CN108210889A - 通过施用重组vwf治疗凝血疾病 - Google Patents

通过施用重组vwf治疗凝血疾病 Download PDF

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Publication number
CN108210889A
CN108210889A CN201810079423.5A CN201810079423A CN108210889A CN 108210889 A CN108210889 A CN 108210889A CN 201810079423 A CN201810079423 A CN 201810079423A CN 108210889 A CN108210889 A CN 108210889A
Authority
CN
China
Prior art keywords
rvwf
fviii
composition
administered
rfviii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810079423.5A
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English (en)
Chinese (zh)
Inventor
F·沙伊芙林格
P·图雷切克
B·埃文斯汀
Y·W·王
M·T·休特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Hundred Deep Co
Hundred Deep LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hundred Deep Co, Hundred Deep LLC filed Critical Hundred Deep Co
Publication of CN108210889A publication Critical patent/CN108210889A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN201810079423.5A 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病 Pending CN108210889A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161495884P 2011-06-10 2011-06-10
US61/495,884 2011-06-10
US201161511901P 2011-07-26 2011-07-26
US61/511,901 2011-07-26
US201161523790P 2011-08-15 2011-08-15
US61/523,790 2011-08-15
CN201280038870.7A CN103732244A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280038870.7A Division CN103732244A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病

Publications (1)

Publication Number Publication Date
CN108210889A true CN108210889A (zh) 2018-06-29

Family

ID=46321496

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201810079423.5A Pending CN108210889A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病
CN201280038870.7A Pending CN103732244A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病
CN201611071108.5A Active CN107412743B (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201280038870.7A Pending CN103732244A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病
CN201611071108.5A Active CN107412743B (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病

Country Status (24)

Country Link
US (2) US9272021B2 (enExample)
EP (3) EP3858375B1 (enExample)
JP (3) JP6347468B2 (enExample)
KR (3) KR20190041032A (enExample)
CN (3) CN108210889A (enExample)
AR (1) AR086904A1 (enExample)
AU (5) AU2012267458A1 (enExample)
BR (1) BR112013031795A2 (enExample)
CA (1) CA2838845C (enExample)
DK (3) DK3412305T3 (enExample)
ES (3) ES2860450T3 (enExample)
FI (1) FI3858375T3 (enExample)
HK (1) HK1257436A1 (enExample)
HR (1) HRP20180962T1 (enExample)
HU (1) HUE039317T2 (enExample)
LT (1) LT2717905T (enExample)
MX (2) MX350582B (enExample)
PL (3) PL3858375T3 (enExample)
PT (3) PT2717905T (enExample)
RU (2) RU2680402C2 (enExample)
SG (2) SG10201604684WA (enExample)
SI (1) SI2717905T1 (enExample)
TR (1) TR201808823T4 (enExample)
WO (1) WO2012171031A1 (enExample)

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CN108210889A (zh) * 2011-06-10 2018-06-29 百深有限责任公司 通过施用重组vwf治疗凝血疾病
CN102776260B (zh) * 2012-07-26 2015-04-29 上海泰龙生物医药科技有限公司 一种高效表达重组人凝血八因子的方法
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NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
FR3034669B1 (fr) 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation du facteur von willebrand
SG11201808475XA (en) 2016-04-15 2018-10-30 Baxalta Inc Method and apparatus for providing a pharmacokinetic drug dosing regiment
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
AU2018298232B2 (en) * 2017-07-07 2025-04-03 Takeda Pharmaceutical Company Limited Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant VWF
US10632176B2 (en) 2017-07-07 2020-04-28 Baxalta Incorporated Treatment of gastrointestinal bleeding in patients with severe von Willebrand disease by administration of recombinant VWF
MY204220A (en) 2018-02-06 2024-08-16 Ablynx Nv Methods of treating initial episode of ttp with immunoglobulin single variable domains
MX2020009788A (es) * 2018-03-21 2020-12-09 Takeda Pharmaceuticals Co Separación de factor de von willebrand (vwf) y propéptido de factor de von willebrand (vwf) por métodos cromatográficos.
KR20210134642A (ko) * 2019-02-01 2021-11-10 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf (rvwf)를 이용한 예방 치료 방법
US20220401524A1 (en) * 2019-09-11 2022-12-22 Takeda Pharmaceutical Company Limited Methods of treatment related to complexes of von willebrand factor and complement c1q
AR121268A1 (es) 2020-02-04 2022-05-04 Takeda Pharmaceuticals Co Tratamiento de la menorragia en pacientes con enfermedad de von willebrand grave mediante la administración de vwf recombinante
IL303089A (en) * 2020-11-24 2023-07-01 Band Therapeutics Llc Compositions and methods for treatment of bleeding disorders
WO2024124136A1 (en) * 2022-12-09 2024-06-13 Vega Therapeutics, Inc. Von willebrand disease animal models

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Publication number Publication date
EP3858375A1 (en) 2021-08-04
HRP20180962T1 (hr) 2018-10-19
RU2014100107A (ru) 2015-07-20
DK3858375T3 (da) 2024-04-15
JP2017019788A (ja) 2017-01-26
KR20200091476A (ko) 2020-07-30
ES2976169T3 (es) 2024-07-24
EP3858375B1 (en) 2024-03-20
PL3412305T3 (pl) 2021-05-31
LT2717905T (lt) 2018-10-10
CA2838845C (en) 2019-08-06
PT3412305T (pt) 2021-01-29
RU2017102679A3 (enExample) 2018-12-19
RU2017102679A (ru) 2018-12-19
FI3858375T3 (fi) 2024-04-17
TR201808823T4 (tr) 2018-07-23
SI2717905T1 (sl) 2018-09-28
EP3412305A1 (en) 2018-12-12
HK1257436A1 (zh) 2019-10-18
NZ618790A (en) 2015-07-31
RU2019103386A (ru) 2020-08-07
KR20140039285A (ko) 2014-04-01
HUE039317T2 (hu) 2018-12-28
ES2682249T3 (es) 2018-09-19
AU2012267458A1 (en) 2014-01-09
KR101969515B1 (ko) 2019-04-16
PL3858375T3 (pl) 2024-05-20
MX2013014543A (es) 2014-06-11
KR20190041032A (ko) 2019-04-19
EP3412305B1 (en) 2021-01-06
AU2022201518B2 (en) 2025-07-03
AU2017206235B2 (en) 2019-10-17
AU2016202299B2 (en) 2017-07-20
SG10202002591QA (en) 2020-05-28
MX350582B (es) 2017-09-11
US20160184403A1 (en) 2016-06-30
US20120316116A1 (en) 2012-12-13
RU2680402C2 (ru) 2019-02-21
JP6347468B2 (ja) 2018-06-27
CN107412743B (zh) 2021-07-02
ES2860450T3 (es) 2021-10-05
KR102319868B1 (ko) 2021-11-01
MX2020000083A (es) 2020-08-06
PT3858375T (pt) 2024-04-18
JP2019048892A (ja) 2019-03-28
EP2717905A1 (en) 2014-04-16
CN107412743A (zh) 2017-12-01
JP6527114B2 (ja) 2019-06-05
AU2020200026A1 (en) 2020-01-30
PT2717905T (pt) 2018-07-02
JP2014516088A (ja) 2014-07-07
RU2628537C2 (ru) 2017-08-18
DK3412305T3 (da) 2021-03-01
US9272021B2 (en) 2016-03-01
AU2017206235A1 (en) 2017-08-03
RU2019103386A3 (enExample) 2022-01-24
CN103732244A (zh) 2014-04-16
AU2022201518A1 (en) 2022-03-24
BR112013031795A2 (pt) 2016-12-20
AU2016202299A1 (en) 2016-05-05
SG10201604684WA (en) 2016-07-28
AR086904A1 (es) 2014-01-29
WO2012171031A1 (en) 2012-12-13
PL2717905T3 (pl) 2018-10-31
CA2838845A1 (en) 2012-12-13
DK2717905T3 (en) 2018-07-02
EP2717905B1 (en) 2018-05-23

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