ES2860450T3 - Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante - Google Patents

Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante Download PDF

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Publication number
ES2860450T3
ES2860450T3 ES18173179T ES18173179T ES2860450T3 ES 2860450 T3 ES2860450 T3 ES 2860450T3 ES 18173179 T ES18173179 T ES 18173179T ES 18173179 T ES18173179 T ES 18173179T ES 2860450 T3 ES2860450 T3 ES 2860450T3
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ES
Spain
Prior art keywords
rvwf
fviii
composition
stability
administered
Prior art date
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Active
Application number
ES18173179T
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English (en)
Spanish (es)
Inventor
Friedrich Scheiflinger
Peter Turecek
Bruce Ewenstein
Wing Yen Wong
Tobias M Suiter
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of ES2860450T3 publication Critical patent/ES2860450T3/es
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
ES18173179T 2011-06-10 2012-06-11 Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante Active ES2860450T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161495884P 2011-06-10 2011-06-10
US201161511901P 2011-07-26 2011-07-26
US201161523790P 2011-08-15 2011-08-15

Publications (1)

Publication Number Publication Date
ES2860450T3 true ES2860450T3 (es) 2021-10-05

Family

ID=46321496

Family Applications (3)

Application Number Title Priority Date Filing Date
ES18173179T Active ES2860450T3 (es) 2011-06-10 2012-06-11 Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante
ES20216368T Active ES2976169T3 (es) 2011-06-10 2012-06-11 Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante
ES12728919.7T Active ES2682249T3 (es) 2011-06-10 2012-06-11 Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES20216368T Active ES2976169T3 (es) 2011-06-10 2012-06-11 Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante
ES12728919.7T Active ES2682249T3 (es) 2011-06-10 2012-06-11 Tratamiento de una enfermedad de la coagulación mediante la administración de VWF recombinante

Country Status (24)

Country Link
US (2) US9272021B2 (enExample)
EP (3) EP3858375B1 (enExample)
JP (3) JP6347468B2 (enExample)
KR (3) KR20190041032A (enExample)
CN (3) CN108210889A (enExample)
AR (1) AR086904A1 (enExample)
AU (5) AU2012267458A1 (enExample)
BR (1) BR112013031795A2 (enExample)
CA (1) CA2838845C (enExample)
DK (3) DK3412305T3 (enExample)
ES (3) ES2860450T3 (enExample)
FI (1) FI3858375T3 (enExample)
HK (1) HK1257436A1 (enExample)
HR (1) HRP20180962T1 (enExample)
HU (1) HUE039317T2 (enExample)
LT (1) LT2717905T (enExample)
MX (2) MX350582B (enExample)
PL (3) PL3858375T3 (enExample)
PT (3) PT2717905T (enExample)
RU (2) RU2680402C2 (enExample)
SG (2) SG10201604684WA (enExample)
SI (1) SI2717905T1 (enExample)
TR (1) TR201808823T4 (enExample)
WO (1) WO2012171031A1 (enExample)

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CN108210889A (zh) * 2011-06-10 2018-06-29 百深有限责任公司 通过施用重组vwf治疗凝血疾病
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FR3034669B1 (fr) 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation du facteur von willebrand
SG11201808475XA (en) 2016-04-15 2018-10-30 Baxalta Inc Method and apparatus for providing a pharmacokinetic drug dosing regiment
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US10632176B2 (en) 2017-07-07 2020-04-28 Baxalta Incorporated Treatment of gastrointestinal bleeding in patients with severe von Willebrand disease by administration of recombinant VWF
MY204220A (en) 2018-02-06 2024-08-16 Ablynx Nv Methods of treating initial episode of ttp with immunoglobulin single variable domains
MX2020009788A (es) * 2018-03-21 2020-12-09 Takeda Pharmaceuticals Co Separación de factor de von willebrand (vwf) y propéptido de factor de von willebrand (vwf) por métodos cromatográficos.
KR20210134642A (ko) * 2019-02-01 2021-11-10 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf (rvwf)를 이용한 예방 치료 방법
US20220401524A1 (en) * 2019-09-11 2022-12-22 Takeda Pharmaceutical Company Limited Methods of treatment related to complexes of von willebrand factor and complement c1q
AR121268A1 (es) 2020-02-04 2022-05-04 Takeda Pharmaceuticals Co Tratamiento de la menorragia en pacientes con enfermedad de von willebrand grave mediante la administración de vwf recombinante
IL303089A (en) * 2020-11-24 2023-07-01 Band Therapeutics Llc Compositions and methods for treatment of bleeding disorders
WO2024124136A1 (en) * 2022-12-09 2024-06-13 Vega Therapeutics, Inc. Von willebrand disease animal models

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BRPI0820271A2 (pt) 2007-11-09 2015-05-26 Baxter Int Métodos de aumentar a sobrevivência de uma proteína de coagulação pela inibição da interação com um receptor de depuração, de aumentar a sobrevivência de fator viii que inibe receptores de depruração de proteína de coagulação, de tratar um indivíduo com uma doença de coagulação sanguínea, e de tratar uma doença que tem por característica uma deficiência de fator viii em um indivíduo, e, proteína de ...métodos de aumentar a sobrevivência de uma proteína de coagulação pela inibição da interação com um receptor de depuração, de aumentar a sobrevivência de fator viii pela inibição da interação com um receptor de depuração, de preparar uma composição que inibe receptores de depuração de proteína de coagulação, de tratar um indivíduo com uma doença de coagulação sanguínea, e de tratar uma doença que tem por característica uma deficiência de fator viii em um indivíduo, e, proteína de coagulação modificada.
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Also Published As

Publication number Publication date
EP3858375A1 (en) 2021-08-04
HRP20180962T1 (hr) 2018-10-19
RU2014100107A (ru) 2015-07-20
DK3858375T3 (da) 2024-04-15
JP2017019788A (ja) 2017-01-26
KR20200091476A (ko) 2020-07-30
ES2976169T3 (es) 2024-07-24
EP3858375B1 (en) 2024-03-20
PL3412305T3 (pl) 2021-05-31
LT2717905T (lt) 2018-10-10
CA2838845C (en) 2019-08-06
PT3412305T (pt) 2021-01-29
RU2017102679A3 (enExample) 2018-12-19
RU2017102679A (ru) 2018-12-19
FI3858375T3 (fi) 2024-04-17
TR201808823T4 (tr) 2018-07-23
SI2717905T1 (sl) 2018-09-28
EP3412305A1 (en) 2018-12-12
HK1257436A1 (zh) 2019-10-18
NZ618790A (en) 2015-07-31
RU2019103386A (ru) 2020-08-07
KR20140039285A (ko) 2014-04-01
HUE039317T2 (hu) 2018-12-28
ES2682249T3 (es) 2018-09-19
AU2012267458A1 (en) 2014-01-09
KR101969515B1 (ko) 2019-04-16
PL3858375T3 (pl) 2024-05-20
MX2013014543A (es) 2014-06-11
KR20190041032A (ko) 2019-04-19
EP3412305B1 (en) 2021-01-06
AU2022201518B2 (en) 2025-07-03
AU2017206235B2 (en) 2019-10-17
AU2016202299B2 (en) 2017-07-20
SG10202002591QA (en) 2020-05-28
MX350582B (es) 2017-09-11
US20160184403A1 (en) 2016-06-30
US20120316116A1 (en) 2012-12-13
RU2680402C2 (ru) 2019-02-21
JP6347468B2 (ja) 2018-06-27
CN107412743B (zh) 2021-07-02
CN108210889A (zh) 2018-06-29
KR102319868B1 (ko) 2021-11-01
MX2020000083A (es) 2020-08-06
PT3858375T (pt) 2024-04-18
JP2019048892A (ja) 2019-03-28
EP2717905A1 (en) 2014-04-16
CN107412743A (zh) 2017-12-01
JP6527114B2 (ja) 2019-06-05
AU2020200026A1 (en) 2020-01-30
PT2717905T (pt) 2018-07-02
JP2014516088A (ja) 2014-07-07
RU2628537C2 (ru) 2017-08-18
DK3412305T3 (da) 2021-03-01
US9272021B2 (en) 2016-03-01
AU2017206235A1 (en) 2017-08-03
RU2019103386A3 (enExample) 2022-01-24
CN103732244A (zh) 2014-04-16
AU2022201518A1 (en) 2022-03-24
BR112013031795A2 (pt) 2016-12-20
AU2016202299A1 (en) 2016-05-05
SG10201604684WA (en) 2016-07-28
AR086904A1 (es) 2014-01-29
WO2012171031A1 (en) 2012-12-13
PL2717905T3 (pl) 2018-10-31
CA2838845A1 (en) 2012-12-13
DK2717905T3 (en) 2018-07-02
EP2717905B1 (en) 2018-05-23

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