ES2824452T3 - Métodos para producir coloides de hidroxido de hierro férrico modificados con un ligando de carboxilato y composiciones y usos relacionados - Google Patents
Métodos para producir coloides de hidroxido de hierro férrico modificados con un ligando de carboxilato y composiciones y usos relacionados Download PDFInfo
- Publication number
- ES2824452T3 ES2824452T3 ES16778044T ES16778044T ES2824452T3 ES 2824452 T3 ES2824452 T3 ES 2824452T3 ES 16778044 T ES16778044 T ES 16778044T ES 16778044 T ES16778044 T ES 16778044T ES 2824452 T3 ES2824452 T3 ES 2824452T3
- Authority
- ES
- Spain
- Prior art keywords
- ferric iron
- modified
- ligand
- carboxylate
- iron hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000014413 iron hydroxide Nutrition 0.000 title claims abstract 36
- 239000000203 mixture Substances 0.000 title claims abstract 14
- 238000000034 method Methods 0.000 title claims 18
- -1 Carboxylate Ligand-Modified Ferric Iron Chemical class 0.000 title claims 5
- 239000000084 colloidal system Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 claims abstract 58
- 150000007942 carboxylates Chemical class 0.000 claims abstract 42
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical class [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims abstract 41
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims abstract 31
- 238000009472 formulation Methods 0.000 claims abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 5
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract 5
- 239000002904 solvent Substances 0.000 claims abstract 5
- 239000000725 suspension Substances 0.000 claims abstract 5
- 238000001035 drying Methods 0.000 claims abstract 3
- 239000007790 solid phase Substances 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 19
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 11
- 229940095064 tartrate Drugs 0.000 claims 10
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 8
- 229910052742 iron Inorganic materials 0.000 claims 8
- 239000000463 material Substances 0.000 claims 8
- 239000002775 capsule Substances 0.000 claims 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 5
- 239000003826 tablet Substances 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 239000013589 supplement Substances 0.000 claims 4
- 206010022971 Iron Deficiencies Diseases 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 208000030760 Anaemia of chronic disease Diseases 0.000 claims 1
- 208000017667 Chronic Disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 208000022400 anemia due to chronic disease Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000006651 lactation Effects 0.000 claims 1
- 238000003801 milling Methods 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A23L33/165—Complexes or chelates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Iron (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1517893.2A GB201517893D0 (en) | 2015-10-09 | 2015-10-09 | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids |
| PCT/EP2016/074022 WO2017060441A1 (en) | 2015-10-09 | 2016-10-07 | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids and related compositions and uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2824452T3 true ES2824452T3 (es) | 2021-05-12 |
Family
ID=55130824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16778044T Active ES2824452T3 (es) | 2015-10-09 | 2016-10-07 | Métodos para producir coloides de hidroxido de hierro férrico modificados con un ligando de carboxilato y composiciones y usos relacionados |
Country Status (19)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11560339B2 (en) | 2019-05-30 | 2023-01-24 | Koch Agronomie Services, LLC | Micronutrient foliar solutions |
| GB202005054D0 (en) | 2020-04-06 | 2020-05-20 | Nemysis Ltd | Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases |
| CN115196684B (zh) * | 2022-07-25 | 2024-10-01 | 武汉海斯普林科技发展有限公司 | 一种高活性高纯氢氧化铁、制备方法及在合成对甲基苯磺酸铁中的应用 |
| WO2026017897A1 (en) | 2024-07-18 | 2026-01-22 | Malian Biologicals Gmbh | Iron supplementation in affective disorders and/or post-traumatic stress disorder (ptsd) and/or serotonin-dependent diseases |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3076798A (en) | 1961-02-23 | 1963-02-05 | Hausmann Lab Ltd | Process for preparing a ferric hydroxide polymaltose complex |
| US3821192A (en) | 1971-08-18 | 1974-06-28 | Central Pharmacal Co | Process for preparing an iron-saccharide complex |
| CN1124757A (zh) * | 1994-12-31 | 1996-06-19 | 温固 | 速溶多羟基混合金属盐正电固溶胶制备方法 |
| CN1121349C (zh) * | 2001-10-30 | 2003-09-17 | 李国栋 | 一种无团聚氧化锌纳米粉体制造方法 |
| US7994217B2 (en) | 2002-05-02 | 2011-08-09 | Xanodyne Pharmaceuticals, Inc. | Prenatal multivitamin/multimineral supplement |
| GB0211500D0 (en) | 2002-05-18 | 2002-06-26 | Vitra Pharmaceuticals Ltd | Method of forming iron hydroxypyrone compounds |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| TWI335218B (en) * | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| US8093423B2 (en) | 2003-02-19 | 2012-01-10 | Globoasia, Llc | Pharmaceutical-grade ferric organic compounds, uses thereof and method of making same |
| US7964568B2 (en) | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| US7179939B2 (en) | 2004-03-16 | 2007-02-20 | Navinta Llc | Sodium ferric gluconate complexes and method of manufacture thereof |
| AU2004319676B2 (en) | 2004-05-17 | 2011-01-06 | Cilag Ag | Method for producing iron (III) gluconate complex |
| BRPI0515847A (pt) | 2004-10-08 | 2008-08-12 | Unilever Nv | uso de um complexo de ferro, composição alimentìcia, gênero alimentìcio fortificado com ferro, composição de bebida, bebida fortificada com ferro, suplemento alimentar e composição farmacêutica |
| GB0702270D0 (en) * | 2007-02-06 | 2007-03-14 | Medical Res Council | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| EP2125847B1 (en) * | 2007-02-06 | 2015-06-17 | Medical Research Council | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| GB0814326D0 (en) | 2008-08-05 | 2008-09-10 | Medical Res Council | Phosphate binding materials and their uses |
| CN101691485B (zh) * | 2009-07-29 | 2012-03-28 | 西南石油大学 | 钻井液用抗高温两性离子聚合物降滤失剂及其制备方法 |
| CN103272553B (zh) * | 2013-05-16 | 2015-05-13 | 武汉大学 | 一种用于除去水体中砷的磁性纳米氧化铁吸附剂的制备方法 |
| CN103626807B (zh) * | 2013-11-20 | 2017-07-07 | 青岛国风药业股份有限公司 | 一种多糖铁复合物的制备方法及其质量检测方法 |
| CN103848989B (zh) * | 2014-03-20 | 2016-06-08 | 南京大学 | 一种镍锌铁氧体/聚苯胺复合材料的制备方法 |
| JP6508487B2 (ja) * | 2014-05-23 | 2019-05-08 | 戸田工業株式会社 | ヘマタイト粒子粉末の製造方法、該ヘマタイト粒子粉末を用いた塗料の製造方法及び樹脂組成物の製造方法 |
-
2015
- 2015-10-09 GB GBGB1517893.2A patent/GB201517893D0/en not_active Ceased
-
2016
- 2016-10-07 ES ES16778044T patent/ES2824452T3/es active Active
- 2016-10-07 EA EA201890601A patent/EA035547B1/ru unknown
- 2016-10-07 CN CN201680058940.3A patent/CN108430964B/zh active Active
- 2016-10-07 WO PCT/EP2016/074022 patent/WO2017060441A1/en not_active Ceased
- 2016-10-07 AU AU2016333725A patent/AU2016333725B2/en active Active
- 2016-10-07 HU HUE16778044A patent/HUE051502T2/hu unknown
- 2016-10-07 SI SI201630967T patent/SI3359519T1/sl unknown
- 2016-10-07 JP JP2018517847A patent/JP7008624B2/ja active Active
- 2016-10-07 PL PL16778044T patent/PL3359519T3/pl unknown
- 2016-10-07 EP EP16778044.4A patent/EP3359519B1/en active Active
- 2016-10-07 US US15/765,367 patent/US10722459B2/en active Active
- 2016-10-07 SG SG11201802770WA patent/SG11201802770WA/en unknown
- 2016-10-07 PT PT167780444T patent/PT3359519T/pt unknown
- 2016-10-07 BR BR112018007098-0A patent/BR112018007098B1/pt active IP Right Grant
- 2016-10-07 MX MX2018004113A patent/MX2018004113A/es unknown
- 2016-10-07 DK DK16778044.4T patent/DK3359519T3/da active
- 2016-10-07 CA CA3000589A patent/CA3000589C/en active Active
-
2018
- 2018-04-04 ZA ZA2018/02192A patent/ZA201802192B/en unknown
-
2020
- 2020-01-21 US US16/747,821 patent/US11684572B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201802192B (en) | 2020-09-30 |
| AU2016333725A1 (en) | 2018-04-26 |
| BR112018007098A2 (pt) | 2019-01-15 |
| US10722459B2 (en) | 2020-07-28 |
| SG11201802770WA (en) | 2018-05-30 |
| US11684572B2 (en) | 2023-06-27 |
| US20200155453A1 (en) | 2020-05-21 |
| HUE051502T2 (hu) | 2021-03-01 |
| GB201517893D0 (en) | 2015-11-25 |
| HK1253078A1 (en) | 2019-06-06 |
| EA035547B1 (ru) | 2020-07-06 |
| PL3359519T3 (pl) | 2021-03-08 |
| CA3000589A1 (en) | 2017-04-13 |
| CN108430964A (zh) | 2018-08-21 |
| PT3359519T (pt) | 2020-10-13 |
| BR112018007098B1 (pt) | 2023-10-10 |
| EP3359519A1 (en) | 2018-08-15 |
| CA3000589C (en) | 2024-01-09 |
| DK3359519T3 (da) | 2020-09-07 |
| SI3359519T1 (sl) | 2021-03-31 |
| US20180271784A1 (en) | 2018-09-27 |
| EP3359519B1 (en) | 2020-08-12 |
| JP2018530565A (ja) | 2018-10-18 |
| EA201890601A1 (ru) | 2018-11-30 |
| AU2016333725B2 (en) | 2020-10-22 |
| WO2017060441A1 (en) | 2017-04-13 |
| JP7008624B2 (ja) | 2022-01-25 |
| CN108430964B (zh) | 2021-05-11 |
| MX2018004113A (es) | 2018-05-17 |
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