ES2779990T3 - Reducción de la motilidad de células cancerosas utilizando campos de tratamiento de tumores (TTFIELDS) - Google Patents
Reducción de la motilidad de células cancerosas utilizando campos de tratamiento de tumores (TTFIELDS) Download PDFInfo
- Publication number
- ES2779990T3 ES2779990T3 ES17716642T ES17716642T ES2779990T3 ES 2779990 T3 ES2779990 T3 ES 2779990T3 ES 17716642 T ES17716642 T ES 17716642T ES 17716642 T ES17716642 T ES 17716642T ES 2779990 T3 ES2779990 T3 ES 2779990T3
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Classifications
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Program-control systems
- G05B19/02—Program-control systems electric
- G05B19/04—Program control other than numerical control, i.e. in sequence controllers or logic controllers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- Electrotherapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317985P | 2016-04-04 | 2016-04-04 | |
| PCT/IB2017/051898 WO2017175116A1 (en) | 2016-04-04 | 2017-04-04 | Reducing motility of cancer cells using tumor treating fields (ttfields) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2779990T3 true ES2779990T3 (es) | 2020-08-21 |
Family
ID=58530601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17716642T Active ES2779990T3 (es) | 2016-04-04 | 2017-04-04 | Reducción de la motilidad de células cancerosas utilizando campos de tratamiento de tumores (TTFIELDS) |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10821283B2 (enExample) |
| EP (3) | EP4234005B1 (enExample) |
| JP (2) | JP6896839B2 (enExample) |
| KR (1) | KR102430229B1 (enExample) |
| CN (2) | CN109475735B (enExample) |
| DK (1) | DK3439733T3 (enExample) |
| ES (1) | ES2779990T3 (enExample) |
| HU (1) | HUE048646T2 (enExample) |
| PL (1) | PL3439733T3 (enExample) |
| PT (1) | PT3439733T (enExample) |
| WO (1) | WO2017175116A1 (enExample) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| DK3474760T3 (da) | 2016-06-27 | 2023-03-20 | Galvanize Therapeutics Inc | Generator og et kateter med en elektrode til at behandle en lungepassage |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| EP3478360B1 (en) | 2016-06-30 | 2024-04-10 | Novocure GmbH | Arrays for longitudinal delivery of ttfields to a body |
| EP3571503B1 (en) | 2017-01-19 | 2026-04-15 | Novocure GmbH | System for viewing cell cultures under a microscope whilst applying ttfields |
| US12649056B2 (en) * | 2017-10-23 | 2026-06-09 | Cardiac Pacemakers, Inc. | Medical devices for treatment of cancer with electric fields |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US12403306B2 (en) * | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US20200368525A1 (en) * | 2017-11-17 | 2020-11-26 | Abbvie Inc. | Methods of Treating Glioblastoma |
| EP4552592A3 (en) | 2017-12-26 | 2025-06-18 | Galvanize Therapeutics, Inc. | Optimization of energy delivery for various applications |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| CN112566665A (zh) | 2018-04-09 | 2021-03-26 | 莫舍·吉拉迪 | 用TTFields和Aurora激酶抑制剂治疗肿瘤 |
| US11650277B2 (en) | 2018-04-10 | 2023-05-16 | Novocure Gmbh | TTField treatment with optimization of electrode positions based on low frequency (<1MHZ) AC conductivity estimates derived from two MRI images having different repetition times |
| KR102870236B1 (ko) * | 2018-07-03 | 2025-10-14 | 에드윈 창 | 세포막 투과성을 향상시키기 위한 교류 전기장 사용 |
| NZ770868A (en) * | 2018-07-10 | 2023-12-22 | Novocure Gmbh | Inhibiting viral infection using alternating electric fields |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| IL279253B2 (en) | 2018-07-18 | 2025-09-01 | Novocure Gmbh | Using power loss density and related measurements to quantify dose of tumor treatment fields |
| MX2020013519A (es) * | 2018-08-23 | 2021-05-12 | Novocure Gmbh | Uso de campos electricos alternativos para aumentar la permeabilidad de la barrera hematoencefalica. |
| US11623085B2 (en) | 2018-08-29 | 2023-04-11 | Regents Of The University Of Minnesota | Devices and methods for treatment of tumors using electromagnetic signal |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| US11020585B2 (en) | 2018-09-07 | 2021-06-01 | Novocure Gmbh | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| HUE061361T2 (hu) | 2018-10-15 | 2023-06-28 | Novocure Gmbh | Az egész agyban nagy egyenletességû tumorkezelõ mezõk (TT-mezõk) generálása |
| CN112955208B (zh) | 2018-10-25 | 2024-11-22 | 诺沃库勒有限责任公司 | 向受试者的脊柱解剖结构递送交变电场(例如,ttfields)的方法 |
| US12186575B2 (en) | 2018-11-13 | 2025-01-07 | The Methodist Hospital | Method and apparatus for oncomagnetic treatment |
| HUE065574T2 (hu) | 2018-11-19 | 2024-06-28 | Novocure Gmbh | Tömbök daganatkezelõ mezõk (TTFIELD) rendelkezésre bocsátására szelektíven címezhetõ alelemekkel |
| JP7353363B2 (ja) | 2018-11-29 | 2023-09-29 | ノボキュア ゲーエムベーハー | TTFields(腫瘍治療電場)を提供するための柔軟性を高めたトランスデューサーアレイ |
| EP3968279B1 (en) | 2019-01-08 | 2025-01-01 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| WO2020174403A1 (en) | 2019-02-26 | 2020-09-03 | Moshe Giladi | Determining a frequency for ttfields treatment based on an electrical characteristic of targeted cancer cells |
| EP4491214B1 (en) | 2019-02-27 | 2026-01-21 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| PL3946322T3 (pl) | 2019-03-29 | 2024-02-26 | Novocure Gmbh | Sposoby przywracania wrażliwości na ttfields w komórkach nowotworowych opornych wobec ttfields, z inhibitorami ptger3 |
| CN111803792A (zh) * | 2019-04-12 | 2020-10-23 | 上海必修福企业管理有限公司 | 空间电场的发生装置 |
| WO2020212824A1 (en) | 2019-04-17 | 2020-10-22 | Yoram Wasserman | Uploading data from an isolated system without compromising isolation |
| CN114007535A (zh) | 2019-04-18 | 2022-02-01 | 盖乐世公司 | 用于治疗异常组织的装置、系统和方法 |
| CN113766949B (zh) * | 2019-04-22 | 2025-04-08 | 波士顿科学国际有限公司 | 用于施用电刺激以治疗癌症的系统 |
| JP7593942B2 (ja) | 2019-04-22 | 2024-12-03 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 癌治療のための電気刺激機器 |
| US12109412B2 (en) | 2019-04-22 | 2024-10-08 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| JP2022529374A (ja) | 2019-04-23 | 2022-06-21 | ボストン サイエンティフィック サイムド,インコーポレイテッド | がん治療のための電気刺激用電極 |
| WO2020219521A1 (en) * | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation with thermal treatment or thermal monitoring |
| CA3147592A1 (en) | 2019-07-16 | 2021-01-21 | Galary, Inc. | Treatment of the reproductive tract with pulsed electric fields |
| CN121314073A (zh) | 2019-07-31 | 2026-01-13 | 诺沃库勒有限责任公司 | 经由埋入颅骨植入物中的电极施加肿瘤治疗场(TTField) |
| CN114390914A (zh) | 2019-08-05 | 2022-04-22 | 诺沃库勒有限责任公司 | 通过抑制il11活性增加癌细胞对肿瘤治疗场(ttfield)的敏感性 |
| US11890467B2 (en) | 2019-08-30 | 2024-02-06 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the neck |
| US12458709B2 (en) * | 2019-12-11 | 2025-11-04 | Novocure Gmbh | Compositions and methods for imaging a cell |
| JP7687698B2 (ja) * | 2019-12-26 | 2025-06-03 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 癌細胞における異常な解糖的代謝を正常化する方法 |
| HUE061733T2 (hu) | 2019-12-31 | 2023-08-28 | Novocure Gmbh | Tömbök tumorkezelõ mezõk (TTFields) szállítására egyenként hozzáférhetõ elektródaelemekkel és hõmérsékletérzékelõkkel |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| US20230147250A1 (en) * | 2019-12-31 | 2023-05-11 | Novocure Gmbh | Methods, systems, and apparatuses for combined tumor treating fields and mental health therapy |
| KR20220122679A (ko) | 2019-12-31 | 2022-09-02 | 노보큐어 게엠베하 | 채널들의 스위칭 및 진폭 조정 중 스파이크들을 방지하는 고전압, 고효율 사인파 생성기 |
| US11883655B2 (en) | 2020-02-24 | 2024-01-30 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| US20210299440A1 (en) | 2020-03-30 | 2021-09-30 | Novocure Gmbh | Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases |
| KR102644003B1 (ko) * | 2020-04-01 | 2024-03-07 | 한국전자통신연구원 | 암 치료 장치 |
| CN115348844A (zh) | 2020-04-08 | 2022-11-15 | 盖能适治疗股份有限公司 | 脉冲电场波形操作和使用 |
| CN115916325A (zh) * | 2020-04-24 | 2023-04-04 | 诺沃库勒有限责任公司 | 使用交变电场增加血脑屏障的通透性 |
| CN115443171A (zh) * | 2020-05-08 | 2022-12-06 | 诺沃库勒有限责任公司 | 向多能干细胞施加交变电场的组合物和方法 |
| KR102464313B1 (ko) | 2020-05-18 | 2022-11-08 | 주식회사 필드큐어 | 전기장 암 치료 시스템을 위한 품질 보증 장치 및 방법 |
| WO2021257967A1 (en) | 2020-06-19 | 2021-12-23 | The Methodist Hospital Dba Houston Methodist Hospital | Method and apparatus for oncomagnetic treatment |
| US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
| EP4567054B1 (en) * | 2020-06-30 | 2025-12-17 | Novocure GmbH | Flexible transducer arrays with a polymer insulating layer for applying tumor treating fields (ttfields) |
| JP7886853B2 (ja) * | 2020-09-18 | 2026-07-08 | ノボキュア ゲーエムベーハー | コロナウイルスを処置するための方法及び組成物 |
| EP4223363B1 (en) | 2020-09-25 | 2024-04-24 | Novocure GmbH | Varying the metallization area on individual electrode elements in a tumor treating fields system to maximize current without overheating |
| JP7145280B2 (ja) * | 2020-10-13 | 2022-09-30 | Tvs Regza株式会社 | 送受信方法 |
| KR102519139B1 (ko) | 2020-11-25 | 2023-04-25 | 주식회사 필드큐어 | 회전하는 교류 전기장을 이용한 전기장 인가 장치 및 방법 |
| WO2022112945A1 (en) * | 2020-11-25 | 2022-06-02 | Novocure Gmbh | Increasing the efficacy of tumor treating fields (ttfields) by applying the ttfields at peak intensity less than half the time |
| WO2022130183A2 (en) | 2020-12-17 | 2022-06-23 | Novocure Gmbh | Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields) |
| CN116782980A (zh) | 2020-12-21 | 2023-09-19 | 诺沃库勒有限责任公司 | 复合电极的优化 |
| CN112553075A (zh) * | 2020-12-28 | 2021-03-26 | 湖南安泰康成生物科技有限公司 | 一种用敏感频率电场抑制肿瘤细胞快速生长的方法及装置 |
| CN117098577A (zh) * | 2020-12-30 | 2023-11-21 | 诺沃库勒有限责任公司 | 用于肿瘤治疗场的调幅 |
| WO2022147153A1 (en) * | 2020-12-30 | 2022-07-07 | Novocure Gmbh | Amplitude modulation for tumor treating fields |
| IT202100000119A1 (it) * | 2021-01-05 | 2022-07-05 | Telea Electronic Eng Srl | Dispositivo e farmaco antitumorale per il trattamento di cellule neoplastiche |
| US20220241603A1 (en) * | 2021-02-03 | 2022-08-04 | Novocure Gmbh | Varying Parameters of Tumor Treating Fields (TTFields) Treatment to Overcome Treatment Resistance |
| EP4043071A1 (en) * | 2021-02-12 | 2022-08-17 | Scientia Biotech S.L. | Non-invasive cancer treatment |
| JP7844490B2 (ja) | 2021-02-17 | 2026-04-13 | ノボキュア ゲーエムベーハー | 個別に調節可能な活性領域を有する電極素子のセットで腫瘍治療電場(TTFields)を送達するためのアレイ |
| JP2024509964A (ja) | 2021-03-12 | 2024-03-05 | ノボキュア ゲーエムベーハー | 交流電界を用いてマクロファージの表現型をスキューイングすることによる、疾患を処置する方法 |
| WO2022200964A1 (en) * | 2021-03-23 | 2022-09-29 | Novocure Gmbh | Transducer apparatuses for delivering tumor treating fields to a subject's body |
| CN117120139A (zh) | 2021-03-31 | 2023-11-24 | 诺沃库勒有限责任公司 | 使用肿瘤治疗场(ttfield)系统的电极的阻抗断层摄影 |
| WO2022215051A1 (en) | 2021-04-08 | 2022-10-13 | Novocure Gmbh | Methods of treating neurodegenerative disorders with alternating electric fields |
| TWI905187B (zh) * | 2021-05-11 | 2025-11-21 | 瑞士商諾萬可有限公司 | 用於治療子宮外孕的交變電場 |
| CN113373198A (zh) * | 2021-06-17 | 2021-09-10 | 上海睿钰生物科技有限公司 | 一种确定细胞的迁移能力的方法和系统 |
| CR20240027A (es) * | 2021-06-22 | 2024-05-28 | Lifebridge Innovations Pbc | Aparato y método para mejorar la terapia de campo eléctrico para reducir tumores sólidos |
| MX2023014225A (es) | 2021-06-30 | 2024-01-24 | Novocure Gmbh | Uso de condensadores para regular la corriente en matrices de transductores para aplicar campos de tratamiento de tumores (ttfields). |
| US20230001221A1 (en) * | 2021-06-30 | 2023-01-05 | Novocure Gmbh | Methods of Treating Cancer with Alternating Electric Fields, Checkpoint Inhibitors, and Combination Chemotherapy |
| EP4408516A1 (en) * | 2021-09-30 | 2024-08-07 | Novocure GmbH | Reducing electrosensation whilst treating a subject using alternating electric fields |
| IL312074A (en) | 2021-12-14 | 2024-06-01 | Novocure Gmbh | Moving a transducer array to reduce skin irritation |
| CN121371475B (zh) * | 2021-12-22 | 2026-07-17 | 江苏海莱新创医疗科技有限公司 | 胶质瘤治疗系统 |
| CN121422385B (zh) * | 2021-12-22 | 2026-07-17 | 江苏海莱新创医疗科技有限公司 | 肝癌治疗系统 |
| TW202333820A (zh) | 2021-12-29 | 2023-09-01 | 瑞士商諾沃庫勒有限責任公司 | 在使用交流電場治療受試者時藉由使用較大陰極和較小陽極來降低電知覺 |
| EP4456971A1 (en) | 2021-12-30 | 2024-11-06 | Novocure GmbH | Selecting values of parameters for treatment using tumor treating fields (ttfields) |
| IL314390A (en) * | 2022-03-30 | 2024-09-01 | Novocure Gmbh | Using interleaved cooling periods to increase the peak intensity of tumor treating fields |
| EP4464370B1 (en) | 2022-03-30 | 2026-04-29 | Novocure GmbH | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together |
| US20230310854A1 (en) * | 2022-03-31 | 2023-10-05 | Novocure Gmbh | Alternating electric field waveform for electrosensation reduction |
| WO2023193012A2 (en) | 2022-04-01 | 2023-10-05 | The Board Of Regents Of The University Of Texas System | Methods and apparatus for applying tumor treating fields combined with personalized ultra-fractionated stereotactic adaptive radiotherapy |
| TW202417078A (zh) | 2022-06-30 | 2024-05-01 | 瑞士商諾沃庫勒有限責任公司 | 用於施加腫瘤治療電場的包括多個熱連接但電隔離的石墨片之電極組裝件 |
| TW202430241A (zh) | 2022-09-30 | 2024-08-01 | 瑞士商諾沃庫勒有限責任公司 | 在使用交流電場治療受試者時藉由控制上升特性來降低電知覺 |
| US20260108733A1 (en) * | 2022-10-25 | 2026-04-23 | Fieldcure Co., Ltd. | System and method for electric field transmission |
| KR102853607B1 (ko) * | 2022-10-25 | 2025-09-03 | 주식회사 필드큐어 | 전기장 전달 시스템 및 방법 |
| US12649061B2 (en) | 2022-12-29 | 2026-06-09 | Novocure Gmbh | Reducing electrosensation during application of alternating electric fields by ensuring that successive increases in amplitude occur during opposite phases of an AC waveform |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| GB2631521A (en) * | 2023-07-05 | 2025-01-08 | Qv Bioelectronics Ltd | Electric field therapy |
| US12558538B2 (en) | 2023-09-29 | 2026-02-24 | Novocure Gmbh | Using staggered changes in amplitude and frequency to ameliorate electrosensation during treatment with alternating electric fields |
| US20260083819A1 (en) * | 2024-09-20 | 2026-03-26 | Novocure Gmbh | Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and interferon gamma |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5873849A (en) | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| US6326177B1 (en) * | 1999-08-04 | 2001-12-04 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Method and apparatus for intracellular electro-manipulation |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US7890183B2 (en) | 2000-02-17 | 2011-02-15 | Novocure Ltd. | Treating parasites with electric fields |
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US7016725B2 (en) * | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US8447395B2 (en) | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| EP2335776A1 (en) | 2000-02-17 | 2011-06-22 | Yoram Palti | Method and apparatus for destroying dividing cells |
| US6546290B1 (en) | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
| US6904322B2 (en) | 2002-02-15 | 2005-06-07 | Kalaco Scientific, Inc. | Transcranial electrostimulation apparatus and method |
| WO2005115535A2 (en) | 2004-04-23 | 2005-12-08 | Novocure Ltd. | Treating a tumor or the like with electric fields at different frequencies |
| DK1833552T3 (da) | 2004-12-07 | 2010-08-02 | Standen Ltd | Elektroder til anbringelse af et elektrisk felt in-vivo i en længere tidsperiode |
| CN102488967B (zh) | 2004-12-27 | 2016-03-30 | 诺沃库勒有限公司 | 利用电场从不同方向治疗肿瘤等 |
| US20060173493A1 (en) | 2005-01-28 | 2006-08-03 | Cyberonics, Inc. | Multi-phasic signal for stimulation by an implantable device |
| DK3804809T3 (da) * | 2005-10-03 | 2024-02-12 | Novocure Gmbh | Optimering af egenskaberne af et elektrisk felt for at øge feltets effekt på proliferende celler |
| US8019414B2 (en) * | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| DK2167194T3 (en) | 2007-03-06 | 2017-06-19 | Novocure Ltd | TREATMENT OF CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY |
| US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
| US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US20190117963A1 (en) | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US9833617B2 (en) * | 2014-07-25 | 2017-12-05 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| EP3478360B1 (en) | 2016-06-30 | 2024-04-10 | Novocure GmbH | Arrays for longitudinal delivery of ttfields to a body |
| CA2972699A1 (en) | 2016-07-10 | 2018-01-10 | Novocure Limited | Synchronizing tumor cells to the g2/m phase using ttfields combined with taxane or other anti-microtubule agents |
| CN116747438A (zh) | 2016-08-18 | 2023-09-15 | 诺沃库勒有限责任公司 | 用于递送肿瘤治疗电场的阵列中的温度测量 |
| EP3554631B1 (en) | 2016-12-13 | 2022-03-23 | Novocure GmbH | Treating patients with ttfields with the electrode positions optimized using deformable templates |
| EP3571503B1 (en) | 2017-01-19 | 2026-04-15 | Novocure GmbH | System for viewing cell cultures under a microscope whilst applying ttfields |
| CN112566665A (zh) | 2018-04-09 | 2021-03-26 | 莫舍·吉拉迪 | 用TTFields和Aurora激酶抑制剂治疗肿瘤 |
| US11650277B2 (en) | 2018-04-10 | 2023-05-16 | Novocure Gmbh | TTField treatment with optimization of electrode positions based on low frequency (<1MHZ) AC conductivity estimates derived from two MRI images having different repetition times |
| KR102870236B1 (ko) | 2018-07-03 | 2025-10-14 | 에드윈 창 | 세포막 투과성을 향상시키기 위한 교류 전기장 사용 |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| IL279253B2 (en) | 2018-07-18 | 2025-09-01 | Novocure Gmbh | Using power loss density and related measurements to quantify dose of tumor treatment fields |
| MX2020013519A (es) | 2018-08-23 | 2021-05-12 | Novocure Gmbh | Uso de campos electricos alternativos para aumentar la permeabilidad de la barrera hematoencefalica. |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| US11020585B2 (en) | 2018-09-07 | 2021-06-01 | Novocure Gmbh | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| US20200108031A1 (en) | 2018-10-05 | 2020-04-09 | Novocure Gmbh | Treating Tumors Using TTFields Combined with ABT-751 |
| CN113164525B (zh) | 2018-10-23 | 2025-03-14 | 利兰·斯坦福青年大学托管委员会 | 在基于干细胞的疗法中使用交变电场预防和治疗畸胎瘤形成 |
| CN112955208B (zh) | 2018-10-25 | 2024-11-22 | 诺沃库勒有限责任公司 | 向受试者的脊柱解剖结构递送交变电场(例如,ttfields)的方法 |
| US20200146586A1 (en) | 2018-11-14 | 2020-05-14 | Novocure Gmbh | Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images |
| HUE065574T2 (hu) | 2018-11-19 | 2024-06-28 | Novocure Gmbh | Tömbök daganatkezelõ mezõk (TTFIELD) rendelkezésre bocsátására szelektíven címezhetõ alelemekkel |
| JP7353363B2 (ja) | 2018-11-29 | 2023-09-29 | ノボキュア ゲーエムベーハー | TTFields(腫瘍治療電場)を提供するための柔軟性を高めたトランスデューサーアレイ |
| EP3968279B1 (en) | 2019-01-08 | 2025-01-01 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| EP3939568A1 (en) | 2019-02-22 | 2022-01-19 | Novocure GmbH | Treating gastric cancer using ttfields and drug in combination |
| WO2020174403A1 (en) | 2019-02-26 | 2020-09-03 | Moshe Giladi | Determining a frequency for ttfields treatment based on an electrical characteristic of targeted cancer cells |
| EP4491214B1 (en) | 2019-02-27 | 2026-01-21 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| PL3946322T3 (pl) | 2019-03-29 | 2024-02-26 | Novocure Gmbh | Sposoby przywracania wrażliwości na ttfields w komórkach nowotworowych opornych wobec ttfields, z inhibitorami ptger3 |
| WO2020212824A1 (en) | 2019-04-17 | 2020-10-22 | Yoram Wasserman | Uploading data from an isolated system without compromising isolation |
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