WO2018026953A1 (en) 2016-08-02 2018-02-08 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
MX2019003899A (es) 2016-10-07 2019-08-14 Tcr2 Therapeutics Inc Composiciones y metodos para reprogramacion de receptores de linfocitos t mediante el uso de proteinas de fusion.
AU2017363311A1 (en) 2016-11-22 2019-06-13 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
JP2020513754A (ja) * 2016-12-21 2020-05-21 ティーシーアール２ セラピューティクス インク． がん治療用に操作されたｔ細胞
EP3574005B1 (en) * 2017-01-26 2021-12-15 Novartis AG Cd28 compositions and methods for chimeric antigen receptor therapy
MX2019010812A (es) 2017-03-17 2019-12-11 Hutchinson Fred Cancer Res Proteinas de fusion inmunomoduladoras y sus usos.
WO2019173324A1 (en) * 2018-03-06 2019-09-12 The Trustees Of The University Of Pennsylvania Prostate-specific membrane antigen cars and methods of use thereof
CN108727504B (zh) * 2018-04-16 2021-08-27 泉州向日葵生物科技有限公司 一种ifn与抗pd-l1抗体的融合蛋白及其应用
CN111606999B (zh) * 2019-02-26 2022-09-06 南京惟亚德生物医药有限公司 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用
JP7654557B2 (ja) * 2019-03-27 2025-04-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法
EP3999079A4 (en) * 2019-07-19 2024-04-03 Memorial Sloan Kettering Cancer Center Fusion polypeptide for immunotherapy
CN113832111A (zh) * 2020-06-23 2021-12-24 南京大学 一种类外泌体技术用于制备新型溶瘤病毒的方法
CN113832114A (zh) * 2020-06-23 2021-12-24 南京大学 一种新型溶瘤腺病毒EM/VSV-G Ad5-P及其在制备抗肿瘤药物中的应用
EP4305174A4 (en) * 2021-03-10 2025-04-30 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University REPORTER CELLS EXPRESSING CHIMERIC POLYPEPTIDES TO DETERMINE THE PRESENCE AND/OR ACTIVITY OF IMMUNE CHECKPOINT MOLECULES
CN115197314B (zh) * 2021-04-11 2025-08-19 中国科学院分子细胞科学卓越创新中心 一种pd1变体及其用途
JP2024519945A (ja) * 2021-05-20 2024-05-21 アチェロイス バイオファーマ，インク． 免疫チェックポイント多価粒子の組成物、および使用方法
WO2023235479A1 (en) * 2022-06-02 2023-12-07 TCR2 Therapeutics Inc. Compositions and methods for treating cancer
WO2024107577A2 (en) * 2022-11-14 2024-05-23 Achelois Biopharma, Inc. Immune checkpoint multivalent particles compositions and methods of use
WO2025212859A1 (en) * 2024-04-03 2025-10-09 Solid Biosciences, Inc. Methods and constructs for increasing solid organ transplant survival

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19822115B4 (de) 1998-05-08 2004-04-08 Heinrich-Pette-Institut Retrovirale Gentransfervektoren
CN101287831B (zh) 2005-09-13 2013-05-15 国立大学法人三重大学 T细胞受体和编码该受体的核酸
WO2010012829A1 (en) 2008-07-31 2010-02-04 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Her2/neu specific t cell receptors
ZA200807283B (en) 2008-08-22 2009-10-28 Mechlift Invest Pty Ltd Data unit for a bin lifting device
JP5794917B2 (ja) 2008-09-12 2015-10-14 アイシス・イノベーション・リミテッドＩｓｉｓ Ｉｎｎｏｖａｔｉｏｎｌｉｍｉｔｅｄ Ｐｄ−１特異抗体およびその使用
MX342017B (es) * 2010-03-26 2016-09-09 Dartmouth College Proteina mediadora de celula t regulatoria vista, agentes de enlace de vista y uso de los mismos.
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
TR201815488T4 (tr) 2011-04-08 2018-11-21 Health Anti-epidermal büyüme faktör reseptörü varyant III kimerik antijen reseptörleri ve kanser tedavisi için kullanımı.
PH12014500247A1 (en) 2011-07-29 2014-03-24 Univ Pennsylvania Switch costimulatory receptors
IN2014CN02906A (enExample) 2011-10-20 2015-07-03 Us Health
US9688740B2 (en) * 2011-10-26 2017-06-27 National Cancer Center Mutant CTLA4 gene transfected T cell and composition including same for anticancer immunotherapy
WO2013062365A2 (ko) * 2011-10-26 2013-05-02 국립암센터 변이 ｃｔｌａ4 유전자 이입 ｔ 세포 및 이를 포함하는 항암 면역치료용 조성물
CA2868121C (en) 2012-03-23 2021-06-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mesothelin chimeric antigen receptors
ES3065694T3 (en) 2012-04-11 2026-05-07 Us Health Chimeric antigen receptors targeting b-cell maturation antigen
GB201206559D0 (en) 2012-04-13 2012-05-30 Ucl Business Plc Polypeptide
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
TWI654206B (zh) 2013-03-16 2019-03-21 諾華公司 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症
JP6285553B2 (ja) 2013-08-26 2018-02-28 インノバイオファーム リミテッド 抗ｃｄ３０キメラ抗原受容体およびその使用
HK1251862A1 (zh) 2014-12-02 2019-04-26 普拉斯派克特查特凯尔Rwmc有限责任公司 治疗癌症的方法和组合物
CN107531805A (zh) 2015-03-05 2018-01-02 弗雷德哈钦森癌症研究中心 免疫调节融合蛋白及其用途
CN115927474A (zh) 2015-06-19 2023-04-07 塞巴斯蒂安·科博尔德 Pd-1-cd28融合蛋白及其在医学中的用途
WO2016210129A1 (en) 2015-06-23 2016-12-29 Memorial Sloan-Kettering Cancer Center Novel pd-1 immune modulating agents
US20180185434A1 (en) 2015-06-29 2018-07-05 The Johns Hopkins University Immune checkpoint chimeric antigen receptors therapy
US11242375B2 (en) 2015-09-04 2022-02-08 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use
US11020429B2 (en) 2015-11-05 2021-06-01 Juno Therapeutics, Inc. Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
CN105331585A (zh) 2015-11-13 2016-02-17 科济生物医药（上海）有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
US11648268B2 (en) 2015-12-09 2023-05-16 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of using same
WO2017162797A1 (en) 2016-03-23 2017-09-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Fusion proteins of pd-1 and 4-1bb
JP2020512284A (ja) 2016-12-22 2020-04-23 ウィンドミル セラピューティクス インコーポレイテッド 免疫系調節組成物および方法
CA3071661A1 (en) 2017-09-06 2019-03-14 Fred Hutchinson Cancer Research Center Strep-tag specific chimeric receptors and uses thereof
CN115418362B (zh) * 2019-12-02 2025-06-13 吉林凯莱英医药化学有限公司 共固定化酶、其制备方法及其应用

Also Published As

Publication number Publication date
DK3310805T3 (da) 2021-05-03
PL3310805T3 (pl) 2021-08-23
CA2989949A1 (en) 2016-12-22
US11192935B2 (en) 2021-12-07
FI3909972T3 (fi) 2024-05-03
EP4349854A2 (en) 2024-04-10
EP3310805B1 (en) 2021-02-17
HUE054201T2 (hu) 2021-08-30
DK3909972T3 (da) 2024-04-29
CN115927474A (zh) 2023-04-07
CN108026151A (zh) 2018-05-11
JP7085988B2 (ja) 2022-06-17
EP3909972A1 (en) 2021-11-17
DK3909972T5 (da) 2024-08-05
JP2022084787A (ja) 2022-06-07
EP3909972B1 (en) 2024-02-14
US20190010207A1 (en) 2019-01-10
EP4349854A3 (en) 2024-07-10
CN115925971A (zh) 2023-04-07
US12570718B2 (en) 2026-03-10
US20220169699A1 (en) 2022-06-02
AU2016277883A8 (en) 2018-01-25
EP3310805A1 (en) 2018-04-25
JP2018518990A (ja) 2018-07-19
PT3310805T (pt) 2021-05-19
CN108026151B (zh) 2022-07-15
JP7460675B2 (ja) 2024-04-02
JP2024073636A (ja) 2024-05-29
AU2016277883A1 (en) 2018-01-18
WO2016203048A1 (en) 2016-12-22
AU2016277883B2 (en) 2020-09-17
ES2976647T3 (es) 2024-08-06

Similar Documents

Publication Publication Date Title
JP7460675B2 (ja) Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用
JP6612963B2 (ja) 腫瘍抗原を直接認識するために組換えｔ細胞レセプターを使用するための組成物及び方法
ES2841274T3 (es) Inmunoterapia con células T específica para WT-1
ES2962588T3 (es) Proteínas de fusión de PD-1 y 4-1BB
KR102830462B1 (ko) 인간 메소텔린을 특이적으로 인식하는 세포 표면 분자, il-7, 및 ccl19 를 발현하는 면역 담당 세포
EP3099708B1 (en) Methods and compositions for producing a cell expressing a t cell receptor
CN108424462A (zh) 使t细胞重定向针对cd70阳性恶性肿瘤的嵌合cd27受体
KR20240046644A (ko) 고형암을 위한 키메라 항원 수용체 및 키메라 항원 수용체가 발현된 t 세포
US12570714B2 (en) Siglec-based chimeric polypeptides and uses thereof
US20250108069A1 (en) Chimeric adaptor polypeptides
HK40064520B (en) Pd1-cd28 fusion proteins and their use in medicine
HK40064520A (en) Pd1-cd28 fusion proteins and their use in medicine
HK40109405A (en) Pd1-cd28 fusion proteins and their use in medicine
CN115151274A (zh) Hla限制性hormad1 t细胞受体及其用途