EA035547B1 - Способы получения коллоидных частиц гидроксида железа (iii), модифицированного карбоксилатным лигандом, содержащие их композиции и способы применения - Google Patents
Способы получения коллоидных частиц гидроксида железа (iii), модифицированного карбоксилатным лигандом, содержащие их композиции и способы применения Download PDFInfo
- Publication number
- EA035547B1 EA035547B1 EA201890601A EA201890601A EA035547B1 EA 035547 B1 EA035547 B1 EA 035547B1 EA 201890601 A EA201890601 A EA 201890601A EA 201890601 A EA201890601 A EA 201890601A EA 035547 B1 EA035547 B1 EA 035547B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- iron
- iii
- carboxylate ligand
- hydroxide
- ligand
- Prior art date
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- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 description 1
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- 150000001721 carbon Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
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- 230000004700 cellular uptake Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
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- 238000002447 crystallographic data Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
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- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000002003 electron diffraction Methods 0.000 description 1
- 238000005430 electron energy loss spectroscopy Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000010437 erythropoiesis Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000011706 ferric diphosphate Substances 0.000 description 1
- 235000007144 ferric diphosphate Nutrition 0.000 description 1
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 description 1
- 229940042644 ferrlecit Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 1
- 235000021472 generally recognized as safe Nutrition 0.000 description 1
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 238000002173 high-resolution transmission electron microscopy Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 238000009616 inductively coupled plasma Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- PKMVWNYIYVZXIQ-MPAYLTKRSA-K iron(3+);(2r,3s,4r,5r)-2,3,4,5-tetrahydroxy-6-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanal;trihydroxide Chemical compound [OH-].[OH-].[OH-].[Fe+3].OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@H](O)[C@@H](O)[C@@H]1O PKMVWNYIYVZXIQ-MPAYLTKRSA-K 0.000 description 1
- LIKBJVNGSGBSGK-UHFFFAOYSA-N iron(3+);oxygen(2-) Chemical group [O-2].[O-2].[O-2].[Fe+3].[Fe+3] LIKBJVNGSGBSGK-UHFFFAOYSA-N 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
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- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002707 nanocrystalline material Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
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- 239000008188 pellet Substances 0.000 description 1
- 238000004940 physical analysis method Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008741 proinflammatory signaling process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001350 scanning transmission electron microscopy Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- KYKFCSHPTAVNJD-UHFFFAOYSA-L sodium adipate Chemical compound [Na+].[Na+].[O-]C(=O)CCCCC([O-])=O KYKFCSHPTAVNJD-UHFFFAOYSA-L 0.000 description 1
- 239000001601 sodium adipate Substances 0.000 description 1
- 235000011049 sodium adipate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- MQBDAEHWGRMADS-XNHLMZCASA-M sodium;(2r,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;iron(3+);oxygen(2-);(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [O-2].[O-2].[O-2].[Na+].[Fe+3].[Fe+3].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1.O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1.O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1.O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1.O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 MQBDAEHWGRMADS-XNHLMZCASA-M 0.000 description 1
- VAVPGQSSOJBZIP-UHFFFAOYSA-N sodium;iron(3+) Chemical compound [Na+].[Fe+3] VAVPGQSSOJBZIP-UHFFFAOYSA-N 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
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- 239000002195 soluble material Substances 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
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- 229940015977 teferrol Drugs 0.000 description 1
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- JSPLKZUTYZBBKA-UHFFFAOYSA-N trioxidane Chemical compound OOO JSPLKZUTYZBBKA-UHFFFAOYSA-N 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A23L33/165—Complexes or chelates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Iron (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1517893.2A GB201517893D0 (en) | 2015-10-09 | 2015-10-09 | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids |
| PCT/EP2016/074022 WO2017060441A1 (en) | 2015-10-09 | 2016-10-07 | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids and related compositions and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201890601A1 EA201890601A1 (ru) | 2018-11-30 |
| EA035547B1 true EA035547B1 (ru) | 2020-07-06 |
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| EA201890601A EA035547B1 (ru) | 2015-10-09 | 2016-10-07 | Способы получения коллоидных частиц гидроксида железа (iii), модифицированного карбоксилатным лигандом, содержащие их композиции и способы применения |
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| US11560339B2 (en) | 2019-05-30 | 2023-01-24 | Koch Agronomie Services, LLC | Micronutrient foliar solutions |
| GB202005054D0 (en) | 2020-04-06 | 2020-05-20 | Nemysis Ltd | Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases |
| CN115196684B (zh) * | 2022-07-25 | 2024-10-01 | 武汉海斯普林科技发展有限公司 | 一种高活性高纯氢氧化铁、制备方法及在合成对甲基苯磺酸铁中的应用 |
| WO2026017897A1 (en) | 2024-07-18 | 2026-01-22 | Malian Biologicals Gmbh | Iron supplementation in affective disorders and/or post-traumatic stress disorder (ptsd) and/or serotonin-dependent diseases |
Citations (3)
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| US20080188555A1 (en) * | 2007-02-06 | 2008-08-07 | Jonathan Joseph Powell | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| US20100032374A1 (en) * | 2008-08-05 | 2010-02-11 | Medical Research Council | Phosphate binding materials and their uses |
| WO2015178451A1 (ja) * | 2014-05-23 | 2015-11-26 | 戸田工業株式会社 | ヘマタイト粒子粉末の製造方法、該ヘマタイト粒子粉末を用いた塗料及び樹脂組成物 |
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|---|---|---|---|---|
| US3076798A (en) | 1961-02-23 | 1963-02-05 | Hausmann Lab Ltd | Process for preparing a ferric hydroxide polymaltose complex |
| US3821192A (en) | 1971-08-18 | 1974-06-28 | Central Pharmacal Co | Process for preparing an iron-saccharide complex |
| CN1124757A (zh) * | 1994-12-31 | 1996-06-19 | 温固 | 速溶多羟基混合金属盐正电固溶胶制备方法 |
| CN1121349C (zh) * | 2001-10-30 | 2003-09-17 | 李国栋 | 一种无团聚氧化锌纳米粉体制造方法 |
| US7994217B2 (en) | 2002-05-02 | 2011-08-09 | Xanodyne Pharmaceuticals, Inc. | Prenatal multivitamin/multimineral supplement |
| GB0211500D0 (en) | 2002-05-18 | 2002-06-26 | Vitra Pharmaceuticals Ltd | Method of forming iron hydroxypyrone compounds |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| TWI335218B (en) * | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| US8093423B2 (en) | 2003-02-19 | 2012-01-10 | Globoasia, Llc | Pharmaceutical-grade ferric organic compounds, uses thereof and method of making same |
| US7964568B2 (en) | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| US7179939B2 (en) | 2004-03-16 | 2007-02-20 | Navinta Llc | Sodium ferric gluconate complexes and method of manufacture thereof |
| AU2004319676B2 (en) | 2004-05-17 | 2011-01-06 | Cilag Ag | Method for producing iron (III) gluconate complex |
| BRPI0515847A (pt) | 2004-10-08 | 2008-08-12 | Unilever Nv | uso de um complexo de ferro, composição alimentìcia, gênero alimentìcio fortificado com ferro, composição de bebida, bebida fortificada com ferro, suplemento alimentar e composição farmacêutica |
| GB0702270D0 (en) * | 2007-02-06 | 2007-03-14 | Medical Res Council | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| CN101691485B (zh) * | 2009-07-29 | 2012-03-28 | 西南石油大学 | 钻井液用抗高温两性离子聚合物降滤失剂及其制备方法 |
| CN103272553B (zh) * | 2013-05-16 | 2015-05-13 | 武汉大学 | 一种用于除去水体中砷的磁性纳米氧化铁吸附剂的制备方法 |
| CN103626807B (zh) * | 2013-11-20 | 2017-07-07 | 青岛国风药业股份有限公司 | 一种多糖铁复合物的制备方法及其质量检测方法 |
| CN103848989B (zh) * | 2014-03-20 | 2016-06-08 | 南京大学 | 一种镍锌铁氧体/聚苯胺复合材料的制备方法 |
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| US20080188555A1 (en) * | 2007-02-06 | 2008-08-07 | Jonathan Joseph Powell | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| US20100032374A1 (en) * | 2008-08-05 | 2010-02-11 | Medical Research Council | Phosphate binding materials and their uses |
| WO2015178451A1 (ja) * | 2014-05-23 | 2015-11-26 | 戸田工業株式会社 | ヘマタイト粒子粉末の製造方法、該ヘマタイト粒子粉末を用いた塗料及び樹脂組成物 |
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| ZA201802192B (en) | 2020-09-30 |
| AU2016333725A1 (en) | 2018-04-26 |
| BR112018007098A2 (pt) | 2019-01-15 |
| US10722459B2 (en) | 2020-07-28 |
| SG11201802770WA (en) | 2018-05-30 |
| US11684572B2 (en) | 2023-06-27 |
| US20200155453A1 (en) | 2020-05-21 |
| ES2824452T3 (es) | 2021-05-12 |
| HUE051502T2 (hu) | 2021-03-01 |
| GB201517893D0 (en) | 2015-11-25 |
| HK1253078A1 (en) | 2019-06-06 |
| PL3359519T3 (pl) | 2021-03-08 |
| CA3000589A1 (en) | 2017-04-13 |
| CN108430964A (zh) | 2018-08-21 |
| PT3359519T (pt) | 2020-10-13 |
| BR112018007098B1 (pt) | 2023-10-10 |
| EP3359519A1 (en) | 2018-08-15 |
| CA3000589C (en) | 2024-01-09 |
| DK3359519T3 (da) | 2020-09-07 |
| SI3359519T1 (sl) | 2021-03-31 |
| US20180271784A1 (en) | 2018-09-27 |
| EP3359519B1 (en) | 2020-08-12 |
| JP2018530565A (ja) | 2018-10-18 |
| EA201890601A1 (ru) | 2018-11-30 |
| AU2016333725B2 (en) | 2020-10-22 |
| WO2017060441A1 (en) | 2017-04-13 |
| JP7008624B2 (ja) | 2022-01-25 |
| CN108430964B (zh) | 2021-05-11 |
| MX2018004113A (es) | 2018-05-17 |
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